VW4245

MTBLS5568 • Plasma LC-MS metabolomics • Prediabetes whey-protein intervention

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Female Sex
26 yr Age
31.5 BMI
2.9% MRI Pancreas Fat
30 Total Samples (30 POS + 0 NEG)
5 Timepoints: 0, 30, 60, 120, 240 min

Top 15 Metabolite Features (Across All Samples)

L-Leucine

Formula: C6H13NO2 • m/z: 130.0869 • RT: 599.4486
HMDB: HMDB00687 • KEGG: C00123 • Found: 30×
Total abundance
245,866,230

L-Glutamic Acid

Formula: C5H9NO4 • m/z: 146.04542 • RT: 796.2
HMDB: HMDB00148 • KEGG: C00025 • Found: 30×
Total abundance
76,337,333

L-Asparagine

Formula: C4H8N2O3 • m/z: 131.04572 • RT: 821.266
HMDB: HMDB00168 • KEGG: C00152 • Found: 30×
Total abundance
21,248,499

Citrulline

Formula: C6H13N3O3 • m/z: 174.08819 • RT: 834.04
HMDB: HMDB00904 • KEGG: C00327 • Found: 30×
Total abundance
19,952,110

L-Serine

Formula: C3H7NO3 • m/z: 104.03466 • RT: 826.138
HMDB: HMDB00187 • KEGG: C00065 • Found: 30×
Total abundance
18,280,851

L-Tyrosine

Formula: C9H11NO3 • m/z: 180.06659 • RT: 700.038
HMDB: HMDB00158 • KEGG: C00082 • Found: 30×
Total abundance
17,688,335

L-Isoleucine

Formula: C6H13NO2 • m/z: 133.10592 • RT: 589.6156
HMDB: HMDB00172 • KEGG: C00407 • Found: 30×
Total abundance
15,592,812

Pyridoxamine dihydrochloride

Formula: C8H14Cl2N2O2 • m/z: 133.08047 • RT: 741.336 • Found: 26×
Total abundance
15,093,759

L-Methionine

Formula: C5H11NO2S • m/z: 148.04348 • RT: 640.282
HMDB: HMDB00696 • KEGG: C00073 • Found: 28×
Total abundance
11,006,002

Methionine sulfoxide

Formula: C5H11NO3S • m/z: 164.03856 • RT: 769.768
HMDB: HMDB02005 • KEGG: C02989 • Found: 20×
Total abundance
7,214,724

Leucine

Formula: C6H13NO2 • m/z: 133.10591 • RT: 603.562
HMDB: HMDB00687 • KEGG: C00123 • Found: 2×
Total abundance
1,275,405

L-Phenylalanine

Formula: C9H11NO2 • m/z: 164.07143 • RT: 595.0478
HMDB: HMDB00159 • KEGG: C00079 • Found: 6×
Total abundance
1,089,675

N-Acetylserine

Formula: C5H9NO4 • m/z: 148.06085 • RT: 790.658
HMDB: HMDB02931 • Found: 4×
Total abundance
1,054,663

L-Threonine

Formula: C4H9NO3 • m/z: 119.05372 • RT: 771.834
HMDB: HMDB00165 • KEGG: C00186 • Found: 4×
Total abundance
819,817

Sample Timecourse (30 samples)

WPI Dose: 0 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180201_TOFI2_B1_HILIC_046 1 L-Leucine 4,481,760 L-Glutamic Acid 2,579,975 Citrulline 564,894
0 POS 20180201_TOFI2_B1_HILIC_046 1 L-Leucine 4,481,760 L-Glutamic Acid 2,579,975 Citrulline 564,894
30 POS 20180201_TOFI2_B1_HILIC_047 1 L-Leucine 4,929,136 L-Glutamic Acid 2,246,168 Citrulline 570,129
30 POS 20180201_TOFI2_B1_HILIC_047 1 L-Leucine 4,929,136 L-Glutamic Acid 2,246,168 Citrulline 570,129
60 POS 20180201_TOFI2_B1_HILIC_048 1 L-Leucine 4,652,264 L-Glutamic Acid 2,636,618 L-Asparagine 566,353
60 POS 20180201_TOFI2_B1_HILIC_048 1 L-Leucine 4,652,264 L-Glutamic Acid 2,636,618 L-Asparagine 566,353
120 POS 20180201_TOFI2_B1_HILIC_049 1 L-Leucine 4,679,652 L-Glutamic Acid 2,515,228 L-Serine 563,319
120 POS 20180201_TOFI2_B1_HILIC_049 1 L-Leucine 4,679,652 L-Glutamic Acid 2,515,228 L-Serine 563,319
240 POS 20180201_TOFI2_B1_HILIC_050 1 L-Leucine 5,580,631 L-Glutamic Acid 2,399,056 L-Serine 576,597
240 POS 20180201_TOFI2_B1_HILIC_050 1 L-Leucine 5,580,631 L-Glutamic Acid 2,399,056 L-Serine 576,597

