⚙ How is this computed? Methods: Correlation Analysis
Longevity · Real single-cell summary

Longevity signature by Cell Type

Endocrine system illustration
sys07 · Endocrine system
System introduction

Endocrine system

The endocrine system is a network of glands and cells that secrete hormones directly into the bloodstream to regulate distant target organs and tissues. Major glands include the pituitary, thyroid, adrenals, pancreas, and gonads. Hormones act as chemical messengers to control vital processes such as metabolism, growth and development, mood, reproduction, and homeostasis. It works in a closely integrated manner with the nervous system to coordinate bodily functions.

Source: LACA body-system catalog

Observed descriptive scores for the predefined 15-gene longevity signature in SP121's selected system. Values are read from the published system payload.

SP121 · Endocrine system119,655 cells12 cell types
0.08088Overall mean score
0.07756Overall median
0.1668595th percentile
92.14%Cells with score > 0
MonocytesHighest observed mean score
Selected system

Cell-type summary

Filter by system or cell type. “Positive” means score greater than zero; it is not a p-value or enrichment call.

RankCell typeCellsMean scorePositive cellsMaximumSampling note
Method & provenance

Dataset contract

Equal-weight species-calibrated score

mean(clip(matrix_value / species_positive_q99, 0, 1))

  • Each mapped gene is scaled by its 99th percentile among positive cells in the complete source-species H5AD.
  • The same 15 mapped genes and SP121 species calibration are used for every system.
  • The score is descriptive relative expression on a 0–1 scale.

Pinned analyzed release

Release: r20260808-v4
Source file: SP121.h5ad
Cell-type key: laca_curated_celltype_v3
Generated: 2026-08-07T17:18:41.105841+00:00