HSCC-130-01-1H
De-identified Human Immune Atlas donor/sample detail for CancerSCEM 2.0. The record preserves available public metadata while avoiding direct identifiers.
Donor-Level Analysis Results
Matrix-backed CancerSCEM donor analysis for HSCC-130-01-1H, generated 2026-07-09 12:54:49 +0800.
2,000Cells analyzed
16Clusters
22,128Expressed genes
6163Mean UMI
1570Mean genes
5.198Mean mito %
Gene Program Summary
| Program | Clusters | Mean Score | Max Score | Genes Used |
|---|---|---|---|---|
| B_plasma | 16 | 1.4471 | 2.7433 | 8 |
| Myeloid_APC | 16 | 0.704 | 2.2541 | 9 |
| T_NK_cytotoxic | 16 | 0.1873 | 0.8159 | 10 |
| Proliferation | 16 | 0.1836 | 0.8934 | 7 |
| Epithelial_tumor | 16 | 0.1516 | 0.9445 | 8 |
| Fibroblast_stroma | 16 | 0.1391 | 1.9152 | 8 |
| Checkpoint_exhaustion | 16 | 0.0798 | 0.2474 | 8 |
| Endothelial | 16 | 0.0564 | 0.1907 | 7 |
Cluster QC
| Cluster | Cells | Mean UMI | Median Genes | Mean Mito % |
|---|---|---|---|---|
| cluster_1 | 381 | 5810.9895 | 789 | 2.8107 |
| cluster_2 | 315 | 7371.527 | 2153 | 5.3634 |
| cluster_3 | 234 | 5411.8632 | 1665.5 | 6.7529 |
| cluster_4 | 187 | 3226.984 | 1245 | 6.2243 |
| cluster_5 | 185 | 7322.3622 | 2055 | 7.5087 |
| cluster_6 | 129 | 6569.1395 | 782 | 2.5868 |
| cluster_7 | 111 | 7640.0721 | 878 | 2.2357 |
| cluster_8 | 110 | 9881.7091 | 2533 | 7.5015 |
| cluster_9 | 90 | 4059.0222 | 1132 | 6.1821 |
| cluster_10 | 66 | 8651.197 | 1962 | 5.2167 |
| cluster_11 | 65 | 4295.8308 | 1620 | 6.3986 |
| cluster_12 | 39 | 3757.8974 | 1435 | 4.644 |
| cluster_13 | 38 | 4871.2105 | 1385 | 6.1417 |
| cluster_14 | 25 | 4587.84 | 1563 | 8.1823 |
| cluster_15 | 17 | 4133.8235 | 1282 | 6.4105 |
| cluster_16 | 8 | 6443 | 1957.5 | 6.3107 |
Top Cluster Marker Genes
| Cluster | Rank | Gene | Score | Mean Expr | Detect Fraction |
|---|---|---|---|---|---|
| cluster_15 | 1 | TPSAB1 | 4.9101 | 4.9353 | 1 |
| cluster_7 | 1 | IGKV3-11 | 4.4988 | 5.0012 | 0.9459 |
| cluster_10 | 1 | SPRR1B | 4.3711 | 4.6224 | 1 |
| cluster_8 | 1 | SPP1 | 4.1051 | 5.5622 | 1 |
| cluster_6 | 1 | IGKV2D-29 | 4.0373 | 4.427 | 0.8992 |
| cluster_12 | 1 | GZMB | 3.3323 | 3.4375 | 1 |
| cluster_2 | 1 | KRT17 | 3.19 | 3.9323 | 1 |
| cluster_5 | 1 | APOE | 2.9338 | 3.548 | 0.9676 |
| cluster_16 | 1 | COL3A1 | 2.7692 | 2.797 | 0.875 |
| cluster_14 | 1 | HLA-DRA | 2.4708 | 3.9849 | 1 |
| cluster_1 | 1 | IGHG1 | 2.4425 | 5.2191 | 0.9974 |
| cluster_3 | 1 | IL1B | 2.0458 | 2.4032 | 0.7949 |
| cluster_11 | 1 | TUBA1B | 1.5755 | 2.5235 | 0.9846 |
| cluster_9 | 1 | MS4A1 | 1.5546 | 1.6869 | 0.9333 |
| cluster_13 | 1 | HIST1H4C | 1.4018 | 1.9779 | 0.9474 |
| cluster_4 | 1 | IL32 | 1.0566 | 1.1696 | 0.7754 |
| cluster_15 | 2 | TPSB2 | 4.5169 | 4.5445 | 1 |
| cluster_10 | 2 | PI3 | 4.2492 | 4.8381 | 0.9848 |
| cluster_7 | 2 | IGKC | 4.0359 | 7.7565 | 1 |
| cluster_6 | 2 | IGKC | 3.7755 | 7.4765 | 1 |
| cluster_8 | 2 | CTSB | 3.1701 | 4.6772 | 1 |
| cluster_5 | 2 | HLA-DRA | 2.7724 | 4.0609 | 1 |
| cluster_16 | 2 | SPARC | 2.6204 | 2.7267 | 1 |
