XZ4231

MTBLS5568 • Plasma LC-MS metabolomics • Prediabetes whey-protein intervention

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Female Sex
54 yr Age
23.4 BMI
5% MRI Pancreas Fat
30 Total Samples (30 POS + 0 NEG)
5 Timepoints: 0, 30, 60, 120, 240 min

Top 15 Metabolite Features (Across All Samples)

L-Leucine

Formula: C6H13NO2 • m/z: 130.0869 • RT: 599.4486
HMDB: HMDB00687 • KEGG: C00123 • Found: 30×
Total abundance
171,848,011

L-Glutamic Acid

Formula: C5H9NO4 • m/z: 146.04542 • RT: 796.2
HMDB: HMDB00148 • KEGG: C00025 • Found: 30×
Total abundance
46,878,806

L-Tyrosine

Formula: C9H11NO3 • m/z: 180.06659 • RT: 700.038
HMDB: HMDB00158 • KEGG: C00082 • Found: 30×
Total abundance
14,791,394

L-Serine

Formula: C3H7NO3 • m/z: 104.03466 • RT: 826.138
HMDB: HMDB00187 • KEGG: C00065 • Found: 30×
Total abundance
14,630,327

Citrulline

Formula: C6H13N3O3 • m/z: 174.08819 • RT: 834.04
HMDB: HMDB00904 • KEGG: C00327 • Found: 30×
Total abundance
14,050,052

Pyridoxamine dihydrochloride

Formula: C8H14Cl2N2O2 • m/z: 133.08047 • RT: 741.336 • Found: 28×
Total abundance
11,552,574

L-Asparagine

Formula: C4H8N2O3 • m/z: 131.04572 • RT: 821.266
HMDB: HMDB00168 • KEGG: C00152 • Found: 28×
Total abundance
10,436,604

L-Isoleucine

Formula: C6H13NO2 • m/z: 133.10592 • RT: 589.6156
HMDB: HMDB00172 • KEGG: C00407 • Found: 18×
Total abundance
9,529,817

L-Methionine

Formula: C5H11NO2S • m/z: 148.04348 • RT: 640.282
HMDB: HMDB00696 • KEGG: C00073 • Found: 28×
Total abundance
9,070,639

Methionine sulfoxide

Formula: C5H11NO3S • m/z: 164.03856 • RT: 769.768
HMDB: HMDB02005 • KEGG: C02989 • Found: 26×
Total abundance
7,912,414

N-Acetylserine

Formula: C5H9NO4 • m/z: 148.06085 • RT: 790.658
HMDB: HMDB02931 • Found: 22×
Total abundance
6,497,170

Sample Timecourse (30 samples)

WPI Dose: 12.5 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180220_TOFI2_B4_HILIC_013 4 L-Leucine 2,180,937 L-Glutamic Acid 1,399,033 L-Serine 441,089
0 POS 20180220_TOFI2_B4_HILIC_013 4 L-Leucine 2,180,937 L-Glutamic Acid 1,399,033 L-Serine 441,089
30 POS 20180220_TOFI2_B4_HILIC_014 4 L-Leucine 7,298,698 L-Glutamic Acid 1,594,705 L-Serine 579,648
30 POS 20180220_TOFI2_B4_HILIC_014 4 L-Leucine 7,298,698 L-Glutamic Acid 1,594,705 L-Serine 579,648
60 POS 20180220_TOFI2_B4_HILIC_015 4 L-Leucine 7,944,065 L-Glutamic Acid 1,730,784 Citrulline 609,286
60 POS 20180220_TOFI2_B4_HILIC_015 4 L-Leucine 7,944,065 L-Glutamic Acid 1,730,784 Citrulline 609,286
120 POS 20180220_TOFI2_B4_HILIC_016 4 L-Leucine 3,571,108 L-Glutamic Acid 1,522,940 Pyridoxamine dihydrochloride 399,883
120 POS 20180220_TOFI2_B4_HILIC_016 4 L-Leucine 3,571,108 L-Glutamic Acid 1,522,940 Pyridoxamine dihydrochloride 399,883
240 POS 20180220_TOFI2_B4_HILIC_017 4 L-Leucine 3,281,951 L-Glutamic Acid 1,404,661 L-Serine 410,018
240 POS 20180220_TOFI2_B4_HILIC_017 4 L-Leucine 3,281,951 L-Glutamic Acid 1,404,661 L-Serine 410,018

