ESCC-111-59-1A
De-identified Human Immune Atlas donor/sample detail for CancerSCEM 2.0. The record preserves available public metadata while avoiding direct identifiers.
Donor-Level Analysis Results
Matrix-backed CancerSCEM donor analysis for ESCC-111-59-1A, generated 2026-07-09 12:54:49 +0800.
2,000Cells analyzed
10Clusters
10,388Expressed genes
1072Mean genes
Gene Program Summary
| Program | Clusters | Mean Score | Max Score | Genes Used |
|---|---|---|---|---|
| Fibroblast_stroma | 10 | 0.6105 | 1.5503 | 3 |
| B_plasma | 10 | 0.5844 | 1.2937 | 4 |
| Myeloid_APC | 10 | 0.2268 | 1.1549 | 7 |
| Proliferation | 10 | 0.0867 | 0.1952 | 2 |
| T_NK_cytotoxic | 10 | 0.0766 | 0.2982 | 3 |
| Checkpoint_exhaustion | 10 | 0.0553 | 0.1364 | 5 |
| Epithelial_tumor | 10 | 0.0203 | 0.071 | 3 |
| Endothelial | 10 | 0.0174 | 0.1416 | 1 |
Cluster QC
| Cluster | Cells | Mean UMI | Median Genes | Mean Mito % |
|---|---|---|---|---|
| cluster_8 | 341 | 1420 | ||
| cluster_10 | 292 | 770 | ||
| cluster_7 | 276 | 733 | ||
| cluster_5 | 243 | 1497 | ||
| cluster_1 | 205 | 1209 | ||
| cluster_4 | 198 | 787 | ||
| cluster_3 | 150 | 1330.5 | ||
| cluster_2 | 139 | 796 | ||
| cluster_9 | 129 | 978 | ||
| cluster_6 | 27 | 1006 |
Top Cluster Marker Genes
| Cluster | Rank | Gene | Score | Mean Expr | Detect Fraction |
|---|---|---|---|---|---|
| cluster_6 | 1 | CXCL8 | 3.5146 | 3.573 | 0.963 |
| cluster_4 | 1 | CD74 | 2.9324 | 4.3519 | 1 |
| cluster_8 | 1 | SFRP2 | 2.4008 | 3.5712 | 0.9971 |
| cluster_3 | 1 | DPT | 2.2739 | 2.6975 | 1 |
| cluster_5 | 1 | CLEC3B | 2.2716 | 3.1368 | 0.9712 |
| cluster_1 | 1 | SFRP2 | 1.9707 | 3.3485 | 0.9805 |
| cluster_9 | 1 | TM4SF1 | 1.8796 | 1.9008 | 0.6899 |
| cluster_10 | 1 | PTPRC | 1.2441 | 1.6954 | 0.9486 |
| cluster_7 | 1 | CYTIP | 1.0197 | 1.41 | 0.8696 |
| cluster_2 | 1 | TNFAIP3 | 0.5327 | 1.2265 | 0.6763 |
| cluster_6 | 2 | IL1B | 3.0563 | 3.061 | 0.7778 |
| cluster_4 | 2 | HLA-DRA | 2.4737 | 3.0746 | 0.9949 |
| cluster_8 | 2 | CLU | 2.2705 | 3.5404 | 0.9971 |
| cluster_3 | 2 | APOD | 2.2631 | 2.6611 | 0.9067 |
| cluster_5 | 2 | PI16 | 2.0289 | 2.9294 | 0.9671 |
| cluster_1 | 2 | ADH1B | 1.7471 | 3.1288 | 0.9463 |
| cluster_9 | 2 | ACKR1 | 1.5218 | 1.5395 | 0.5116 |
| cluster_10 | 2 | EZR | 1.2278 | 2.0694 | 0.9692 |
| cluster_7 | 2 | JCHAIN | 0.9639 | 1.068 | 0.2971 |
| cluster_2 | 2 | CPA3 | 0.4304 | 0.4427 | 0.223 |
| cluster_6 | 3 | CD74 | 2.7776 | 4.4499 | 1 |
| cluster_8 | 3 | IER3 | 2.2414 | 2.9673 | 0.9707 |
| cluster_3 | 3 | C7 | 2.0901 | 2.2208 | 0.86 |
| cluster_5 | 3 | PCOLCE2 | 1.9989 | 2.8862 | 0.9671 |
| cluster_4 | 3 | HLA-DRB1 | 1.7291 | 2.2258 | 0.9949 |
| cluster_1 | 3 | CLU | 1.5445 | 3.0432 | 0.9854 |
| cluster_9 | 3 | IGFBP7 | 1.2117 | 2.0553 | 0.9147 |
