Total Interactions
1,483
Significant ligand-receptor pairs
Analysis Complete
Analysis Results sys09tis02
Published legacy analysis modules for the selected page.
๐ Tissue Level
Cell Communication
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GRN Analysis
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Co-expression
โ
Trajectory
Not computed
DEG Analysis
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GO / KEGG
Not computed
ToppGene
Not computed
Motif
Not computed
Metabolism
Not computed
Disease
โ
Drug Analysis
Not computed
Full Report
Cell-Cell CommunicationLigand-Receptor Interaction Analysis via CellChat / CellPhoneDB
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๐ค๏ธ
Signaling Pathways
26
Unique pathways detected
๐ค
Top Sender
Macrophages
Most active signaling cell type
๐ฅ
Top Receiver
DN T cells
Most active receiving cell type
Communication Heatmap
Overall interaction strength between cell types. Rows = sender, columns = receiver.
Communication Network
Network visualization of top 50 cell-cell interactions. Node size = connectivity degree.
Signaling Pathway Activity
Top signaling pathways ranked by total communication score.
๐ Top Ligand-Receptor Interactions
| source | target | ligand | receptor | pathway | ligand_expr | receptor_expr | score |
|---|---|---|---|---|---|---|---|
| Mesothelial cells | Mesothelial cells | TGFB1 | TGFBR1 | TGFb | 0.0037 | 0.0835 | 0.0003 |
| Mesothelial cells | Urothelial cells | TGFB1 | TGFBR1 | TGFb | 0.0037 | 0.1105 | 0.0004 |
| Mesothelial cells | Fibroblasts | TGFB1 | TGFBR1 | TGFb | 0.0037 | 0.1979 | 0.0007 |
| Mesothelial cells | Smooth muscle cells | TGFB1 | TGFBR1 | TGFb | 0.0037 | 0.2113 | 0.0008 |
| Mesothelial cells | Endothelial cells | TGFB1 | TGFBR1 | TGFb | 0.0037 | 0.0921 | 0.0003 |
| Mesothelial cells | Macrophages | TGFB1 | TGFBR1 | TGFb | 0.0037 | 0.0967 | 0.0004 |
| Mesothelial cells | Adipocytes | TGFB1 | TGFBR1 | TGFb | 0.0037 | 0.0777 | 0.0003 |
| Mesothelial cells | DN T cells | TGFB1 | TGFBR1 | TGFb | 0.0037 | 0.2995 | 0.0011 |
| Mesothelial cells | Cycling urothelial cells | TGFB1 | TGFBR1 | TGFb | 0.0037 | 0.2449 | 0.0009 |
| Urothelial cells | Mesothelial cells | TGFB1 | TGFBR1 | TGFb | 0.0141 | 0.0835 | 0.0012 |
| Urothelial cells | Urothelial cells | TGFB1 | TGFBR1 | TGFb | 0.0141 | 0.1105 | 0.0016 |
| Urothelial cells | Fibroblasts | TGFB1 | TGFBR1 | TGFb | 0.0141 | 0.1979 | 0.0028 |
Showing top 12 rows ยท Download full table above
Gene Regulatory NetworkTranscription Factor Activity & TF-Target Inference (pySCENIC / DoRothEA)
๐๏ธ
TFs Analyzed
90
Transcription factors profiled
๐
TF-Target Pairs
151
Significant regulatory relationships
Top Regulatory TFs
GATA3
48 targets
RUNX1
47 targets
FOXA1
22 targets
GATA2
16 targets
RUNX2
15 targets
LEF1
3 targets
TF Activity Heatmap
Z-score normalized TF expression across cell populations.
Gene Regulatory Network
Red nodes: TFs. Blue: targets. Green edge: activation. Red edge: repression.
Gene Co-expression NetworkWGCNA-style Module Analysis (hdWGCNA)
๐ฆ
Modules Identified
30
Co-expression gene modules
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Genes Analyzed
2,000
Highly variable genes
Module Dendrogram
Hierarchical clustering of co-expression modules based on topological overlap.
Module-Cell Type Association
Module eigengene activity across cell types.
Differential ExpressionCell Type Marker Genes (Wilcoxon / MAST)
๐
Significant DEGs
898
Genes passing adj. p < 0.05 & |log2FC| > 0.5
๐ท๏ธ
Cell Types Compared
9
Cell populations analyzed
Volcano Plot
Log2 fold change vs significance. Red: up-regulated. Blue: down-regulated.
Marker Gene Heatmap
Z-score normalized expression of top marker genes per cell type.