WPI Dose: 12.5 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180201_TOFI2_B1_HILIC_051 1 L-Leucine 4,064,965 L-Glutamic Acid 2,679,289 L-Asparagine 634,312
0 POS 20180201_TOFI2_B1_HILIC_051 1 L-Leucine 4,064,965 L-Glutamic Acid 2,679,289 L-Asparagine 634,312
30 POS 20180201_TOFI2_B1_HILIC_052 1 L-Leucine 10,205,731 L-Glutamic Acid 2,970,986 L-Asparagine 991,766
30 POS 20180201_TOFI2_B1_HILIC_052 1 L-Leucine 10,205,731 L-Glutamic Acid 2,970,986 L-Asparagine 991,766
60 POS 20180201_TOFI2_B1_HILIC_053 1 L-Leucine 13,887,319 L-Glutamic Acid 2,473,374 L-Asparagine 915,215
60 POS 20180201_TOFI2_B1_HILIC_053 1 L-Leucine 13,887,319 L-Glutamic Acid 2,473,374 L-Asparagine 915,215
120 POS 20180201_TOFI2_B1_HILIC_054 1 L-Leucine 5,537,500 L-Glutamic Acid 2,387,497 L-Asparagine 552,275
120 POS 20180201_TOFI2_B1_HILIC_054 1 L-Leucine 5,537,500 L-Glutamic Acid 2,387,497 L-Asparagine 552,275
240 POS 20180201_TOFI2_B1_HILIC_055 1 L-Leucine 4,587,255 L-Glutamic Acid 2,599,335 L-Asparagine 598,101
240 POS 20180201_TOFI2_B1_HILIC_055 1 L-Leucine 4,587,255 L-Glutamic Acid 2,599,335 L-Asparagine 598,101

WPI Dose: 50 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180201_TOFI2_B1_HILIC_057 1 L-Leucine 3,546,653 L-Glutamic Acid 2,369,586 Citrulline 628,334
0 POS 20180201_TOFI2_B1_HILIC_057 1 L-Leucine 3,546,653 L-Glutamic Acid 2,369,586 Citrulline 628,334
30 POS 20180201_TOFI2_B1_HILIC_058 1 L-Leucine 12,659,731 L-Glutamic Acid 2,870,906 L-Asparagine 1,194,042
30 POS 20180201_TOFI2_B1_HILIC_058 1 L-Leucine 12,659,731 L-Glutamic Acid 2,870,906 L-Asparagine 1,194,042
60 POS 20180201_TOFI2_B1_HILIC_059 1 L-Leucine 17,425,615 L-Glutamic Acid 2,441,367 L-Asparagine 1,099,975
60 POS 20180201_TOFI2_B1_HILIC_059 1 L-Leucine 17,425,615 L-Glutamic Acid 2,441,367 L-Asparagine 1,099,975
120 POS 20180201_TOFI2_B1_HILIC_060 1 L-Leucine 19,951,626 L-Glutamic Acid 2,440,635 L-Isoleucine 1,274,553
120 POS 20180201_TOFI2_B1_HILIC_060 1 L-Leucine 19,951,626 L-Glutamic Acid 2,440,635 L-Isoleucine 1,274,553
240 POS 20180201_TOFI2_B1_HILIC_061 1 L-Leucine 6,743,276 L-Glutamic Acid 2,558,646 Citrulline 652,361
240 POS 20180201_TOFI2_B1_HILIC_061 1 L-Leucine 6,743,276 L-Glutamic Acid 2,558,646 Citrulline 652,361