| cluster_10 | 3 | CD74 | 1.1176 | 2.6643 | 0.8733 |
| cluster_7 | 3 | CXCR4 | 0.8486 | 1.3437 | 0.7572 |
| cluster_2 | 3 | GATA2 | 0.4037 | 0.4238 | 0.2158 |
| cluster_6 | 4 | HLA-DRA | 2.539 | 3.3505 | 0.9259 |
| cluster_8 | 4 | SOD2 | 2.1302 | 3.1537 | 1 |
| cluster_5 | 4 | IGFBP5 | 1.9973 | 2.9319 | 0.9671 |
| cluster_3 | 4 | SPARCL1 | 1.8863 | 3.0864 | 1 |
| cluster_4 | 4 | HLA-DPA1 | 1.6831 | 2.3301 | 0.9899 |
| cluster_1 | 4 | GPX3 | 1.5411 | 2.7765 | 0.9854 |
| cluster_9 | 4 | ADAMTS9 | 1.187 | 1.1961 | 0.5039 |
| cluster_10 | 4 | CXCR4 | 1.0788 | 1.5335 | 0.9247 |
| cluster_7 | 4 | CD74 | 0.8175 | 2.4145 | 0.8261 |
| cluster_2 | 4 | SYTL3 | 0.3872 | 0.6546 | 0.482 |
Primary Metadata
Core de-identified metadata fields migrated from the ImmuneAging donor manifest.
Donor ID
ESCC-111-59-1A
Sample ID
ESCC-111-59-1A
Dataset
CancerSCEM 2.0
Cohort
CancerSCEM 2.0 Chinese subset; Esophageal Squamous Cell Carcinoma
Age / Age Group
Pan-cancer Chinese cohort, per-donor ages not in CancerSCEM metadata
Sex
Not reported in public CancerSCEM metadata
Health Status
Esophageal Squamous Cell Carcinoma; Normal
Tissue / Cell Source
Normal
Modality
scRNA-seq (10X Genomics)
Cell Count
5,550
Analysis Status
Matrix available; UMAP generated by fallback sampled pipeline
UMAP Status
Ready
Metadata / Source Notes
Project ID: ESCC-111; Cancer type: Esophageal Squamous Cell Carcinoma; Source: NCBI (GEO); Accession: GSE160269; Country: CHN; Sample type: Normal; Protocol: 10X Genomics; Matrix: ESCC-111-59-1A.counts.matrix.tsv.gz (6.50 MB); Matrix integrity: gzip file ended before end-of-stream marker during UMAP generation; redownload required before UMAP can be generated.; Age/sex not reported in public CancerSCEM metadata. Age source: CancerSCEM 2.0 database; 400 samples across 47 cancer types; donor-level age not included in download.csv
Additional Clinical / Source Fields
Supplementary source metadata retained from the migrated manifest where available.
cancer type
Esophageal Squamous Cell Carcinoma
cancer type short
ESCC
library count
1
library sample ids
ESCC-111-59-1A
source reference
CancerSCEM 2.0 metadata table; data source=NCBI (GEO); accession=GSE160269; downloaded 2026-07-06
data accession
GSE160269
project id
ESCC-111
sample type
Normal
country
CHN
data source
NCBI (GEO)
accession no
GSE160269
construction protocol
10X Genomics
transcriptome profile
Yes
metabolic profile
Yes
matrix status
Matrix incomplete; redownload required
matrix file name
ESCC-111-59-1A.counts.matrix.tsv.gz
matrix file size bytes
6815490
matrix file size mb
6.50
umap coordinates url
umap summary url
umap pipeline
Fallback Python normalize_total/log1p/HVG/SVD/UMAP; sampled 3000/5550 cells; generated 2026-07-09
matrix integrity status
Gzip EOF/truncated during UMAP generation