AH4238

MTBLS5568 • Plasma LC-MS metabolomics • Prediabetes whey-protein intervention

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Female Sex
49 yr Age
33.1 BMI
5.2% MRI Pancreas Fat
30 Total Samples (30 POS + 0 NEG)
5 Timepoints: 0, 30, 60, 120, 240 min

Top 15 Metabolite Features (Across All Samples)

L-Leucine

Formula: C6H13NO2 • m/z: 130.0869 • RT: 599.4486
HMDB: HMDB00687 • KEGG: C00123 • Found: 28×
Total abundance
193,573,225

L-Glutamic Acid

Formula: C5H9NO4 • m/z: 146.04542 • RT: 796.2
HMDB: HMDB00148 • KEGG: C00025 • Found: 30×
Total abundance
65,080,667

Methionine sulfoxide

Formula: C5H11NO3S • m/z: 164.03856 • RT: 769.768
HMDB: HMDB02005 • KEGG: C02989 • Found: 30×
Total abundance
24,196,964

Citrulline

Formula: C6H13N3O3 • m/z: 174.08819 • RT: 834.04
HMDB: HMDB00904 • KEGG: C00327 • Found: 30×
Total abundance
20,711,781

L-Tyrosine

Formula: C9H11NO3 • m/z: 180.06659 • RT: 700.038
HMDB: HMDB00158 • KEGG: C00082 • Found: 30×
Total abundance
15,993,828

L-Asparagine

Formula: C4H8N2O3 • m/z: 131.04572 • RT: 821.266
HMDB: HMDB00168 • KEGG: C00152 • Found: 30×
Total abundance
14,731,103

L-Serine

Formula: C3H7NO3 • m/z: 104.03466 • RT: 826.138
HMDB: HMDB00187 • KEGG: C00065 • Found: 30×
Total abundance
14,477,534

L-Isoleucine

Formula: C6H13NO2 • m/z: 133.10592 • RT: 589.6156
HMDB: HMDB00172 • KEGG: C00407 • Found: 28×
Total abundance
12,679,239

Pyridoxamine dihydrochloride

Formula: C8H14Cl2N2O2 • m/z: 133.08047 • RT: 741.336 • Found: 18×
Total abundance
8,172,324

L-Methionine

Formula: C5H11NO2S • m/z: 148.04348 • RT: 640.282
HMDB: HMDB00696 • KEGG: C00073 • Found: 18×
Total abundance
7,463,368

N-Acetylserine

Formula: C5H9NO4 • m/z: 148.06085 • RT: 790.658
HMDB: HMDB02931 • Found: 10×
Total abundance
2,500,635

L-Threonine

Formula: C4H9NO3 • m/z: 119.05372 • RT: 771.834
HMDB: HMDB00165 • KEGG: C00186 • Found: 8×
Total abundance
1,788,230

Leucine

Formula: C6H13NO2 • m/z: 133.10591 • RT: 603.562
HMDB: HMDB00687 • KEGG: C00123 • Found: 4×
Total abundance
1,740,770

2-Methylpropanimidate

Formula: C4H9NO • m/z: 70.06577 • RT: 650.222
HMDB: HMDB0253614 • Found: 6×
Total abundance
1,259,498

Sample Timecourse (30 samples)

WPI Dose: 0 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180201_TOFI2_B1_HILIC_079 1 L-Leucine 3,946,411 L-Glutamic Acid 2,154,327 Citrulline 665,265
0 POS 20180201_TOFI2_B1_HILIC_079 1 L-Leucine 3,946,411 L-Glutamic Acid 2,154,327 Citrulline 665,265
30 POS 20180201_TOFI2_B1_HILIC_080 1 L-Leucine 4,077,225 L-Glutamic Acid 2,107,842 Methionine sulfoxide 750,940
30 POS 20180201_TOFI2_B1_HILIC_080 1 L-Leucine 4,077,225 L-Glutamic Acid 2,107,842 Methionine sulfoxide 750,940
60 POS 20180201_TOFI2_B1_HILIC_081 1 L-Leucine 3,598,900 L-Glutamic Acid 1,985,661 Citrulline 571,692
60 POS 20180201_TOFI2_B1_HILIC_081 1 L-Leucine 3,598,900 L-Glutamic Acid 1,985,661 Citrulline 571,692
120 POS 20180201_TOFI2_B1_HILIC_082 1 L-Leucine 4,097,462 L-Glutamic Acid 2,115,718 Citrulline 577,764
120 POS 20180201_TOFI2_B1_HILIC_082 1 L-Leucine 4,097,462 L-Glutamic Acid 2,115,718 Citrulline 577,764
240 POS 20180201_TOFI2_B1_HILIC_083 1 L-Leucine 3,573,799 L-Glutamic Acid 2,129,540 Methionine sulfoxide 538,175
240 POS 20180201_TOFI2_B1_HILIC_083 1 L-Leucine 3,573,799 L-Glutamic Acid 2,129,540 Methionine sulfoxide 538,175

