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ESCC-111-12-1A

De-identified Human Immune Atlas donor/sample detail for CancerSCEM 2.0. The record preserves available public metadata while avoiding direct identifiers.

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Donor-Level Analysis Results

Matrix-backed CancerSCEM donor analysis for ESCC-111-12-1A, generated 2026-07-09 12:54:49 +0800.

2,000Cells analyzed
22Clusters
23,352Expressed genes
7556Mean UMI
2216Mean genes
4.177Mean mito %
Donor-level analysis panel
Cluster cell counts, cluster-by-program score heatmap, and top marker genes.
CancerSCEM Deep Analysis Donor JSON UMAP Coordinates UMAP Summary
Gene Program Summary
Program Clusters Mean Score Max Score Genes Used
B_plasma 22 0.3983 2.5181 8
Myeloid_APC 22 0.3645 1.9195 9
Fibroblast_stroma 22 0.3251 2.576 8
T_NK_cytotoxic 22 0.3246 1.6092 10
Endothelial 22 0.2855 2.2802 7
Epithelial_tumor 22 0.1965 2.3964 8
Checkpoint_exhaustion 22 0.1654 0.7558 8
Proliferation 22 0.1606 1.5772 7
Cluster QC
Cluster Cells Mean UMI Median Genes Mean Mito %
cluster_1 224 7098.7098 1738 3.1065
cluster_2 207 7406.7488 2650 6.5382
cluster_3 198 3669.2879 1538 3.7536
cluster_4 172 4607.9477 1645.5 3.6185
cluster_5 163 15796.7117 3856 6.0952
cluster_6 134 6820.806 2396.5 5.1861
cluster_7 117 10621.3504 2906 4.3154
cluster_8 93 5020.957 2021 3.4735
cluster_9 92 5938.7717 2037.5 3.7767
cluster_10 91 9868.2308 2920 4.5057
cluster_11 81 6081.6914 1640 3.2597
cluster_12 75 7977.96 2396 4.5675
cluster_13 73 5632.7671 1876 3.9554
cluster_14 64 7535.6094 1108 3.399
cluster_15 56 8741.4821 2012.5 3.7872
cluster_16 55 872.3636 333 0.7599
cluster_17 41 17422.4634 1755 1.294
cluster_18 27 12680.5556 3698 3.7133
cluster_19 13 6557.6154 2282 3.2082
cluster_20 10 6580.6 1730.5 4.1012
cluster_21 8 8674.875 3293.5 4.6965
cluster_22 6 4772.1667 2184 4.1078
Top Cluster Marker Genes
Cluster Rank Gene Score Mean Expr Detect Fraction
cluster_5 1 KRT14 4.8055 4.9964 0.9632
cluster_17 1 IGHG1 4.4981 4.5902 0.878
cluster_10 1 MGP 4.3677 4.8025 1
cluster_7 1 COL1A1 4.2066 4.4418 0.9915
cluster_14 1 S100A2 3.8462 4.2582 0.9844
cluster_19 1 TPSAB1 3.8377 3.8384 1
cluster_2 1 IGFBP7 3.2418 3.9548 0.9952
cluster_20 1 C1QA 3.1855 3.2615 1
cluster_11 1 IL1B 3.1373 3.5284 0.9259
cluster_21 1 IGFBP7 2.9944 4.031 1
cluster_12 1 IGFBP7 2.9177 3.8569 0.96
cluster_15 1 CD74 2.7974 4.6246 0.9464
cluster_22 1 CRYAB 2.7507 2.9084 1
cluster_18 1 HIST1H4C 2.7472 3.1258 0.9259
cluster_1 1 CXCL8 2.5705 2.9829 0.933
cluster_13 1 GNLY 2.557 2.7762 0.7808
cluster_8 1 GZMB 2.3543 2.7068 0.957
cluster_6 1 IGFBP7 2.3141 3.2076 0.9925
cluster_9 1 IL32 2.2731 3.2825 1
cluster_3 1 CCL5 2.0972 2.4865 0.9343
cluster_16 1 CXCL8 2.0773 2.7205 0.9273
cluster_4 1 SARAF 1.1169 2.232 0.9651
cluster_10 2 DCN 4.218 4.4928 1
cluster_5 2 KRT5 4.1599 4.3185 0.9816
cluster_17 2 JCHAIN 3.812 3.8206 0.9268
cluster_7 2 COL3A1 3.5662 3.8028 0.9829
cluster_14 2 KRT14 3.4788 3.9501 0.9844
cluster_19 2 CPA3 3.2849 3.2859 1
cluster_20 2 SELENOP 3.0207 3.1395 1
cluster_21 2 RAMP2 2.9612 3.3759 1
cluster_18 2 STMN1 2.6733 2.964 0.963
cluster_11 2 TIMP1 2.659 3.7641 0.9753
cluster_22 2 CDH19 2.5735 2.5735 1
cluster_1 2 FTH1 2.5316 5.7669 1
cluster_12 2 SPARC 2.4825 3.2309 0.9333
cluster_2 2 PLVAP 2.3533 2.5192 0.942
cluster_8 2 CCL5 2.3481 2.8358 0.914
cluster_15 2 HLA-DRA 2.3391 3.2011 0.9286
cluster_6 2 SPARCL1 2.2894 2.8009 0.9851
cluster_9 2 TNFRSF4 2.0488 2.1857 0.9565

