DL4204

MTBLS5568 • Plasma LC-MS metabolomics • Prediabetes whey-protein intervention

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Female Sex
59 yr Age
19.6 BMI
4.7% MRI Pancreas Fat
30 Total Samples (30 POS + 0 NEG)
5 Timepoints: 0, 30, 60, 120, 240 min

Top 15 Metabolite Features (Across All Samples)

L-Leucine

Formula: C6H13NO2 • m/z: 130.0869 • RT: 599.4486
HMDB: HMDB00687 • KEGG: C00123 • Found: 30×
Total abundance
200,701,612

L-Glutamic Acid

Formula: C5H9NO4 • m/z: 146.04542 • RT: 796.2
HMDB: HMDB00148 • KEGG: C00025 • Found: 30×
Total abundance
47,539,377

L-Tyrosine

Formula: C9H11NO3 • m/z: 180.06659 • RT: 700.038
HMDB: HMDB00158 • KEGG: C00082 • Found: 30×
Total abundance
12,115,863

Citrulline

Formula: C6H13N3O3 • m/z: 174.08819 • RT: 834.04
HMDB: HMDB00904 • KEGG: C00327 • Found: 30×
Total abundance
11,681,483

L-Serine

Formula: C3H7NO3 • m/z: 104.03466 • RT: 826.138
HMDB: HMDB00187 • KEGG: C00065 • Found: 30×
Total abundance
10,727,334

L-Isoleucine

Formula: C6H13NO2 • m/z: 133.10592 • RT: 589.6156
HMDB: HMDB00172 • KEGG: C00407 • Found: 28×
Total abundance
10,616,532

L-Methionine

Formula: C5H11NO2S • m/z: 148.04348 • RT: 640.282
HMDB: HMDB00696 • KEGG: C00073 • Found: 30×
Total abundance
10,609,084

Pyridoxamine dihydrochloride

Formula: C8H14Cl2N2O2 • m/z: 133.08047 • RT: 741.336 • Found: 30×
Total abundance
10,481,565

L-Asparagine

Formula: C4H8N2O3 • m/z: 131.04572 • RT: 821.266
HMDB: HMDB00168 • KEGG: C00152 • Found: 28×
Total abundance
9,655,014

Leucine

Formula: C6H13NO2 • m/z: 133.10591 • RT: 603.562
HMDB: HMDB00687 • KEGG: C00123 • Found: 8×
Total abundance
3,103,593

L-Phenylalanine

Formula: C9H11NO2 • m/z: 164.07143 • RT: 595.0478
HMDB: HMDB00159 • KEGG: C00079 • Found: 16×
Total abundance
2,694,772

N-Acetylserine

Formula: C5H9NO4 • m/z: 148.06085 • RT: 790.658
HMDB: HMDB02931 • Found: 4×
Total abundance
758,462

L-2-Aminoadipic acid

Formula: C6H11NO4 • m/z: 162.07635 • RT: 756.777
HMDB: HMDB00510 • KEGG: C00956 • Found: 2×
Total abundance
707,061

Methionine sulfoxide

Formula: C5H11NO3S • m/z: 164.03856 • RT: 769.768
HMDB: HMDB02005 • KEGG: C02989 • Found: 4×
Total abundance
571,755

Sample Timecourse (30 samples)

WPI Dose: 0 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180212_TOFI2_B3_HILIC_046 3 L-Leucine 2,367,241 L-Glutamic Acid 1,548,298 L-Serine 303,504
0 POS 20180212_TOFI2_B3_HILIC_046 3 L-Leucine 2,367,241 L-Glutamic Acid 1,548,298 L-Serine 303,504
30 POS 20180212_TOFI2_B3_HILIC_047 3 L-Leucine 2,509,933 L-Glutamic Acid 1,551,522 L-Serine 328,821
30 POS 20180212_TOFI2_B3_HILIC_047 3 L-Leucine 2,509,933 L-Glutamic Acid 1,551,522 L-Serine 328,821
60 POS 20180212_TOFI2_B3_HILIC_048 3 L-Leucine 2,928,096 L-Glutamic Acid 1,478,512 Pyridoxamine dihydrochloride 301,388
60 POS 20180212_TOFI2_B3_HILIC_048 3 L-Leucine 2,928,096 L-Glutamic Acid 1,478,512 Pyridoxamine dihydrochloride 301,388
120 POS 20180212_TOFI2_B3_HILIC_049 3 L-Leucine 2,642,368 L-Glutamic Acid 1,518,283 L-Serine 308,190
120 POS 20180212_TOFI2_B3_HILIC_049 3 L-Leucine 2,642,368 L-Glutamic Acid 1,518,283 L-Serine 308,190
240 POS 20180212_TOFI2_B3_HILIC_050 3 L-Leucine 2,888,379 L-Glutamic Acid 1,464,619 L-Serine 304,673
240 POS 20180212_TOFI2_B3_HILIC_050 3 L-Leucine 2,888,379 L-Glutamic Acid 1,464,619 L-Serine 304,673