WPI Dose: 12.5 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180201_TOFI2_B1_HILIC_084 1 L-Leucine 3,356,201 L-Glutamic Acid 2,089,444 Methionine sulfoxide 615,567
0 POS 20180201_TOFI2_B1_HILIC_084 1 L-Leucine 3,356,201 L-Glutamic Acid 2,089,444 Methionine sulfoxide 615,567
30 POS 20180201_TOFI2_B1_HILIC_085 1 L-Leucine 8,793,609 L-Glutamic Acid 2,082,758 Methionine sulfoxide 1,240,212
30 POS 20180201_TOFI2_B1_HILIC_085 1 L-Leucine 8,793,609 L-Glutamic Acid 2,082,758 Methionine sulfoxide 1,240,212
60 POS 20180201_TOFI2_B1_HILIC_086 1 L-Leucine 11,062,963 L-Glutamic Acid 2,188,456 Methionine sulfoxide 1,381,249
60 POS 20180201_TOFI2_B1_HILIC_086 1 L-Leucine 11,062,963 L-Glutamic Acid 2,188,456 Methionine sulfoxide 1,381,249
120 POS 20180201_TOFI2_B1_HILIC_087 1 L-Leucine 5,998,545 L-Glutamic Acid 2,143,424 Citrulline 819,254
120 POS 20180201_TOFI2_B1_HILIC_087 1 L-Leucine 5,998,545 L-Glutamic Acid 2,143,424 Citrulline 819,254
240 POS 20180201_TOFI2_B1_HILIC_088 1 L-Leucine 3,918,615 L-Glutamic Acid 1,961,598 Citrulline 515,679
240 POS 20180201_TOFI2_B1_HILIC_088 1 L-Leucine 3,918,615 L-Glutamic Acid 1,961,598 Citrulline 515,679

WPI Dose: 50 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180201_TOFI2_B1_HILIC_090 1 L-Leucine 3,815,983 L-Glutamic Acid 2,219,091 Methionine sulfoxide 765,620
0 POS 20180201_TOFI2_B1_HILIC_090 1 L-Leucine 3,815,983 L-Glutamic Acid 2,219,091 Methionine sulfoxide 765,620
30 POS 20180201_TOFI2_B1_HILIC_091 1 L-Glutamic Acid 2,120,701 Methionine sulfoxide 1,099,997 L-Asparagine 660,501
30 POS 20180201_TOFI2_B1_HILIC_091 1 L-Glutamic Acid 2,120,701 Methionine sulfoxide 1,099,997 L-Asparagine 660,501
60 POS 20180201_TOFI2_B1_HILIC_092 1 L-Leucine 14,478,115 L-Glutamic Acid 2,521,628 Methionine sulfoxide 1,710,241
60 POS 20180201_TOFI2_B1_HILIC_092 1 L-Leucine 14,478,115 L-Glutamic Acid 2,521,628 Methionine sulfoxide 1,710,241
120 POS 20180201_TOFI2_B1_HILIC_093 1 L-Leucine 15,394,893 L-Glutamic Acid 2,626,981 Citrulline 1,057,122
120 POS 20180201_TOFI2_B1_HILIC_093 1 L-Leucine 15,394,893 L-Glutamic Acid 2,626,981 Citrulline 1,057,122
240 POS 20180201_TOFI2_B1_HILIC_094 1 L-Leucine 10,673,891 L-Glutamic Acid 2,093,165 Citrulline 1,050,761
240 POS 20180201_TOFI2_B1_HILIC_094 1 L-Leucine 10,673,891 L-Glutamic Acid 2,093,165 Citrulline 1,050,761