๐ Top Marker Genes
| names | scores | logfoldchanges | pvals | pvals_adj | pct_nz_group | pct_nz_reference | cell_type |
|---|---|---|---|---|---|---|---|
| ADTRP | 12.0812 | 9.416 | 0 | 0 | 0.5649 | 0.0023 | Adipocytes |
| GYS2 | 14.1388 | 9.009 | 0 | 0 | 0.6623 | 0.0042 | Adipocytes |
| PLIN1 | 11.505 | 8.7151 | 0 | 0 | 0.539 | 0.0033 | Adipocytes |
| TSHR | 16.8872 | 8.6447 | 0 | 0 | 0.7922 | 0.0145 | Adipocytes |
| LGALS12 | 8.8751 | 8.6331 | 0 | 0 | 0.4156 | 0.0023 | Adipocytes |
| ADIPOQ | 8.4539 | 8.3892 | 0 | 0 | 0.3961 | 0.0022 | Adipocytes |
| KLB | 10.662 | 8.3489 | 0 | 0 | 0.5 | 0.0039 | Adipocytes |
| GRIK3 | 7.1874 | 7.6695 | 0 | 0 | 0.3377 | 0.0029 | Adipocytes |
| FABP4 | 12.926 | 7.6019 | 0 | 0 | 0.6104 | 0.0095 | Adipocytes |
| RASGEF1C | 8.12 | 7.1296 | 0 | 0 | 0.3831 | 0.0054 | Adipocytes |
| CENPE | 14.6595 | 9.6646 | 0 | 0 | 0.8224 | 0.0035 | Cycling urothelial cells |
| TOP2A | 14.1466 | 9.5207 | 0 | 0 | 0.7944 | 0.0057 | Cycling urothelial cells |
Showing top 12 rows
Disease AssociationDisease Gene Enrichment (scDRS / DisGeNET / OMIM / ToppGene)
๐ฌ
Diseases Tested
15
Disease categories analyzed
โ
Significant Associations
9
Cell type-disease links (adj. p < 0.05)
Top Associated Diseases
Disease Association Heatmap
-Log10(P-value) of disease gene enrichment per cell type.
Top Disease Associations
Dot size: overlap genes. Color: significance.
Full Analysis ReportComprehensive Summary & Downloads
Interactive HTML Report
Complete analysis report with all figures, key findings, and data summaries in a standalone HTML page.
๐ Open ReportDownload All Results
Download all analysis results including CSV data, PNG figures, and JSON summaries as a compressed archive.
๐ฅ Download ZIPShare Results
Use this permanent link to share these analysis results:
analysis.php?SP_ID=SP239&tisID=sys09tis02
๐ Available Result Files
| Analysis | File | Type | Action |
|---|---|---|---|
| Cell Communication | cellchat_heatmap.png | Figure (PNG) | ๐ View |
| Cell Communication | cellchat_network.png | Figure (PNG) | ๐ View |
| Cell Communication | cellchat_pathway_dotplot.png | Figure (PNG) | ๐ View |
| Cell Communication | cellchat_interactions.csv | Data (CSV) | ๐ฅ Download |
| Cell Communication | cellchat_pathway_summary.csv | Data (CSV) | ๐ฅ Download |
| GRN Analysis | grn_tf_heatmap.png | Figure (PNG) | ๐ View |
| GRN Analysis | grn_network.png | Figure (PNG) | ๐ View |
| GRN Analysis | grn_tf_activity.csv | Data (CSV) | ๐ฅ Download |
| GRN Analysis | grn_tf_targets.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_dendrogram.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_module_heatmap.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_modules.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_eigengenes.csv | Data (CSV) | ๐ฅ Download |
| DEG Analysis | deg_volcano.png | Figure (PNG) | ๐ View |
| DEG Analysis | deg_marker_heatmap.png | Figure (PNG) | ๐ View |
| DEG Analysis | deg_top_markers.csv | Data (CSV) | ๐ฅ Download |
| DEG Analysis | deg_significant.csv | Data (CSV) | ๐ฅ Download |
| DEG Analysis | deg_all_results.csv | Data (CSV) | ๐ฅ Download |
| Disease | disease_heatmap.png | Figure (PNG) | ๐ View |
| Disease | disease_dotplot.png | Figure (PNG) | ๐ View |
| Disease | disease_enrichment.csv | Data (CSV) | ๐ฅ Download |
| Report | sys09tis02_analysis_report.html | Report (HTML) | ๐ Open |
| Report | sys09tis02_summary.json | Summary (JSON) | ๐ฅ Download |