WPI Dose: 12.5 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180212_TOFI2_B3_HILIC_051 3 L-Leucine 2,835,208 L-Glutamic Acid 1,535,286 L-Serine 347,697
0 POS 20180212_TOFI2_B3_HILIC_051 3 L-Leucine 2,835,208 L-Glutamic Acid 1,535,286 L-Serine 347,697
30 POS 20180212_TOFI2_B3_HILIC_052 3 L-Leucine 9,797,225 L-Glutamic Acid 1,657,163 L-Isoleucine 500,725
30 POS 20180212_TOFI2_B3_HILIC_052 3 L-Leucine 9,797,225 L-Glutamic Acid 1,657,163 L-Isoleucine 500,725
60 POS 20180212_TOFI2_B3_HILIC_053 3 L-Leucine 9,445,847 L-Glutamic Acid 1,681,964 L-Isoleucine 552,053
60 POS 20180212_TOFI2_B3_HILIC_053 3 L-Leucine 9,445,847 L-Glutamic Acid 1,681,964 L-Isoleucine 552,053
120 POS 20180212_TOFI2_B3_HILIC_054 3 L-Leucine 3,845,656 L-Glutamic Acid 1,554,036 Citrulline 423,054
120 POS 20180212_TOFI2_B3_HILIC_054 3 L-Leucine 3,845,656 L-Glutamic Acid 1,554,036 Citrulline 423,054
240 POS 20180212_TOFI2_B3_HILIC_055 3 L-Leucine 3,333,967 L-Glutamic Acid 1,603,344 L-Serine 321,309
240 POS 20180212_TOFI2_B3_HILIC_055 3 L-Leucine 3,333,967 L-Glutamic Acid 1,603,344 L-Serine 321,309

WPI Dose: 50 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180212_TOFI2_B3_HILIC_057 3 L-Leucine 2,389,612 L-Glutamic Acid 1,421,568 Pyridoxamine dihydrochloride 356,654
0 POS 20180212_TOFI2_B3_HILIC_057 3 L-Leucine 2,389,612 L-Glutamic Acid 1,421,568 Pyridoxamine dihydrochloride 356,654
30 POS 20180212_TOFI2_B3_HILIC_058 3 L-Leucine 9,330,290 L-Glutamic Acid 1,542,114 L-Isoleucine 562,131
30 POS 20180212_TOFI2_B3_HILIC_058 3 L-Leucine 9,330,290 L-Glutamic Acid 1,542,114 L-Isoleucine 562,131
60 POS 20180212_TOFI2_B3_HILIC_059 3 L-Leucine 19,924,345 L-Glutamic Acid 1,856,445 L-Isoleucine 751,878
60 POS 20180212_TOFI2_B3_HILIC_059 3 L-Leucine 19,924,345 L-Glutamic Acid 1,856,445 L-Isoleucine 751,878
120 POS 20180212_TOFI2_B3_HILIC_060 3 L-Leucine 20,060,672 L-Glutamic Acid 1,817,895 L-Isoleucine 1,282,686
120 POS 20180212_TOFI2_B3_HILIC_060 3 L-Leucine 20,060,672 L-Glutamic Acid 1,817,895 L-Isoleucine 1,282,686
240 POS 20180212_TOFI2_B3_HILIC_061 3 L-Leucine 6,051,965 L-Glutamic Acid 1,538,639 L-Tyrosine 581,966
240 POS 20180212_TOFI2_B3_HILIC_061 3 L-Leucine 6,051,965 L-Glutamic Acid 1,538,639 L-Tyrosine 581,966