All Samples

20180201_TOFI2_B1_HILIC_079 POS

Time: 0 min • Dose: 0 g • Batch: 1
L-Leucine 3,946,411
L-Glutamic Acid 2,154,327
Citrulline 665,265
L-Serine 545,883
Pyridoxamine dihydrochloride 462,104

20180201_TOFI2_B1_HILIC_079 POS

Time: 0 min • Dose: 0 g • Batch: 1
L-Leucine 3,946,411
L-Glutamic Acid 2,154,327
Citrulline 665,265
L-Serine 545,883
Pyridoxamine dihydrochloride 462,104

20180201_TOFI2_B1_HILIC_084 POS

Time: 0 min • Dose: 12.5 g • Batch: 1
L-Leucine 3,356,201
L-Glutamic Acid 2,089,444
Methionine sulfoxide 615,567
Citrulline 418,421
L-Serine 374,949

20180201_TOFI2_B1_HILIC_084 POS

Time: 0 min • Dose: 12.5 g • Batch: 1
L-Leucine 3,356,201
L-Glutamic Acid 2,089,444
Methionine sulfoxide 615,567
Citrulline 418,421
L-Serine 374,949

20180201_TOFI2_B1_HILIC_090 POS

Time: 0 min • Dose: 50 g • Batch: 1
L-Leucine 3,815,983
L-Glutamic Acid 2,219,091
Methionine sulfoxide 765,620
Citrulline 548,087
L-Serine 477,335

20180201_TOFI2_B1_HILIC_090 POS

Time: 0 min • Dose: 50 g • Batch: 1
L-Leucine 3,815,983
L-Glutamic Acid 2,219,091
Methionine sulfoxide 765,620
Citrulline 548,087
L-Serine 477,335

20180201_TOFI2_B1_HILIC_080 POS

Time: 30 min • Dose: 0 g • Batch: 1
L-Leucine 4,077,225
L-Glutamic Acid 2,107,842
Methionine sulfoxide 750,940
Citrulline 618,222
L-Serine 530,591

20180201_TOFI2_B1_HILIC_080 POS

Time: 30 min • Dose: 0 g • Batch: 1
L-Leucine 4,077,225
L-Glutamic Acid 2,107,842
Methionine sulfoxide 750,940
Citrulline 618,222
L-Serine 530,591

20180201_TOFI2_B1_HILIC_085 POS

Time: 30 min • Dose: 12.5 g • Batch: 1
L-Leucine 8,793,609
L-Glutamic Acid 2,082,758
Methionine sulfoxide 1,240,212
Citrulline 659,126
L-Asparagine 604,999

20180201_TOFI2_B1_HILIC_085 POS

Time: 30 min • Dose: 12.5 g • Batch: 1
L-Leucine 8,793,609
L-Glutamic Acid 2,082,758
Methionine sulfoxide 1,240,212
Citrulline 659,126
L-Asparagine 604,999

20180201_TOFI2_B1_HILIC_091 POS

Time: 30 min • Dose: 50 g • Batch: 1
L-Glutamic Acid 2,120,701
Methionine sulfoxide 1,099,997
L-Asparagine 660,501
L-Tyrosine 640,477
Citrulline 638,964

20180201_TOFI2_B1_HILIC_091 POS

Time: 30 min • Dose: 50 g • Batch: 1
L-Glutamic Acid 2,120,701
Methionine sulfoxide 1,099,997
L-Asparagine 660,501
L-Tyrosine 640,477
Citrulline 638,964

20180201_TOFI2_B1_HILIC_081 POS

Time: 60 min • Dose: 0 g • Batch: 1
L-Leucine 3,598,900
L-Glutamic Acid 1,985,661
Citrulline 571,692
Methionine sulfoxide 511,421
L-Serine 503,688

20180201_TOFI2_B1_HILIC_081 POS

Time: 60 min • Dose: 0 g • Batch: 1
L-Leucine 3,598,900
L-Glutamic Acid 1,985,661
Citrulline 571,692
Methionine sulfoxide 511,421
L-Serine 503,688

20180201_TOFI2_B1_HILIC_086 POS

Time: 60 min • Dose: 12.5 g • Batch: 1
L-Leucine 11,062,963
L-Glutamic Acid 2,188,456
Methionine sulfoxide 1,381,249
Citrulline 854,999
L-Tyrosine 708,811