WPI Dose: 50 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180220_TOFI2_B4_HILIC_018 4 L-Leucine 2,451,674 L-Glutamic Acid 1,476,055 L-Serine 453,812
0 POS 20180220_TOFI2_B4_HILIC_018 4 L-Leucine 2,451,674 L-Glutamic Acid 1,476,055 L-Serine 453,812
30 POS 20180220_TOFI2_B4_HILIC_019 4 L-Leucine 12,182,080 L-Glutamic Acid 1,731,799 L-Tyrosine 768,482
30 POS 20180220_TOFI2_B4_HILIC_019 4 L-Leucine 12,182,080 L-Glutamic Acid 1,731,799 L-Tyrosine 768,482
60 POS 20180220_TOFI2_B4_HILIC_020 4 L-Leucine 13,022,789 L-Glutamic Acid 1,880,727 L-Tyrosine 1,068,236
60 POS 20180220_TOFI2_B4_HILIC_020 4 L-Leucine 13,022,789 L-Glutamic Acid 1,880,727 L-Tyrosine 1,068,236
120 POS 20180220_TOFI2_B4_HILIC_021 4 L-Leucine 16,591,517 L-Glutamic Acid 1,917,779 L-Tyrosine 1,286,131
120 POS 20180220_TOFI2_B4_HILIC_021 4 L-Leucine 16,591,517 L-Glutamic Acid 1,917,779 L-Tyrosine 1,286,131
240 POS 20180220_TOFI2_B4_HILIC_022 4 L-Leucine 7,097,541 L-Glutamic Acid 1,467,296 Citrulline 668,931
240 POS 20180220_TOFI2_B4_HILIC_022 4 L-Leucine 7,097,541 L-Glutamic Acid 1,467,296 Citrulline 668,931

WPI Dose: 0 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180220_TOFI2_B4_HILIC_024 4 L-Leucine 2,120,033 L-Glutamic Acid 1,508,605 L-Serine 436,586
0 POS 20180220_TOFI2_B4_HILIC_024 4 L-Leucine 2,120,033 L-Glutamic Acid 1,508,605 L-Serine 436,586
30 POS 20180220_TOFI2_B4_HILIC_025 4 L-Leucine 2,012,549 L-Glutamic Acid 1,391,353 L-Serine 405,554
30 POS 20180220_TOFI2_B4_HILIC_025 4 L-Leucine 2,012,549 L-Glutamic Acid 1,391,353 L-Serine 405,554
60 POS 20180220_TOFI2_B4_HILIC_026 4 L-Leucine 2,017,219 L-Glutamic Acid 1,424,125 L-Serine 402,132
60 POS 20180220_TOFI2_B4_HILIC_026 4 L-Leucine 2,017,219 L-Glutamic Acid 1,424,125 L-Serine 402,132
120 POS 20180220_TOFI2_B4_HILIC_027 4 L-Leucine 2,106,805 L-Glutamic Acid 1,471,289 L-Serine 403,295
120 POS 20180220_TOFI2_B4_HILIC_027 4 L-Leucine 2,106,805 L-Glutamic Acid 1,471,289 L-Serine 403,295
240 POS 20180220_TOFI2_B4_HILIC_028 4 L-Leucine 2,045,039 L-Glutamic Acid 1,518,250 L-Serine 416,078
240 POS 20180220_TOFI2_B4_HILIC_028 4 L-Leucine 2,045,039 L-Glutamic Acid 1,518,250 L-Serine 416,078

All Samples

20180220_TOFI2_B4_HILIC_013 POS

Time: 0 min • Dose: 12.5 g • Batch: 4
L-Leucine 2,180,937
L-Glutamic Acid 1,399,033
L-Serine 441,089
Pyridoxamine dihydrochloride 374,685
Citrulline 278,601

20180220_TOFI2_B4_HILIC_013 POS

Time: 0 min • Dose: 12.5 g • Batch: 4
L-Leucine 2,180,937
L-Glutamic Acid 1,399,033
L-Serine 441,089
Pyridoxamine dihydrochloride 374,685
Citrulline 278,601