All Samples

20180201_TOFI2_B1_HILIC_046 POS

Time: 0 min • Dose: 0 g • Batch: 1
L-Leucine 4,481,760
L-Glutamic Acid 2,579,975
Citrulline 564,894
L-Serine 560,007
L-Asparagine 523,032

20180201_TOFI2_B1_HILIC_046 POS

Time: 0 min • Dose: 0 g • Batch: 1
L-Leucine 4,481,760
L-Glutamic Acid 2,579,975
Citrulline 564,894
L-Serine 560,007
L-Asparagine 523,032

20180201_TOFI2_B1_HILIC_051 POS

Time: 0 min • Dose: 12.5 g • Batch: 1
L-Leucine 4,064,965
L-Glutamic Acid 2,679,289
L-Asparagine 634,312
Citrulline 601,377
L-Serine 597,028

20180201_TOFI2_B1_HILIC_051 POS

Time: 0 min • Dose: 12.5 g • Batch: 1
L-Leucine 4,064,965
L-Glutamic Acid 2,679,289
L-Asparagine 634,312
Citrulline 601,377
L-Serine 597,028

20180201_TOFI2_B1_HILIC_057 POS

Time: 0 min • Dose: 50 g • Batch: 1
L-Leucine 3,546,653
L-Glutamic Acid 2,369,586
Citrulline 628,334
L-Serine 558,492
L-Asparagine 492,242

20180201_TOFI2_B1_HILIC_057 POS

Time: 0 min • Dose: 50 g • Batch: 1
L-Leucine 3,546,653
L-Glutamic Acid 2,369,586
Citrulline 628,334
L-Serine 558,492
L-Asparagine 492,242

20180201_TOFI2_B1_HILIC_047 POS

Time: 30 min • Dose: 0 g • Batch: 1
L-Leucine 4,929,136
L-Glutamic Acid 2,246,168
Citrulline 570,129
L-Serine 527,688
L-Asparagine 514,565

20180201_TOFI2_B1_HILIC_047 POS

Time: 30 min • Dose: 0 g • Batch: 1
L-Leucine 4,929,136
L-Glutamic Acid 2,246,168
Citrulline 570,129
L-Serine 527,688
L-Asparagine 514,565

20180201_TOFI2_B1_HILIC_052 POS

Time: 30 min • Dose: 12.5 g • Batch: 1
L-Leucine 10,205,731
L-Glutamic Acid 2,970,986
L-Asparagine 991,766
L-Tyrosine 823,813
Citrulline 780,815

20180201_TOFI2_B1_HILIC_052 POS

Time: 30 min • Dose: 12.5 g • Batch: 1
L-Leucine 10,205,731
L-Glutamic Acid 2,970,986
L-Asparagine 991,766
L-Tyrosine 823,813
Citrulline 780,815

20180201_TOFI2_B1_HILIC_058 POS

Time: 30 min • Dose: 50 g • Batch: 1
L-Leucine 12,659,731
L-Glutamic Acid 2,870,906
L-Asparagine 1,194,042
L-Tyrosine 917,871
L-Serine 806,120

20180201_TOFI2_B1_HILIC_058 POS

Time: 30 min • Dose: 50 g • Batch: 1
L-Leucine 12,659,731
L-Glutamic Acid 2,870,906
L-Asparagine 1,194,042
L-Tyrosine 917,871
L-Serine 806,120

20180201_TOFI2_B1_HILIC_048 POS

Time: 60 min • Dose: 0 g • Batch: 1
L-Leucine 4,652,264
L-Glutamic Acid 2,636,618
L-Asparagine 566,353
Citrulline 565,610
L-Serine 554,854

20180201_TOFI2_B1_HILIC_048 POS

Time: 60 min • Dose: 0 g • Batch: 1
L-Leucine 4,652,264
L-Glutamic Acid 2,636,618
L-Asparagine 566,353
Citrulline 565,610
L-Serine 554,854

20180201_TOFI2_B1_HILIC_053 POS

Time: 60 min • Dose: 12.5 g • Batch: 1
L-Leucine 13,887,319
L-Glutamic Acid 2,473,374
L-Asparagine 915,215
L-Isoleucine 853,284
Citrulline 849,080

