Longevity signature by Cell Type

System introduction

Cardiovascular system

The cardiovascular system, also known as the circulatory system, is responsible for transporting blood throughout the body. Its core components are the heart, blood, and blood vessels (arteries, veins, capillaries). The system delivers oxygen and nutrients to tissues, removes carbon dioxide and metabolic wastes, transports hormones, and helps regulate body temperature and pH. It is vital for cellular respiration, immunity, and overall homeostasis.

Source: LACA body-system catalog

Observed descriptive scores for the predefined 15-gene longevity signature in SP121's selected system. Values are read from the published system payload.

SP121 · Cardiovascular system53,554 cells6 cell types

Download summary CSV →Open source analysis →

0.07502Overall mean score

0.07248Overall median

0.1506495th percentile

92.21%Cells with score > 0

MacrophagesHighest observed mean score

Selected system

Cell-type summary

Filter by system or cell type. “Positive” means score greater than zero; it is not a p-value or enrichment call.

Search system or cell type

Minimum cells

Sort by

Rank	Cell type	Cells	Mean score	Positive cells	Maximum	Sampling note

Method & provenance

Dataset contract

Equal-weight species-calibrated score

mean(clip(matrix_value / species_positive_q99, 0, 1))

Each mapped gene is scaled by its 99th percentile among positive cells in the complete source-species H5AD.
The same 15 mapped genes and SP121 species calibration are used for every system.
The score is descriptive relative expression on a 0–1 scale.

Pinned analyzed release

Release: r20260808-v4
Source file: SP121.h5ad
Cell-type key: laca_curated_celltype_v3
Generated: 2026-08-07T17:18:37.185043+00:00

Raw JSON →