20180220_TOFI2_B4_HILIC_018 POS

Time: 0 min • Dose: 50 g • Batch: 4
L-Leucine 2,451,674
L-Glutamic Acid 1,476,055
L-Serine 453,812
Pyridoxamine dihydrochloride 376,171
L-Tyrosine 317,078

20180220_TOFI2_B4_HILIC_018 POS

Time: 0 min • Dose: 50 g • Batch: 4
L-Leucine 2,451,674
L-Glutamic Acid 1,476,055
L-Serine 453,812
Pyridoxamine dihydrochloride 376,171
L-Tyrosine 317,078

20180220_TOFI2_B4_HILIC_024 POS

Time: 0 min • Dose: 0 g • Batch: 4
L-Leucine 2,120,033
L-Glutamic Acid 1,508,605
L-Serine 436,586
Citrulline 356,797
Pyridoxamine dihydrochloride 303,197

20180220_TOFI2_B4_HILIC_024 POS

Time: 0 min • Dose: 0 g • Batch: 4
L-Leucine 2,120,033
L-Glutamic Acid 1,508,605
L-Serine 436,586
Citrulline 356,797
Pyridoxamine dihydrochloride 303,197

20180220_TOFI2_B4_HILIC_014 POS

Time: 30 min • Dose: 12.5 g • Batch: 4
L-Leucine 7,298,698
L-Glutamic Acid 1,594,705
L-Serine 579,648
Pyridoxamine dihydrochloride 522,081
L-Tyrosine 521,550

20180220_TOFI2_B4_HILIC_014 POS

Time: 30 min • Dose: 12.5 g • Batch: 4
L-Leucine 7,298,698
L-Glutamic Acid 1,594,705
L-Serine 579,648
Pyridoxamine dihydrochloride 522,081
L-Tyrosine 521,550

20180220_TOFI2_B4_HILIC_019 POS

Time: 30 min • Dose: 50 g • Batch: 4
L-Leucine 12,182,080
L-Glutamic Acid 1,731,799
L-Tyrosine 768,482
L-Isoleucine 738,409
L-Serine 672,186

20180220_TOFI2_B4_HILIC_019 POS

Time: 30 min • Dose: 50 g • Batch: 4
L-Leucine 12,182,080
L-Glutamic Acid 1,731,799
L-Tyrosine 768,482
L-Isoleucine 738,409
L-Serine 672,186

20180220_TOFI2_B4_HILIC_025 POS

Time: 30 min • Dose: 0 g • Batch: 4
L-Leucine 2,012,549
L-Glutamic Acid 1,391,353
L-Serine 405,554
Pyridoxamine dihydrochloride 376,776
Citrulline 302,758

20180220_TOFI2_B4_HILIC_025 POS

Time: 30 min • Dose: 0 g • Batch: 4
L-Leucine 2,012,549
L-Glutamic Acid 1,391,353
L-Serine 405,554
Pyridoxamine dihydrochloride 376,776
Citrulline 302,758

20180220_TOFI2_B4_HILIC_015 POS

Time: 60 min • Dose: 12.5 g • Batch: 4
L-Leucine 7,944,065
L-Glutamic Acid 1,730,784
Citrulline 609,286
L-Serine 584,238
L-Tyrosine 576,051

20180220_TOFI2_B4_HILIC_015 POS

Time: 60 min • Dose: 12.5 g • Batch: 4
L-Leucine 7,944,065
L-Glutamic Acid 1,730,784
Citrulline 609,286
L-Serine 584,238
L-Tyrosine 576,051

20180220_TOFI2_B4_HILIC_020 POS

Time: 60 min • Dose: 50 g • Batch: 4
L-Leucine 13,022,789
L-Glutamic Acid 1,880,727
L-Tyrosine 1,068,236
L-Isoleucine 828,726
Citrulline 768,815

20180220_TOFI2_B4_HILIC_020 POS

Time: 60 min • Dose: 50 g • Batch: 4
L-Leucine 13,022,789
L-Glutamic Acid 1,880,727
L-Tyrosine 1,068,236
L-Isoleucine 828,726
Citrulline 768,815