Primary Metadata

Core de-identified metadata fields migrated from the ImmuneAging donor manifest.

Donor ID
ESCC-111-12-1A
Sample ID
ESCC-111-12-1A
Dataset
CancerSCEM 2.0
Cohort
CancerSCEM 2.0 Chinese subset; Esophageal Squamous Cell Carcinoma
Age / Age Group
Pan-cancer Chinese cohort, per-donor ages not in CancerSCEM metadata
Sex
Not reported in public CancerSCEM metadata
Health Status
Esophageal Squamous Cell Carcinoma; Tumour
Tissue / Cell Source
Tumour
Modality
scRNA-seq (10X Genomics)
Cell Count
3,295
Analysis Status
Matrix available; UMAP generated
UMAP Status
Ready
Metadata / Source Notes
Project ID: ESCC-111; Cancer type: Esophageal Squamous Cell Carcinoma; Source: NCBI (GEO); Accession: GSE160269; Country: CHN; Sample type: Tumour; Protocol: 10X Genomics; Matrix: ESCC-111-12-1A.counts.matrix.tsv.gz (8.70 MB); UMAP: Scanpy-generated donor-level UMAP preview; cells=3295; raw genes=23773; Leiden clusters=22; coordinates TSV and summary JSON are available online.; Age/sex not reported in public CancerSCEM metadata. Age source: CancerSCEM 2.0 database; 400 samples across 47 cancer types; donor-level age not included in download.csv

Additional Clinical / Source Fields

Supplementary source metadata retained from the migrated manifest where available.

cancer type
Esophageal Squamous Cell Carcinoma
cancer type short
ESCC
library count
1
library sample ids
ESCC-111-12-1A
source reference
CancerSCEM 2.0 metadata table; data source=NCBI (GEO); accession=GSE160269; downloaded 2026-07-06
data accession
GSE160269
project id
ESCC-111
sample type
Tumour
country
CHN
data source
NCBI (GEO)
accession no
GSE160269
construction protocol
10X Genomics
transcriptome profile
Yes
metabolic profile
Yes
matrix status
Matrix available
matrix file name
ESCC-111-12-1A.counts.matrix.tsv.gz
matrix file size bytes
9118876
matrix file size mb
8.70
matrix download url
http://8.142.154.29/LACA/data/human_immune_atlas/cancerscem_2_matrix/ESCC-111-12-1A.counts.matrix.tsv.gz
umap coordinates url
http://8.142.154.29/LACA/data/human_immune_atlas/cancerscem_2_umap/ESCC-111-12-1A.umap.tsv.gz
umap summary url
http://8.142.154.29/LACA/data/human_immune_atlas/cancerscem_2_umap/ESCC-111-12-1A.summary.json
umap pipeline
Scanpy 1.9.8 normalize_total/log1p/HVG/PCA/neighbors/leiden/umap; cells=3295; raw_genes=23773; leiden_clusters=22; generated 2026-07-07
matrix integrity status
Gzip readable; UMAP generated