⚙ How is this computed? Methods: Data Formats
Analysis Complete

Analysis Results sys05tis07

Published legacy analysis modules for the selected page.

Species: SP239
Tissue: sys05tis07
Generated: 2026-08-07 23:48
Modules: 5
๐Ÿ“Š Tissue Level
๐Ÿ“ก
8,488
Cell Interactions
๐Ÿงฌ
841
TF-Target Pairs
๐Ÿ“Š
1,999
Significant DEGs
๐ŸŽฏ
180
GO Terms
๐Ÿ›ค๏ธ
160
KEGG Pathways
๐Ÿ”—
30
Co-exp Modules
โš—๏ธ
โ€”
Metab. Pathways
๐Ÿฅ
22
Disease Links
๐Ÿ’Š
โ€”
Drugs Matched
๐Ÿ“ก Cell Communication โœ“ ๐Ÿงฌ GRN Analysis โœ“ ๐Ÿ”— Co-expression โœ“ ๐Ÿ”€ Trajectory Not computed ๐Ÿ“Š DEG Analysis โœ“ ๐ŸŽฏ GO / KEGG Not computed ๐Ÿงช ToppGene Not computed ๐Ÿ”  Motif Not computed โš—๏ธ Metabolism Not computed ๐Ÿฅ Disease โœ“ ๐Ÿ’Š Drug Analysis Not computed ๐Ÿ“„ Full Report
๐Ÿ“ก

Cell-Cell CommunicationLigand-Receptor Interaction Analysis via CellChat / CellPhoneDB

๐Ÿ”ข
Total Interactions
8,488
Significant ligand-receptor pairs
๐Ÿ›ค๏ธ
Signaling Pathways
27
Unique pathways detected
๐Ÿ“ค
Top Sender
Fibroblasts
Most active signaling cell type
๐Ÿ“ฅ
Top Receiver
B cells
Most active receiving cell type
Communication Heatmap

Communication Heatmap

Overall interaction strength between cell types. Rows = sender, columns = receiver.

๐Ÿ” Full Size
Communication Network

Communication Network

Network visualization of top 50 cell-cell interactions. Node size = connectivity degree.

๐Ÿ” Full Size
Signaling Pathway Activity

Signaling Pathway Activity

Top signaling pathways ranked by total communication score.

๐Ÿ” Full Size

๐Ÿ“‹ Top Ligand-Receptor Interactions

๐Ÿ“ฅ All Interactions ๐Ÿ“ฅ Pathway Summary
source target ligand receptor pathway ligand_expr receptor_expr score
Enterocytes Enterocytes TGFB1 TGFBR1 TGFb 0.0076 0.1115 0.0008
Enterocytes Cycling B cells TGFB1 TGFBR1 TGFb 0.0076 0.2121 0.0016
Enterocytes Innate lymphoid cells TGFB1 TGFBR1 TGFb 0.0076 0.346 0.0026
Enterocytes Endothelial cells TGFB1 TGFBR1 TGFb 0.0076 0.1946 0.0015
Enterocytes Macrophages TGFB1 TGFBR1 TGFb 0.0076 0.248 0.0019
Enterocytes Fibroblasts TGFB1 TGFBR1 TGFb 0.0076 0.8891 0.0067
Enterocytes B cells TGFB1 TGFBR1 TGFb 0.0076 0.2849 0.0022
Enterocytes Smooth muscle cells TGFB1 TGFBR1 TGFb 0.0076 0.2324 0.0018
Enterocytes CD4+ T cells TGFB1 TGFBR1 TGFb 0.0076 0.2328 0.0018
Enterocytes Pericytes TGFB1 TGFBR1 TGFb 0.0076 0.3131 0.0024
Enterocytes Enteric glial cells TGFB1 TGFBR1 TGFb 0.0076 0.3066 0.0023
Enterocytes CD8+ T cells TGFB1 TGFBR1 TGFb 0.0076 0.2506 0.0019
Showing top 12 rows ยท Download full table above
๐Ÿงฌ

Gene Regulatory NetworkTranscription Factor Activity & TF-Target Inference (pySCENIC / DoRothEA)

๐ŸŽ›๏ธ
TFs Analyzed
90
Transcription factors profiled
๐Ÿ”—
TF-Target Pairs
841
Significant regulatory relationships

Top Regulatory TFs

EGR1 119 targets
FOS 73 targets
CEBPB 71 targets
JUN 66 targets
SOX9 62 targets
FOXA1 61 targets
HNF4A 46 targets
TCF7 43 targets
IRF1 39 targets
IRF4 38 targets
TF Activity Heatmap

TF Activity Heatmap

Z-score normalized TF expression across cell populations.

๐Ÿ” Full Size ๐Ÿ“ฅ TF Activity ๐Ÿ“ฅ TF-Target Pairs
Gene Regulatory Network

Gene Regulatory Network

Red nodes: TFs. Blue: targets. Green edge: activation. Red edge: repression.

๐Ÿ” Full Size ๐Ÿ“ฅ TF Activity ๐Ÿ“ฅ TF-Target Pairs
๐Ÿ”—

Gene Co-expression NetworkWGCNA-style Module Analysis (hdWGCNA)

๐Ÿ“ฆ
Modules Identified
30
Co-expression gene modules
๐Ÿงฌ
Genes Analyzed
2,000
Highly variable genes
Module Dendrogram

Module Dendrogram

Hierarchical clustering of co-expression modules based on topological overlap.

๐Ÿ” Full Size ๐Ÿ“ฅ Gene Modules ๐Ÿ“ฅ Eigengenes
Module-Cell Type Association

Module-Cell Type Association

Module eigengene activity across cell types.