20180220_TOFI2_B4_HILIC_026 POS

Time: 60 min • Dose: 0 g • Batch: 4
L-Leucine 2,017,219
L-Glutamic Acid 1,424,125
L-Serine 402,132
Pyridoxamine dihydrochloride 306,776
Citrulline 287,693

20180220_TOFI2_B4_HILIC_026 POS

Time: 60 min • Dose: 0 g • Batch: 4
L-Leucine 2,017,219
L-Glutamic Acid 1,424,125
L-Serine 402,132
Pyridoxamine dihydrochloride 306,776
Citrulline 287,693

20180220_TOFI2_B4_HILIC_016 POS

Time: 120 min • Dose: 12.5 g • Batch: 4
L-Leucine 3,571,108
L-Glutamic Acid 1,522,940
Pyridoxamine dihydrochloride 399,883
L-Serine 399,437
Citrulline 393,132

20180220_TOFI2_B4_HILIC_016 POS

Time: 120 min • Dose: 12.5 g • Batch: 4
L-Leucine 3,571,108
L-Glutamic Acid 1,522,940
Pyridoxamine dihydrochloride 399,883
L-Serine 399,437
Citrulline 393,132

20180220_TOFI2_B4_HILIC_021 POS

Time: 120 min • Dose: 50 g • Batch: 4
L-Leucine 16,591,517
L-Glutamic Acid 1,917,779
L-Tyrosine 1,286,131
L-Isoleucine 1,239,960
Citrulline 1,159,633

20180220_TOFI2_B4_HILIC_021 POS

Time: 120 min • Dose: 50 g • Batch: 4
L-Leucine 16,591,517
L-Glutamic Acid 1,917,779
L-Tyrosine 1,286,131
L-Isoleucine 1,239,960
Citrulline 1,159,633

20180220_TOFI2_B4_HILIC_027 POS

Time: 120 min • Dose: 0 g • Batch: 4
L-Leucine 2,106,805
L-Glutamic Acid 1,471,289
L-Serine 403,295
Pyridoxamine dihydrochloride 337,962
Citrulline 292,322

20180220_TOFI2_B4_HILIC_027 POS

Time: 120 min • Dose: 0 g • Batch: 4
L-Leucine 2,106,805
L-Glutamic Acid 1,471,289
L-Serine 403,295
Pyridoxamine dihydrochloride 337,962
Citrulline 292,322

20180220_TOFI2_B4_HILIC_017 POS

Time: 240 min • Dose: 12.5 g • Batch: 4
L-Leucine 3,281,951
L-Glutamic Acid 1,404,661
L-Serine 410,018
Pyridoxamine dihydrochloride 407,857
Citrulline 342,298

20180220_TOFI2_B4_HILIC_017 POS

Time: 240 min • Dose: 12.5 g • Batch: 4
L-Leucine 3,281,951
L-Glutamic Acid 1,404,661
L-Serine 410,018
Pyridoxamine dihydrochloride 407,857
Citrulline 342,298

20180220_TOFI2_B4_HILIC_022 POS

Time: 240 min • Dose: 50 g • Batch: 4
L-Leucine 7,097,541
L-Glutamic Acid 1,467,296
Citrulline 668,931
L-Tyrosine 588,308
Pyridoxamine dihydrochloride 427,516

20180220_TOFI2_B4_HILIC_022 POS

Time: 240 min • Dose: 50 g • Batch: 4
L-Leucine 7,097,541
L-Glutamic Acid 1,467,296
Citrulline 668,931
L-Tyrosine 588,308
Pyridoxamine dihydrochloride 427,516

20180220_TOFI2_B4_HILIC_028 POS

Time: 240 min • Dose: 0 g • Batch: 4
L-Leucine 2,045,039
L-Glutamic Acid 1,518,250
L-Serine 416,078
Pyridoxamine dihydrochloride 338,982
Citrulline 322,416

20180220_TOFI2_B4_HILIC_028 POS

Time: 240 min • Dose: 0 g • Batch: 4
L-Leucine 2,045,039
L-Glutamic Acid 1,518,250
L-Serine 416,078
Pyridoxamine dihydrochloride 338,982
Citrulline 322,416
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