TFs Analyzed
68
Transcription factors profiled
Exploratory Modules Available
Analysis Results SP438
Published legacy analysis modules for the selected page.
๐ Species Level
Validated exploratory / stratified sample.
Artifact and provenance checks passed for the linked advanced-module package.
These tabs use a deterministic tissue x cell-type stratified sample
(n=1,701,
seed=20260808) and are descriptive cell-level analyses,
not donor-level inference. Cell communication, species-wide trajectory, and age association remain not computed.
Cell Communication
Not computed
TF Associations
Exploratory
Co-expression
Exploratory
Trajectory
Not computed
Marker Ranking
Exploratory
GO / KEGG
Not computed
ToppGene
Not computed
Motif
Not computed
Metabolism
Exploratory
Disease
Exploratory
Drug Analysis
Exploratory
Full Report
Exploratory TF-Target AssociationsPearson associations in the stratified sample; not causal regulatory inference
๐๏ธ
๐
TF-Target Pairs
296
Thresholded Pearson associations
Top TF Association Counts
AHR
14 associations
CEBPA
36 associations
CEBPB
56 associations
FOS
9 associations
LEF1
11 associations
NFKB1
23 associations
RUNX1
15 associations
SOX2
18 associations
SOX9
24 associations
TCF7
13 associations
TF Activity Heatmap
Z-score normalized TF expression across cell populations.
Exploratory TF-Target Association Network
Pearson TF-target associations in the stratified sample; not a causal regulatory network.
Gene Co-expression NetworkExpression-correlation modules in the stratified sample; descriptive only
๐ฆ
Modules Identified
30
Co-expression gene modules
๐งฌ
Genes Analyzed
2,000
Highly variable genes
Module Dendrogram
Hierarchical clustering of expression correlations in the stratified sample.
Module-Cell Type Association
Module eigengene activity across cell types.
Descriptive Marker RankingCell-type marker ranking in sampled cells; not donor-level differential inference
๐
Ranked Marker Rows
600
Cell-level descriptive thresholds; no independent donor replicates
๐ท๏ธ
Cell Types Compared
6
Cell populations analyzed
Marker Ranking Volcano Plot
Cell-level descriptive marker ranking; not donor-level differential inference.
Marker Gene Heatmap
Z-score normalized expression of top marker genes per cell type.
๐ Top Marker Genes
| names | scores | logfoldchanges | pvals | pvals_adj | pct_nz_group | pct_nz_reference | cell_type |
|---|---|---|---|---|---|---|---|
| MLC1 | 8.03 | 8.2287 | 0 | 0 | 0.2967 | 0.0021 | Astrocytes |
| ATP1A1 | 15.8966 | 7.1859 | 0 | 0 | 0.5967 | 0.02 | Astrocytes |
| MMD2 | 8.7679 | 7.0373 | 0 | 0 | 0.3267 | 0.0057 | Astrocytes |
| GFAP | 8.6447 | 6.6862 | 0 | 0 | 0.3233 | 0.0064 | Astrocytes |
| WNT7A | 9.5127 | 6.5719 | 0 | 0 | 0.3567 | 0.0093 | Astrocytes |
| ITPRID2 | 12.012 | 6.5348 | 0 | 0 | 0.4533 | 0.0128 | Astrocytes |
| FGFR2 | 10.9657 | 6.3864 | 0 | 0 | 0.4133 | 0.0121 | Astrocytes |
| ATP1B4 | 11.6498 | 6.316 | 0 | 0 | 0.44 | 0.0171 | Astrocytes |
| PDGFRB | 5.8672 | 6.2832 | 0 | 0 | 0.22 | 0.005 | Astrocytes |
| PLCB1 | 14.2062 | 6.2711 | 0 | 0 | 0.54 | 0.0286 | Astrocytes |
| RBFOX3 | 15.5754 | 3.4736 | 0 | 0 | 0.88 | 0.4347 | Excitatory neurons |
| NRXN3 | 13.7021 | 2.9553 | 0 | 0 | 0.82 | 0.4304 | Excitatory neurons |
Showing top 12 rows
Metabolism AnalysisCurated metabolic gene-set expression scores; descriptive only
๐งช
Pathways Scored
12
Metabolic pathway gene sets tested
โ
Pathways Detected
12
Pathways with genes expressed in data
๐ท๏ธ
Cell Types Analyzed
6
Cell populations scored
Top Metabolic Pathways
Metabolic Pathway Heatmap
Curated metabolic gene-set expression scores across sampled cell types.
Top Metabolic Activities
Top pathway-cell type combinations ranked by activity score. Dot size: genes detected.