20180201_TOFI2_B1_HILIC_086 POS

Time: 60 min • Dose: 12.5 g • Batch: 1
L-Leucine 11,062,963
L-Glutamic Acid 2,188,456
Methionine sulfoxide 1,381,249
Citrulline 854,999
L-Tyrosine 708,811

20180201_TOFI2_B1_HILIC_092 POS

Time: 60 min • Dose: 50 g • Batch: 1
L-Leucine 14,478,115
L-Glutamic Acid 2,521,628
Methionine sulfoxide 1,710,241
L-Isoleucine 939,925
L-Tyrosine 854,438

20180201_TOFI2_B1_HILIC_092 POS

Time: 60 min • Dose: 50 g • Batch: 1
L-Leucine 14,478,115
L-Glutamic Acid 2,521,628
Methionine sulfoxide 1,710,241
L-Isoleucine 939,925
L-Tyrosine 854,438

20180201_TOFI2_B1_HILIC_082 POS

Time: 120 min • Dose: 0 g • Batch: 1
L-Leucine 4,097,462
L-Glutamic Acid 2,115,718
Citrulline 577,764
L-Serine 523,473
Methionine sulfoxide 468,774

20180201_TOFI2_B1_HILIC_082 POS

Time: 120 min • Dose: 0 g • Batch: 1
L-Leucine 4,097,462
L-Glutamic Acid 2,115,718
Citrulline 577,764
L-Serine 523,473
Methionine sulfoxide 468,774

20180201_TOFI2_B1_HILIC_087 POS

Time: 120 min • Dose: 12.5 g • Batch: 1
L-Leucine 5,998,545
L-Glutamic Acid 2,143,424
Citrulline 819,254
Methionine sulfoxide 789,981
L-Tyrosine 518,862

20180201_TOFI2_B1_HILIC_087 POS

Time: 120 min • Dose: 12.5 g • Batch: 1
L-Leucine 5,998,545
L-Glutamic Acid 2,143,424
Citrulline 819,254
Methionine sulfoxide 789,981
L-Tyrosine 518,862

20180201_TOFI2_B1_HILIC_093 POS

Time: 120 min • Dose: 50 g • Batch: 1
L-Leucine 15,394,893
L-Glutamic Acid 2,626,981
Citrulline 1,057,122
L-Isoleucine 982,208
Methionine sulfoxide 963,982

20180201_TOFI2_B1_HILIC_093 POS

Time: 120 min • Dose: 50 g • Batch: 1
L-Leucine 15,394,893
L-Glutamic Acid 2,626,981
Citrulline 1,057,122
L-Isoleucine 982,208
Methionine sulfoxide 963,982

20180201_TOFI2_B1_HILIC_083 POS

Time: 240 min • Dose: 0 g • Batch: 1
L-Leucine 3,573,799
L-Glutamic Acid 2,129,540
Methionine sulfoxide 538,175
Citrulline 526,892
L-Serine 481,677

20180201_TOFI2_B1_HILIC_083 POS

Time: 240 min • Dose: 0 g • Batch: 1
L-Leucine 3,573,799
L-Glutamic Acid 2,129,540
Methionine sulfoxide 538,175
Citrulline 526,892
L-Serine 481,677

20180201_TOFI2_B1_HILIC_088 POS

Time: 240 min • Dose: 12.5 g • Batch: 1
L-Leucine 3,918,615
L-Glutamic Acid 1,961,598
Citrulline 515,679
Methionine sulfoxide 476,731
L-Serine 363,961

20180201_TOFI2_B1_HILIC_088 POS

Time: 240 min • Dose: 12.5 g • Batch: 1
L-Leucine 3,918,615
L-Glutamic Acid 1,961,598
Citrulline 515,679
Methionine sulfoxide 476,731
L-Serine 363,961

20180201_TOFI2_B1_HILIC_094 POS

Time: 240 min • Dose: 50 g • Batch: 1
L-Leucine 10,673,891
L-Glutamic Acid 2,093,165
Citrulline 1,050,761
L-Tyrosine 671,094
L-Isoleucine 663,979

20180201_TOFI2_B1_HILIC_094 POS

Time: 240 min • Dose: 50 g • Batch: 1
L-Leucine 10,673,891
L-Glutamic Acid 2,093,165
Citrulline 1,050,761
L-Tyrosine 671,094
L-Isoleucine 663,979
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