TFs Analyzed
72
Transcription factors profiled
Exploratory Modules Available
Analysis Results SP454
Published legacy analysis modules for the selected page.
๐ Species Level
Validated exploratory / stratified sample.
Artifact and provenance checks passed for the linked advanced-module package.
These tabs use a deterministic tissue x cell-type stratified sample
(n=2,093,
seed=20260808) and are descriptive cell-level analyses,
not donor-level inference. Cell communication, species-wide trajectory, and age association remain not computed.
Cell Communication
Not computed
TF Associations
Exploratory
Co-expression
Exploratory
Trajectory
Not computed
Marker Ranking
Exploratory
GO / KEGG
Not computed
ToppGene
Not computed
Motif
Not computed
Metabolism
Exploratory
Disease
Exploratory
Drug Analysis
Exploratory
Full Report
Exploratory TF-Target AssociationsPearson associations in the stratified sample; not causal regulatory inference
๐๏ธ
๐
TF-Target Pairs
506
Thresholded Pearson associations
Top TF Association Counts
CEBPA
50 associations
CEBPB
61 associations
GATA3
23 associations
IRF1
30 associations
LEF1
31 associations
NFKB1
47 associations
NR3C1
32 associations
SOX9
21 associations
STAT3
43 associations
TP53
42 associations
TF Activity Heatmap
Z-score normalized TF expression across cell populations.
Exploratory TF-Target Association Network
Pearson TF-target associations in the stratified sample; not a causal regulatory network.
Gene Co-expression NetworkExpression-correlation modules in the stratified sample; descriptive only
๐ฆ
Modules Identified
30
Co-expression gene modules
๐งฌ
Genes Analyzed
2,000
Highly variable genes
Module Dendrogram
Hierarchical clustering of expression correlations in the stratified sample.
Module-Cell Type Association
Module eigengene activity across cell types.
Descriptive Marker RankingCell-type marker ranking in sampled cells; not donor-level differential inference
๐
Ranked Marker Rows
800
Cell-level descriptive thresholds; no independent donor replicates
๐ท๏ธ
Cell Types Compared
8
Cell populations analyzed
Marker Ranking Volcano Plot
Cell-level descriptive marker ranking; not donor-level differential inference.
Marker Gene Heatmap
Z-score normalized expression of top marker genes per cell type.
๐ Top Marker Genes
| names | scores | logfoldchanges | pvals | pvals_adj | pct_nz_group | pct_nz_reference | cell_type |
|---|---|---|---|---|---|---|---|
| SLC1A2 | 23.3938 | 5.1926 | 0 | 0 | 0.9467 | 0.3001 | Astrocytes |
| HES5 | 8.2927 | 4.5253 | 0 | 0 | 0.32 | 0.0229 | Astrocytes |
| NR2E1 | 8.8743 | 4.0787 | 0 | 0 | 0.3533 | 0.034 | Astrocytes |
| KCNN2 | 14.6707 | 3.6538 | 0 | 0 | 0.6367 | 0.1389 | Astrocytes |
| ACSBG1 | 11.4858 | 3.6185 | 0 | 0 | 0.4833 | 0.0703 | Astrocytes |
| KCNJ10 | 14.7125 | 3.618 | 0 | 0 | 0.6533 | 0.1617 | Astrocytes |
| PTN | 12.6555 | 3.4907 | 0 | 0 | 0.5533 | 0.0993 | Astrocytes |
| NOTCH3 | 10.0638 | 3.4258 | 0 | 0 | 0.4267 | 0.0625 | Astrocytes |
| CHL1 | 15.205 | 3.3615 | 0 | 0 | 0.7067 | 0.2119 | Astrocytes |
| FNDC4 | 12.6577 | 3.2885 | 0 | 0 | 0.5667 | 0.1327 | Astrocytes |
| RASIP1 | 5.8587 | 30.7689 | 0 | 0 | 0.3626 | 0 | Endothelial cells |
| KDR | 5.5036 | 30.5634 | 0 | 0 | 0.3407 | 0 | Endothelial cells |
Showing top 12 rows
Metabolism AnalysisCurated metabolic gene-set expression scores; descriptive only
๐งช
Pathways Scored
12
Metabolic pathway gene sets tested
โ
Pathways Detected
12
Pathways with genes expressed in data
๐ท๏ธ
Cell Types Analyzed
8
Cell populations scored
Top Metabolic Pathways
Metabolic Pathway Heatmap
Curated metabolic gene-set expression scores across sampled cell types.
Top Metabolic Activities
Top pathway-cell type combinations ranked by activity score. Dot size: genes detected.