All Samples

20180212_TOFI2_B3_HILIC_046 POS

Time: 0 min • Dose: 0 g • Batch: 3
L-Leucine 2,367,241
L-Glutamic Acid 1,548,298
L-Serine 303,504
Pyridoxamine dihydrochloride 295,339
Citrulline 292,182

20180212_TOFI2_B3_HILIC_046 POS

Time: 0 min • Dose: 0 g • Batch: 3
L-Leucine 2,367,241
L-Glutamic Acid 1,548,298
L-Serine 303,504
Pyridoxamine dihydrochloride 295,339
Citrulline 292,182

20180212_TOFI2_B3_HILIC_051 POS

Time: 0 min • Dose: 12.5 g • Batch: 3
L-Leucine 2,835,208
L-Glutamic Acid 1,535,286
L-Serine 347,697
Citrulline 301,829
Pyridoxamine dihydrochloride 278,066

20180212_TOFI2_B3_HILIC_051 POS

Time: 0 min • Dose: 12.5 g • Batch: 3
L-Leucine 2,835,208
L-Glutamic Acid 1,535,286
L-Serine 347,697
Citrulline 301,829
Pyridoxamine dihydrochloride 278,066

20180212_TOFI2_B3_HILIC_057 POS

Time: 0 min • Dose: 50 g • Batch: 3
L-Leucine 2,389,612
L-Glutamic Acid 1,421,568
Pyridoxamine dihydrochloride 356,654
Citrulline 318,540
L-Serine 307,436

20180212_TOFI2_B3_HILIC_057 POS

Time: 0 min • Dose: 50 g • Batch: 3
L-Leucine 2,389,612
L-Glutamic Acid 1,421,568
Pyridoxamine dihydrochloride 356,654
Citrulline 318,540
L-Serine 307,436

20180212_TOFI2_B3_HILIC_047 POS

Time: 30 min • Dose: 0 g • Batch: 3
L-Leucine 2,509,933
L-Glutamic Acid 1,551,522
L-Serine 328,821
Pyridoxamine dihydrochloride 318,813
Citrulline 280,036

20180212_TOFI2_B3_HILIC_047 POS

Time: 30 min • Dose: 0 g • Batch: 3
L-Leucine 2,509,933
L-Glutamic Acid 1,551,522
L-Serine 328,821
Pyridoxamine dihydrochloride 318,813
Citrulline 280,036

20180212_TOFI2_B3_HILIC_052 POS

Time: 30 min • Dose: 12.5 g • Batch: 3
L-Leucine 9,797,225
L-Glutamic Acid 1,657,163
L-Isoleucine 500,725
L-Asparagine 496,769
L-Methionine 483,152

20180212_TOFI2_B3_HILIC_052 POS

Time: 30 min • Dose: 12.5 g • Batch: 3
L-Leucine 9,797,225
L-Glutamic Acid 1,657,163
L-Isoleucine 500,725
L-Asparagine 496,769
L-Methionine 483,152

20180212_TOFI2_B3_HILIC_058 POS

Time: 30 min • Dose: 50 g • Batch: 3
L-Leucine 9,330,290
L-Glutamic Acid 1,542,114
L-Isoleucine 562,131
Pyridoxamine dihydrochloride 491,629
L-Tyrosine 478,677

20180212_TOFI2_B3_HILIC_058 POS

Time: 30 min • Dose: 50 g • Batch: 3
L-Leucine 9,330,290
L-Glutamic Acid 1,542,114
L-Isoleucine 562,131
Pyridoxamine dihydrochloride 491,629
L-Tyrosine 478,677

20180212_TOFI2_B3_HILIC_048 POS

Time: 60 min • Dose: 0 g • Batch: 3
L-Leucine 2,928,096
L-Glutamic Acid 1,478,512
Pyridoxamine dihydrochloride 301,388
L-Serine 300,825
Citrulline 263,373

20180212_TOFI2_B3_HILIC_048 POS

Time: 60 min • Dose: 0 g • Batch: 3
L-Leucine 2,928,096
L-Glutamic Acid 1,478,512
Pyridoxamine dihydrochloride 301,388
L-Serine 300,825
Citrulline 263,373

20180212_TOFI2_B3_HILIC_053 POS

Time: 60 min • Dose: 12.5 g • Batch: 3
L-Leucine 9,445,847
L-Glutamic Acid 1,681,964
L-Isoleucine 552,053
L-Tyrosine 537,826
Citrulline 512,829

