Adventitial cells

Adventitial cells are fibroblasts and progenitor cells residing in the adventitia, the outermost connective tissue layer of blood vessels and organs. They are increasingly recognized as key players in vascular biology. They can produce extracellular matrix, sense mechanical and inflammatory signals, differentiate into myofibroblasts, and contribute to vascular remodeling, repair, and the pathogenesis of conditions like atherosclerosis and pulmonary hypertension.