Disease AssociationCurated disease-gene set overlap; descriptive only
๐ฌ
Diseases Tested
15
Disease categories analyzed
โ
Significant Associations
4
Cell type-disease links (adj. p < 0.05)
Top Associated Diseases
Disease Association Heatmap
Curated disease-gene set overlap across sampled cell types; descriptive only.
Top Disease Associations
Dot size: overlap genes. Color: significance.
Drug Target AnalysisCurated drug-target expression matching; descriptive only
๐
Drugs Screened
18
Drug compounds evaluated
๐ฏ
Drugs with Targets
13
Drugs with target genes detected in data
๐ท๏ธ
Cell Types Analyzed
8
Cell populations scored
Top Associated Drugs
Drug Target Expression Heatmap
Curated drug-target expression scores across sampled cell types; descriptive only.
Top DrugโCell Type Associations
Dot size: % cells expressing targets. Color: number of targets detected.
๐ DrugโCell Type Scores
| drug | cell_type | category | indication | targets_detected | targets_total | mean_target_expr | pct_cells_expressing | deg_overlap | target_genes |
|---|---|---|---|---|---|---|---|---|---|
| Imatinib | Oligodendrocytes | Kinase inhibitor | CML / GIST | 5 | 5 | 0.0835 | 15.6667 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Inhibitory neurons | Kinase inhibitor | CML / GIST | 5 | 5 | 0.0711 | 17 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Astrocytes | Kinase inhibitor | CML / GIST | 5 | 5 | 0.2808 | 50.3333 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Endothelial cells | Kinase inhibitor | CML / GIST | 5 | 5 | 0.1485 | 24.1758 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Excitatory neurons | Kinase inhibitor | CML / GIST | 5 | 5 | 0.0515 | 14.3333 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Ependymal cells | Kinase inhibitor | CML / GIST | 5 | 5 | 0.1924 | 38.0952 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Microglia | Kinase inhibitor | CML / GIST | 5 | 5 | 0.7115 | 87.3333 | 1 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Fibroblasts | Kinase inhibitor | CML / GIST | 5 | 5 | 0.3296 | 57.2115 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Trastuzumab | Oligodendrocytes | mAb | Breast cancer | 1 | 1 | 0.0917 | 3.6667 | 0 | ERBB2 |
| Trastuzumab | Inhibitory neurons | mAb | Breast cancer | 1 | 1 | 0.0483 | 2.6667 | 0 | ERBB2 |
| Trastuzumab | Astrocytes | mAb | Breast cancer | 1 | 1 | 0.3093 | 14.3333 | 0 | ERBB2 |
| Trastuzumab | Endothelial cells | mAb | Breast cancer | 1 | 1 | 0.1613 | 5.4945 | 0 | ERBB2 |
Showing top 12 rows ยท Download full table above
Exploratory Analysis FilesValidated module artifacts and individual downloads
Exploratory Result Files
Use the validated per-module links below. The general Atlas ZIP endpoint is not presented as containing this linked exploratory package.
Share Results
Use this permanent link to share these analysis results:
analysis.php?SP_ID=SP454
๐ Available Result Files
| Analysis | File | Type | Action |
|---|---|---|---|
| TF Associations | grn_tf_heatmap.png | Figure (PNG) | ๐ View |
| TF Associations | grn_network.png | Figure (PNG) | ๐ View |
| TF Associations | grn_tf_activity.csv | Data (CSV) | ๐ฅ Download |
| TF Associations | grn_tf_targets.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_dendrogram.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_module_heatmap.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_modules.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_eigengenes.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_volcano.png | Figure (PNG) | ๐ View |
| Marker Ranking | deg_marker_heatmap.png | Figure (PNG) | ๐ View |
| Marker Ranking | deg_top_markers.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_significant.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_all_results.csv | Data (CSV) | ๐ฅ Download |
| Metabolism | metabolism_heatmap.png | Figure (PNG) | ๐ View |
| Metabolism | metabolism_dotplot.png | Figure (PNG) | ๐ View |
| Metabolism | metabolism_scores.csv | Data (CSV) | ๐ฅ Download |
| Disease | disease_heatmap.png | Figure (PNG) | ๐ View |
| Disease | disease_dotplot.png | Figure (PNG) | ๐ View |
| Disease | disease_enrichment.csv | Data (CSV) | ๐ฅ Download |
| Drug Analysis | drug_heatmap.png | Figure (PNG) | ๐ View |
| Drug Analysis | drug_dotplot.png | Figure (PNG) | ๐ View |
| Drug Analysis | drug_scores.csv | Data (CSV) | ๐ฅ Download |
| Report | SP454_summary.json | Summary (JSON) | ๐ฅ Download |