Disease AssociationCurated disease-gene set overlap; descriptive only
๐ฌ
Diseases Tested
15
Disease categories analyzed
โ
Significant Associations
4
Cell type-disease links (adj. p < 0.05)
Top Associated Diseases
Disease Association Heatmap
Curated disease-gene set overlap across sampled cell types; descriptive only.
Top Disease Associations
Dot size: overlap genes. Color: significance.
Drug Target AnalysisCurated drug-target expression matching; descriptive only
๐
Drugs Screened
18
Drug compounds evaluated
๐ฏ
Drugs with Targets
14
Drugs with target genes detected in data
๐ท๏ธ
Cell Types Analyzed
6
Cell populations scored
Top Associated Drugs
Drug Target Expression Heatmap
Curated drug-target expression scores across sampled cell types; descriptive only.
Top DrugโCell Type Associations
Dot size: % cells expressing targets. Color: number of targets detected.
๐ DrugโCell Type Scores
| drug | cell_type | category | indication | targets_detected | targets_total | mean_target_expr | pct_cells_expressing | deg_overlap | target_genes |
|---|---|---|---|---|---|---|---|---|---|
| Imatinib | Pericytes | Kinase inhibitor | CML / GIST | 5 | 5 | 0.0136 | 2 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Astrocytes | Kinase inhibitor | CML / GIST | 5 | 5 | 0.2403 | 33.3333 | 1 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Inhibitory neurons | Kinase inhibitor | CML / GIST | 5 | 5 | 0.0515 | 9 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Oligodendrocytes | Kinase inhibitor | CML / GIST | 5 | 5 | 0.0752 | 12.3333 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Excitatory neurons | Kinase inhibitor | CML / GIST | 5 | 5 | 0.0115 | 2 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Microglia | Kinase inhibitor | CML / GIST | 5 | 5 | 0.3004 | 37.3134 | 1 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Trastuzumab | Pericytes | mAb | Breast cancer | 1 | 1 | 0.013 | 0.3333 | 0 | ERBB2 |
| Trastuzumab | Astrocytes | mAb | Breast cancer | 1 | 1 | 0.216 | 7.3333 | 0 | ERBB2 |
| Trastuzumab | Inhibitory neurons | mAb | Breast cancer | 1 | 1 | 0.0507 | 2 | 0 | ERBB2 |
| Trastuzumab | Oligodendrocytes | mAb | Breast cancer | 1 | 1 | 0.0249 | 0.6667 | 0 | ERBB2 |
| Trastuzumab | Excitatory neurons | mAb | Breast cancer | 1 | 1 | 0.0162 | 0.6667 | 0 | ERBB2 |
| Trastuzumab | Microglia | mAb | Breast cancer | 1 | 1 | 0 | 0 | 0 | ERBB2 |
Showing top 12 rows ยท Download full table above
Exploratory Analysis FilesValidated module artifacts and individual downloads
Exploratory Result Files
Use the validated per-module links below. The general Atlas ZIP endpoint is not presented as containing this linked exploratory package.
Share Results
Use this permanent link to share these analysis results:
analysis.php?SP_ID=SP438
๐ Available Result Files
| Analysis | File | Type | Action |
|---|---|---|---|
| TF Associations | grn_tf_heatmap.png | Figure (PNG) | ๐ View |
| TF Associations | grn_network.png | Figure (PNG) | ๐ View |
| TF Associations | grn_tf_activity.csv | Data (CSV) | ๐ฅ Download |
| TF Associations | grn_tf_targets.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_dendrogram.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_module_heatmap.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_modules.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_eigengenes.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_volcano.png | Figure (PNG) | ๐ View |
| Marker Ranking | deg_marker_heatmap.png | Figure (PNG) | ๐ View |
| Marker Ranking | deg_top_markers.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_significant.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_all_results.csv | Data (CSV) | ๐ฅ Download |
| Metabolism | metabolism_heatmap.png | Figure (PNG) | ๐ View |
| Metabolism | metabolism_dotplot.png | Figure (PNG) | ๐ View |
| Metabolism | metabolism_scores.csv | Data (CSV) | ๐ฅ Download |
| Disease | disease_heatmap.png | Figure (PNG) | ๐ View |
| Disease | disease_dotplot.png | Figure (PNG) | ๐ View |
| Disease | disease_enrichment.csv | Data (CSV) | ๐ฅ Download |
| Drug Analysis | drug_heatmap.png | Figure (PNG) | ๐ View |
| Drug Analysis | drug_dotplot.png | Figure (PNG) | ๐ View |
| Drug Analysis | drug_scores.csv | Data (CSV) | ๐ฅ Download |
| Report | SP438_summary.json | Summary (JSON) | ๐ฅ Download |