| cluster_14 | 2 | CD74 | 2.4133 | 4.7107 | 1 |
| cluster_2 | 2 | TXN | 2.3447 | 3.4152 | 1 |
| cluster_1 | 2 | IGHG3 | 2.1919 | 4.8251 | 0.9974 |
| cluster_12 | 2 | GPR183 | 2.0817 | 2.7758 | 1 |
| cluster_3 | 2 | TYROBP | 1.9612 | 2.7001 | 1 |
| cluster_11 | 2 | HMGB2 | 1.5473 | 1.8277 | 0.9077 |
| cluster_13 | 2 | HMGB2 | 1.1537 | 1.4624 | 0.9474 |
| cluster_9 | 2 | CD74 | 1.1409 | 3.4171 | 1 |
| cluster_4 | 2 | TRBC2 | 1.028 | 1.2701 | 0.8396 |
| cluster_10 | 3 | S100A9 | 4.0156 | 5.1545 | 1 |
| cluster_7 | 3 | IGHG1 | 3.9081 | 6.9331 | 1 |
| cluster_15 | 3 | CPA3 | 3.9056 | 3.9181 | 1 |
| cluster_6 | 3 | IGHV3-48 | 3.7037 | 4.0157 | 0.9225 |
| cluster_8 | 3 | APOE | 3.1109 | 3.8254 | 0.9909 |
| cluster_5 | 3 | CTSB | 2.7276 | 4.1567 | 1 |
| cluster_16 | 3 | COL1A1 | 2.5428 | 2.5809 | 1 |
| cluster_2 | 3 | AKR1B10 | 2.3066 | 2.5021 | 0.9556 |
Primary Metadata
Core de-identified metadata fields migrated from the ImmuneAging donor manifest.
Donor ID
HSCC-130-01-1H
Sample ID
HSCC-130-01-1H
Dataset
CancerSCEM 2.0
Cohort
CancerSCEM 2.0 Chinese subset; Hypopharygeal Squamous Cell Carcinoma
Age / Age Group
Pan-cancer Chinese cohort, per-donor ages not in CancerSCEM metadata
Sex
Not reported in public CancerSCEM metadata
Health Status
Hypopharygeal Squamous Cell Carcinoma; Tumour
Tissue / Cell Source
Tumour
Modality
scRNA-seq (GEXSCOPE)
Cell Count
7,363
Analysis Status
Matrix available; UMAP generated
UMAP Status
Ready
Metadata / Source Notes
Project ID: HSCC-130; Cancer type: Hypopharygeal Squamous Cell Carcinoma; Source: NCBI (GEO); Accession: GSE227156; Country: CHN; Sample type: Tumour; Protocol: GEXSCOPE; Matrix: HSCC-130-01-1H.counts.matrix.tsv.gz (14.18 MB); UMAP: Scanpy-generated donor-level UMAP preview; cells=7363; raw genes=24280; Leiden clusters=16; coordinates TSV and summary JSON are available online.; Age/sex not reported in public CancerSCEM metadata. Age source: CancerSCEM 2.0 database; 400 samples across 47 cancer types; donor-level age not included in download.csv
Additional Clinical / Source Fields
Supplementary source metadata retained from the migrated manifest where available.
cancer type
Hypopharygeal Squamous Cell Carcinoma
cancer type short
HSCC
library count
1
library sample ids
HSCC-130-01-1H
source reference
CancerSCEM 2.0 metadata table; data source=NCBI (GEO); accession=GSE227156; downloaded 2026-07-06
data accession
GSE227156
project id
HSCC-130
sample type
Tumour
country
CHN
data source
NCBI (GEO)
accession no
GSE227156
construction protocol
GEXSCOPE
transcriptome profile
Yes
metabolic profile
Yes
matrix status
Matrix available
matrix file name
HSCC-130-01-1H.counts.matrix.tsv.gz
matrix file size bytes
14869867
matrix file size mb
14.18
matrix download url
umap coordinates url
umap summary url
umap pipeline
Scanpy 1.9.8 normalize_total/log1p/HVG/PCA/neighbors/leiden/umap; cells=7363; raw_genes=24280; leiden_clusters=16; generated 2026-07-07
matrix integrity status
Gzip readable; UMAP generated