TFs Analyzed
67
Transcription factors profiled
Exploratory Modules Available
Analysis Results SP389
Published legacy analysis modules for the selected page.
๐ Species Level
Validated exploratory / stratified sample.
Artifact and provenance checks passed for the linked advanced-module package.
These tabs use a deterministic tissue x cell-type stratified sample
(n=1,674,
seed=20260808) and are descriptive cell-level analyses,
not donor-level inference. Cell communication, species-wide trajectory, and age association remain not computed.
Cell Communication
Not computed
TF Associations
Exploratory
Co-expression
Exploratory
Trajectory
Not computed
Marker Ranking
Exploratory
GO / KEGG
Not computed
ToppGene
Not computed
Motif
Not computed
Metabolism
Exploratory
Disease
Exploratory
Drug Analysis
Exploratory
Full Report
Exploratory TF-Target AssociationsPearson associations in the stratified sample; not causal regulatory inference
๐๏ธ
๐
TF-Target Pairs
214
Thresholded Pearson associations
Top TF Association Counts
EGR1
10 associations
EOMES
8 associations
IRF1
21 associations
IRF4
15 associations
LEF1
18 associations
NFKB1
7 associations
OTX2
14 associations
SOX2
27 associations
SOX9
10 associations
SP1
9 associations
TF Activity Heatmap
Z-score normalized TF expression across cell populations.
Exploratory TF-Target Association Network
Pearson TF-target associations in the stratified sample; not a causal regulatory network.
Gene Co-expression NetworkExpression-correlation modules in the stratified sample; descriptive only
๐ฆ
Modules Identified
30
Co-expression gene modules
๐งฌ
Genes Analyzed
2,000
Highly variable genes
Module Dendrogram
Hierarchical clustering of expression correlations in the stratified sample.
Module-Cell Type Association
Module eigengene activity across cell types.
Descriptive Marker RankingCell-type marker ranking in sampled cells; not donor-level differential inference
๐
Ranked Marker Rows
859
Cell-level descriptive thresholds; no independent donor replicates
๐ท๏ธ
Cell Types Compared
9
Cell populations analyzed
Marker Ranking Volcano Plot
Cell-level descriptive marker ranking; not donor-level differential inference.
Marker Gene Heatmap
Z-score normalized expression of top marker genes per cell type.
๐ Top Marker Genes
| names | scores | logfoldchanges | pvals | pvals_adj | pct_nz_group | pct_nz_reference | cell_type |
|---|---|---|---|---|---|---|---|
| MLC1 | 7.849 | 6.9018 | 0 | 0 | 0.2933 | 0.0058 | Astrocytes |
| SLC1A2 | 22.6388 | 6.341 | 0 | 0 | 0.8667 | 0.1572 | Astrocytes |
| SYTL1 | 7.1087 | 6.2524 | 0 | 0 | 0.2667 | 0.0051 | Astrocytes |
| ADGRD2 | 5.8272 | 5.8562 | 0 | 0 | 0.22 | 0.0058 | Astrocytes |
| PAX3 | 9.556 | 5.8327 | 0 | 0 | 0.3633 | 0.0124 | Astrocytes |
| FGFBP2 | 7.4255 | 5.505 | 0 | 0 | 0.2833 | 0.0109 | Astrocytes |
| CDO1 | 5.3902 | 5.1366 | 0 | 0 | 0.2067 | 0.0087 | Astrocytes |
| RHBG | 6.6976 | 4.9687 | 0 | 0 | 0.26 | 0.0153 | Astrocytes |
| HES5 | 7.7848 | 4.8981 | 0 | 0 | 0.3033 | 0.0189 | Astrocytes |
| GPR37L1 | 6.3136 | 4.6911 | 0 | 0 | 0.2467 | 0.016 | Astrocytes |
| SLC26A5 | 8.3448 | 5.7308 | 0 | 0 | 0.7091 | 0.0642 | Choroid plexus |
| EYA2 | 7.1888 | 5.7138 | 0 | 0 | 0.6 | 0.029 | Choroid plexus |
Showing top 12 rows
Metabolism AnalysisCurated metabolic gene-set expression scores; descriptive only
๐งช
Pathways Scored
12
Metabolic pathway gene sets tested
โ
Pathways Detected
12
Pathways with genes expressed in data
๐ท๏ธ
Cell Types Analyzed
9
Cell populations scored
Top Metabolic Pathways
Metabolic Pathway Heatmap
Curated metabolic gene-set expression scores across sampled cell types.
Top Metabolic Activities
Top pathway-cell type combinations ranked by activity score. Dot size: genes detected.