๐Ÿ” Full Size ๐Ÿ“ฅ Gene Modules ๐Ÿ“ฅ Eigengenes
๐Ÿ“Š

Differential ExpressionCell Type Marker Genes (Wilcoxon / MAST)

๐Ÿ“ˆ
Significant DEGs
1,999
Genes passing adj. p < 0.05 & |log2FC| > 0.5
๐Ÿท๏ธ
Cell Types Compared
20
Cell populations analyzed
Volcano Plot

Volcano Plot

Log2 fold change vs significance. Red: up-regulated. Blue: down-regulated.

Marker Gene Heatmap

Marker Gene Heatmap

Z-score normalized expression of top marker genes per cell type.

๐Ÿ“‹ Top Marker Genes

๐Ÿ“ฅ Top Markers ๐Ÿ“ฅ All Significant DEGs ๐Ÿ“ฅ Full DEG Results
names scores logfoldchanges pvals pvals_adj pct_nz_group pct_nz_reference cell_type
CD74 104.3856 6.4042 0 0 0.9996 0.4716 B cells
HLA-DRA 102.2421 6.2033 0 0 0.9936 0.257 B cells
MS4A1 96.3049 5.7519 0 0 0.9324 0.1144 B cells
CD22 47.7126 5.6311 0 0 0.4597 0.0205 B cells
CXCR4 97.9332 5.4571 0 0 0.975 0.253 B cells
HLA-DOB 57.5581 5.377 0 0 0.5589 0.0358 B cells
HLA-DPB1 98.4272 5.3326 0 0 0.9854 0.2281 B cells
BANK1 79.496 5.2947 0 0 0.7813 0.1126 B cells
PLAAT5 55.4299 5.2045 0 0 0.5443 0.0441 B cells
BCL11A 73.6123 5.1039 0 0 0.7237 0.0793 B cells
ICOS 43.1714 5.8718 0 0 0.4812 0.0228 CD4+ T cells
CD4 48.8728 5.4336 0 0 0.5481 0.0302 CD4+ T cells
Showing top 12 rows
๐Ÿฅ

Disease AssociationDisease Gene Enrichment (scDRS / DisGeNET / OMIM / ToppGene)

๐Ÿ”ฌ
Diseases Tested
15
Disease categories analyzed
โœ…
Significant Associations
22
Cell type-disease links (adj. p < 0.05)

Top Associated Diseases

Systemic lupus erythematosus Alzheimer disease Rheumatoid arthritis Multiple sclerosis Rheumatoid arthritis
Disease Association Heatmap

Disease Association Heatmap

-Log10(P-value) of disease gene enrichment per cell type.

Top Disease Associations

Top Disease Associations

Dot size: overlap genes. Color: significance.

๐Ÿ“ฅ Disease Enrichment Data
๐Ÿ“„

Full Analysis ReportComprehensive Summary & Downloads

๐Ÿ“Š

Interactive HTML Report

Complete analysis report with all figures, key findings, and data summaries in a standalone HTML page.

๐Ÿ“„ Open Report
๐Ÿ“ฆ

Download All Results

Download all analysis results including CSV data, PNG figures, and JSON summaries as a compressed archive.

๐Ÿ“ฅ Download ZIP
๐Ÿ”—

Share Results

Use this permanent link to share these analysis results:

analysis.php?SP_ID=SP239&tisID=sys05tis07

๐Ÿ“ Available Result Files

Analysis File Type Action
Cell Communication cellchat_heatmap.png Figure (PNG) ๐Ÿ” View
Cell Communication cellchat_network.png Figure (PNG) ๐Ÿ” View
Cell Communication cellchat_pathway_dotplot.png Figure (PNG) ๐Ÿ” View
Cell Communication cellchat_interactions.csv Data (CSV) ๐Ÿ“ฅ Download
Cell Communication cellchat_pathway_summary.csv Data (CSV) ๐Ÿ“ฅ Download
GRN Analysis grn_tf_heatmap.png Figure (PNG) ๐Ÿ” View
GRN Analysis grn_network.png Figure (PNG) ๐Ÿ” View
GRN Analysis grn_tf_activity.csv Data (CSV) ๐Ÿ“ฅ Download
GRN Analysis grn_tf_targets.csv Data (CSV) ๐Ÿ“ฅ Download
Co-expression coexp_dendrogram.png Figure (PNG) ๐Ÿ” View
Co-expression coexp_module_heatmap.png Figure (PNG) ๐Ÿ” View
Co-expression coexp_modules.csv Data (CSV) ๐Ÿ“ฅ Download
Co-expression coexp_eigengenes.csv Data (CSV) ๐Ÿ“ฅ Download
DEG Analysis deg_volcano.png Figure (PNG) ๐Ÿ” View
DEG Analysis deg_marker_heatmap.png Figure (PNG) ๐Ÿ” View
DEG Analysis deg_top_markers.csv Data (CSV) ๐Ÿ“ฅ Download
DEG Analysis deg_significant.csv Data (CSV) ๐Ÿ“ฅ Download
DEG Analysis deg_all_results.csv Data (CSV) ๐Ÿ“ฅ Download
Disease disease_heatmap.png Figure (PNG) ๐Ÿ” View
Disease disease_dotplot.png Figure (PNG) ๐Ÿ” View
Disease disease_enrichment.csv Data (CSV) ๐Ÿ“ฅ Download
Report sys05tis07_analysis_report.html Report (HTML) ๐Ÿ“„ Open
Report sys05tis07_summary.json Summary (JSON) ๐Ÿ“ฅ Download