20180201_TOFI2_B1_HILIC_053 POS

Time: 60 min • Dose: 12.5 g • Batch: 1
L-Leucine 13,887,319
L-Glutamic Acid 2,473,374
L-Asparagine 915,215
L-Isoleucine 853,284
Citrulline 849,080

20180201_TOFI2_B1_HILIC_059 POS

Time: 60 min • Dose: 50 g • Batch: 1
L-Leucine 17,425,615
L-Glutamic Acid 2,441,367
L-Asparagine 1,099,975
L-Isoleucine 1,082,095
L-Tyrosine 980,954

20180201_TOFI2_B1_HILIC_059 POS

Time: 60 min • Dose: 50 g • Batch: 1
L-Leucine 17,425,615
L-Glutamic Acid 2,441,367
L-Asparagine 1,099,975
L-Isoleucine 1,082,095
L-Tyrosine 980,954

20180201_TOFI2_B1_HILIC_049 POS

Time: 120 min • Dose: 0 g • Batch: 1
L-Leucine 4,679,652
L-Glutamic Acid 2,515,228
L-Serine 563,319
L-Asparagine 529,310
Citrulline 520,309

20180201_TOFI2_B1_HILIC_049 POS

Time: 120 min • Dose: 0 g • Batch: 1
L-Leucine 4,679,652
L-Glutamic Acid 2,515,228
L-Serine 563,319
L-Asparagine 529,310
Citrulline 520,309

20180201_TOFI2_B1_HILIC_054 POS

Time: 120 min • Dose: 12.5 g • Batch: 1
L-Leucine 5,537,500
L-Glutamic Acid 2,387,497
L-Asparagine 552,275
Citrulline 532,616
Pyridoxamine dihydrochloride 525,620

20180201_TOFI2_B1_HILIC_054 POS

Time: 120 min • Dose: 12.5 g • Batch: 1
L-Leucine 5,537,500
L-Glutamic Acid 2,387,497
L-Asparagine 552,275
Citrulline 532,616
Pyridoxamine dihydrochloride 525,620

20180201_TOFI2_B1_HILIC_060 POS

Time: 120 min • Dose: 50 g • Batch: 1
L-Leucine 19,951,626
L-Glutamic Acid 2,440,635
L-Isoleucine 1,274,553
L-Tyrosine 1,099,151
Citrulline 1,038,295

20180201_TOFI2_B1_HILIC_060 POS

Time: 120 min • Dose: 50 g • Batch: 1
L-Leucine 19,951,626
L-Glutamic Acid 2,440,635
L-Isoleucine 1,274,553
L-Tyrosine 1,099,151
Citrulline 1,038,295

20180201_TOFI2_B1_HILIC_050 POS

Time: 240 min • Dose: 0 g • Batch: 1
L-Leucine 5,580,631
L-Glutamic Acid 2,399,056
L-Serine 576,597
L-Asparagine 573,234
Citrulline 555,334

20180201_TOFI2_B1_HILIC_050 POS

Time: 240 min • Dose: 0 g • Batch: 1
L-Leucine 5,580,631
L-Glutamic Acid 2,399,056
L-Serine 576,597
L-Asparagine 573,234
Citrulline 555,334

20180201_TOFI2_B1_HILIC_055 POS

Time: 240 min • Dose: 12.5 g • Batch: 1
L-Leucine 4,587,255
L-Glutamic Acid 2,599,335
L-Asparagine 598,101
L-Serine 572,225
Citrulline 513,766

20180201_TOFI2_B1_HILIC_055 POS

Time: 240 min • Dose: 12.5 g • Batch: 1
L-Leucine 4,587,255
L-Glutamic Acid 2,599,335
L-Asparagine 598,101
L-Serine 572,225
Citrulline 513,766

20180201_TOFI2_B1_HILIC_061 POS

Time: 240 min • Dose: 50 g • Batch: 1
L-Leucine 6,743,276
L-Glutamic Acid 2,558,646
Citrulline 652,361
L-Serine 502,542
L-Tyrosine 501,583

20180201_TOFI2_B1_HILIC_061 POS

Time: 240 min • Dose: 50 g • Batch: 1
L-Leucine 6,743,276
L-Glutamic Acid 2,558,646
Citrulline 652,361
L-Serine 502,542
L-Tyrosine 501,583
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