Disease AssociationCurated disease-gene set overlap; descriptive only
๐ฌ
Diseases Tested
15
Disease categories analyzed
โ
Significant Associations
9
Cell type-disease links (adj. p < 0.05)
Top Associated Diseases
Disease Association Heatmap
Curated disease-gene set overlap across sampled cell types; descriptive only.
Top Disease Associations
Dot size: overlap genes. Color: significance.
Drug Target AnalysisCurated drug-target expression matching; descriptive only
๐
Drugs Screened
18
Drug compounds evaluated
๐ฏ
Drugs with Targets
14
Drugs with target genes detected in data
๐ท๏ธ
Cell Types Analyzed
9
Cell populations scored
Top Associated Drugs
Drug Target Expression Heatmap
Curated drug-target expression scores across sampled cell types; descriptive only.
Top DrugโCell Type Associations
Dot size: % cells expressing targets. Color: number of targets detected.
๐ DrugโCell Type Scores
| drug | cell_type | category | indication | targets_detected | targets_total | mean_target_expr | pct_cells_expressing | deg_overlap | target_genes |
|---|---|---|---|---|---|---|---|---|---|
| Imatinib | Microglia | Kinase inhibitor | CML / GIST | 5 | 5 | 0.5013 | 60.4167 | 1 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Astrocytes | Kinase inhibitor | CML / GIST | 5 | 5 | 0.1831 | 31.3333 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Endothelial cells | Kinase inhibitor | CML / GIST | 5 | 5 | 0.2276 | 34.2857 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Inhibitory neurons | Kinase inhibitor | CML / GIST | 5 | 5 | 0.0594 | 13.3333 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Oligodendrocytes | Kinase inhibitor | CML / GIST | 5 | 5 | 0.0511 | 9.3897 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Excitatory neurons | Kinase inhibitor | CML / GIST | 5 | 5 | 0.0459 | 10.3333 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Choroid plexus | Kinase inhibitor | CML / GIST | 5 | 5 | 0.1989 | 30.9091 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Oligodendrocyte progenitor cells | Kinase inhibitor | CML / GIST | 5 | 5 | 0.0654 | 13 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Fibroblasts | Kinase inhibitor | CML / GIST | 5 | 5 | 0.3421 | 52.0833 | 1 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Trastuzumab | Microglia | mAb | Breast cancer | 1 | 1 | 0.0224 | 1.0417 | 0 | ERBB2 |
| Trastuzumab | Astrocytes | mAb | Breast cancer | 1 | 1 | 0.244 | 9.6667 | 0 | ERBB2 |
| Trastuzumab | Endothelial cells | mAb | Breast cancer | 1 | 1 | 0.0649 | 2.8571 | 0 | ERBB2 |
Showing top 12 rows ยท Download full table above
Exploratory Analysis FilesValidated module artifacts and individual downloads
Exploratory Result Files
Use the validated per-module links below. The general Atlas ZIP endpoint is not presented as containing this linked exploratory package.
Share Results
Use this permanent link to share these analysis results:
analysis.php?SP_ID=SP389
๐ Available Result Files
| Analysis | File | Type | Action |
|---|---|---|---|
| TF Associations | grn_tf_heatmap.png | Figure (PNG) | ๐ View |
| TF Associations | grn_network.png | Figure (PNG) | ๐ View |
| TF Associations | grn_tf_activity.csv | Data (CSV) | ๐ฅ Download |
| TF Associations | grn_tf_targets.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_dendrogram.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_module_heatmap.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_modules.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_eigengenes.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_volcano.png | Figure (PNG) | ๐ View |
| Marker Ranking | deg_marker_heatmap.png | Figure (PNG) | ๐ View |
| Marker Ranking | deg_top_markers.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_significant.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_all_results.csv | Data (CSV) | ๐ฅ Download |
| Metabolism | metabolism_heatmap.png | Figure (PNG) | ๐ View |
| Metabolism | metabolism_dotplot.png | Figure (PNG) | ๐ View |
| Metabolism | metabolism_scores.csv | Data (CSV) | ๐ฅ Download |
| Disease | disease_heatmap.png | Figure (PNG) | ๐ View |
| Disease | disease_dotplot.png | Figure (PNG) | ๐ View |
| Disease | disease_enrichment.csv | Data (CSV) | ๐ฅ Download |
| Drug Analysis | drug_heatmap.png | Figure (PNG) | ๐ View |
| Drug Analysis | drug_dotplot.png | Figure (PNG) | ๐ View |
| Drug Analysis | drug_scores.csv | Data (CSV) | ๐ฅ Download |
| Report | SP389_summary.json | Summary (JSON) | ๐ฅ Download |