20180212_TOFI2_B3_HILIC_053 POS

Time: 60 min • Dose: 12.5 g • Batch: 3
L-Leucine 9,445,847
L-Glutamic Acid 1,681,964
L-Isoleucine 552,053
L-Tyrosine 537,826
Citrulline 512,829

20180212_TOFI2_B3_HILIC_059 POS

Time: 60 min • Dose: 50 g • Batch: 3
L-Leucine 19,924,345
L-Glutamic Acid 1,856,445
L-Isoleucine 751,878
L-Tyrosine 724,866
L-Methionine 671,998

20180212_TOFI2_B3_HILIC_059 POS

Time: 60 min • Dose: 50 g • Batch: 3
L-Leucine 19,924,345
L-Glutamic Acid 1,856,445
L-Isoleucine 751,878
L-Tyrosine 724,866
L-Methionine 671,998

20180212_TOFI2_B3_HILIC_049 POS

Time: 120 min • Dose: 0 g • Batch: 3
L-Leucine 2,642,368
L-Glutamic Acid 1,518,283
L-Serine 308,190
Pyridoxamine dihydrochloride 260,145
Citrulline 251,124

20180212_TOFI2_B3_HILIC_049 POS

Time: 120 min • Dose: 0 g • Batch: 3
L-Leucine 2,642,368
L-Glutamic Acid 1,518,283
L-Serine 308,190
Pyridoxamine dihydrochloride 260,145
Citrulline 251,124

20180212_TOFI2_B3_HILIC_054 POS

Time: 120 min • Dose: 12.5 g • Batch: 3
L-Leucine 3,845,656
L-Glutamic Acid 1,554,036
Citrulline 423,054
L-Serine 340,436
Pyridoxamine dihydrochloride 307,566

20180212_TOFI2_B3_HILIC_054 POS

Time: 120 min • Dose: 12.5 g • Batch: 3
L-Leucine 3,845,656
L-Glutamic Acid 1,554,036
Citrulline 423,054
L-Serine 340,436
Pyridoxamine dihydrochloride 307,566

20180212_TOFI2_B3_HILIC_060 POS

Time: 120 min • Dose: 50 g • Batch: 3
L-Leucine 20,060,672
L-Glutamic Acid 1,817,895
L-Isoleucine 1,282,686
L-Tyrosine 1,151,015
L-Methionine 1,122,058

20180212_TOFI2_B3_HILIC_060 POS

Time: 120 min • Dose: 50 g • Batch: 3
L-Leucine 20,060,672
L-Glutamic Acid 1,817,895
L-Isoleucine 1,282,686
L-Tyrosine 1,151,015
L-Methionine 1,122,058

20180212_TOFI2_B3_HILIC_050 POS

Time: 240 min • Dose: 0 g • Batch: 3
L-Leucine 2,888,379
L-Glutamic Acid 1,464,619
L-Serine 304,673
Citrulline 260,438
Pyridoxamine dihydrochloride 258,832

20180212_TOFI2_B3_HILIC_050 POS

Time: 240 min • Dose: 0 g • Batch: 3
L-Leucine 2,888,379
L-Glutamic Acid 1,464,619
L-Serine 304,673
Citrulline 260,438
Pyridoxamine dihydrochloride 258,832

20180212_TOFI2_B3_HILIC_055 POS

Time: 240 min • Dose: 12.5 g • Batch: 3
L-Leucine 3,333,967
L-Glutamic Acid 1,603,344
L-Serine 321,309
Citrulline 301,849
Pyridoxamine dihydrochloride 244,863

20180212_TOFI2_B3_HILIC_055 POS

Time: 240 min • Dose: 12.5 g • Batch: 3
L-Leucine 3,333,967
L-Glutamic Acid 1,603,344
L-Serine 321,309
Citrulline 301,849
Pyridoxamine dihydrochloride 244,863

20180212_TOFI2_B3_HILIC_061 POS

Time: 240 min • Dose: 50 g • Batch: 3
L-Leucine 6,051,965
L-Glutamic Acid 1,538,639
L-Tyrosine 581,966
Citrulline 580,350
L-Methionine 387,510

20180212_TOFI2_B3_HILIC_061 POS

Time: 240 min • Dose: 50 g • Batch: 3
L-Leucine 6,051,965
L-Glutamic Acid 1,538,639
L-Tyrosine 581,966
Citrulline 580,350
L-Methionine 387,510
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