Total Interactions
5,799
Significant ligand-receptor pairs
Analysis Complete
Analysis Results sys09
Published legacy analysis modules for the selected page.
๐ System Level
Cell Communication
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GRN Analysis
โ
Co-expression
โ
Trajectory
Not computed
DEG Analysis
โ
GO / KEGG
Not computed
ToppGene
Not computed
Motif
Not computed
Metabolism
Not computed
Disease
โ
Drug Analysis
Not computed
Full Report
Cell-Cell CommunicationLigand-Receptor Interaction Analysis via CellChat / CellPhoneDB
๐ข
๐ค๏ธ
Signaling Pathways
26
Unique pathways detected
๐ค
Top Sender
Macrophages
Most active signaling cell type
๐ฅ
Top Receiver
CD4+ T cells
Most active receiving cell type
Communication Heatmap
Overall interaction strength between cell types. Rows = sender, columns = receiver.
Communication Network
Network visualization of top 50 cell-cell interactions. Node size = connectivity degree.
Signaling Pathway Activity
Top signaling pathways ranked by total communication score.
๐ Top Ligand-Receptor Interactions
| source | target | ligand | receptor | pathway | ligand_expr | receptor_expr | score |
|---|---|---|---|---|---|---|---|
| Mesothelial cells | Mesothelial cells | TGFB1 | TGFBR1 | TGFb | 0.0037 | 0.0835 | 0.0003 |
| Mesothelial cells | Urothelial cells | TGFB1 | TGFBR1 | TGFb | 0.0037 | 0.1105 | 0.0004 |
| Mesothelial cells | Fibroblasts | TGFB1 | TGFBR1 | TGFb | 0.0037 | 0.1967 | 0.0007 |
| Mesothelial cells | Smooth muscle cells | TGFB1 | TGFBR1 | TGFb | 0.0037 | 0.2113 | 0.0008 |
| Mesothelial cells | Endothelial cells | TGFB1 | TGFBR1 | TGFb | 0.0037 | 0.0931 | 0.0003 |
| Mesothelial cells | Macrophages | TGFB1 | TGFBR1 | TGFb | 0.0037 | 0.0962 | 0.0004 |
| Mesothelial cells | Adipocytes | TGFB1 | TGFBR1 | TGFb | 0.0037 | 0.0777 | 0.0003 |
| Mesothelial cells | Proximal tubule cells | TGFB1 | TGFBR1 | TGFb | 0.0037 | 0.1006 | 0.0004 |
| Mesothelial cells | Thick ascending limb cells | TGFB1 | TGFBR1 | TGFb | 0.0037 | 0.107 | 0.0004 |
| Mesothelial cells | Parietal epithelial cells | TGFB1 | TGFBR1 | TGFb | 0.0037 | 0.1281 | 0.0005 |
| Mesothelial cells | Collecting duct principal cells | TGFB1 | TGFBR1 | TGFb | 0.0037 | 0.1332 | 0.0005 |
| Mesothelial cells | Intercalated cells | TGFB1 | TGFBR1 | TGFb | 0.0037 | 0.0808 | 0.0003 |
Showing top 12 rows ยท Download full table above
Gene Regulatory NetworkTranscription Factor Activity & TF-Target Inference (pySCENIC / DoRothEA)
๐๏ธ
TFs Analyzed
90
Transcription factors profiled
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TF-Target Pairs
342
Significant regulatory relationships
Top Regulatory TFs
RUNX1
84 targets
HNF4A
76 targets
GATA3
68 targets
FOXA1
50 targets
GATA2
39 targets
RUNX2
19 targets
TP53
5 targets
STAT3
1 targets
TF Activity Heatmap
Z-score normalized TF expression across cell populations.
Gene Regulatory Network
Red nodes: TFs. Blue: targets. Green edge: activation. Red edge: repression.
Gene Co-expression NetworkWGCNA-style Module Analysis (hdWGCNA)
๐ฆ
Modules Identified
30
Co-expression gene modules
๐งฌ
Genes Analyzed
2,000
Highly variable genes
Module Dendrogram
Hierarchical clustering of co-expression modules based on topological overlap.
Module-Cell Type Association
Module eigengene activity across cell types.
Differential ExpressionCell Type Marker Genes (Wilcoxon / MAST)
๐
Significant DEGs
1,780
Genes passing adj. p < 0.05 & |log2FC| > 0.5
๐ท๏ธ
Cell Types Compared
18
Cell populations analyzed
Volcano Plot
Log2 fold change vs significance. Red: up-regulated. Blue: down-regulated.
Marker Gene Heatmap
Z-score normalized expression of top marker genes per cell type.
๐ Top Marker Genes
| names | scores | logfoldchanges | pvals | pvals_adj | pct_nz_group | pct_nz_reference | cell_type |
|---|---|---|---|---|---|---|---|
| GYS2 | 14.1745 | 9.6249 | 0 | 0 | 0.6623 | 0.0028 | Adipocytes |
| LGALS12 | 8.8994 | 9.4002 | 0 | 0 | 0.4156 | 0.0014 | Adipocytes |
| KLB | 10.693 | 8.9387 | 0 | 0 | 0.5 | 0.0026 | Adipocytes |
| GRIK3 | 7.2173 | 8.4551 | 0 | 0 | 0.3377 | 0.0017 | Adipocytes |
| TSHR | 16.8891 | 8.4261 | 0 | 0 | 0.7922 | 0.0171 | Adipocytes |
| PLIN1 | 11.5009 | 8.3152 | 0 | 0 | 0.539 | 0.0047 | Adipocytes |
| FABP4 | 12.9978 | 8.2217 | 0 | 0 | 0.6104 | 0.0065 | Adipocytes |
| ADIPOQ | 8.4516 | 8.109 | 0 | 0 | 0.3961 | 0.0029 | Adipocytes |
| PON3 | 7.7461 | 7.7623 | 0 | 0 | 0.3636 | 0.0035 | Adipocytes |
| NDRG4 | 9.1176 | 7.6386 | 0 | 0 | 0.4286 | 0.0046 | Adipocytes |
| MS4A1 | 4.3429 | 9.3452 | 0 | 0.0022 | 0.3333 | 0.0015 | B cells |
| SLAMF6 | 6.592 | 7.9172 | 0 | 0 | 0.5088 | 0.0062 | B cells |
Showing top 12 rows
Disease AssociationDisease Gene Enrichment (scDRS / DisGeNET / OMIM / ToppGene)
๐ฌ
Diseases Tested
15
Disease categories analyzed
โ
Significant Associations
16
Cell type-disease links (adj. p < 0.05)
Top Associated Diseases
Disease Association Heatmap
-Log10(P-value) of disease gene enrichment per cell type.
Top Disease Associations
Dot size: overlap genes. Color: significance.
Full Analysis ReportComprehensive Summary & Downloads
Interactive HTML Report
Complete analysis report with all figures, key findings, and data summaries in a standalone HTML page.
๐ Open ReportDownload All Results
Download all analysis results including CSV data, PNG figures, and JSON summaries as a compressed archive.
๐ฅ Download ZIPShare Results
Use this permanent link to share these analysis results:
analysis.php?SP_ID=SP239&sysID=sys09
๐ Available Result Files
| Analysis | File | Type | Action |
|---|---|---|---|
| Cell Communication | cellchat_heatmap.png | Figure (PNG) | ๐ View |
| Cell Communication | cellchat_network.png | Figure (PNG) | ๐ View |
| Cell Communication | cellchat_pathway_dotplot.png | Figure (PNG) | ๐ View |
| Cell Communication | cellchat_interactions.csv | Data (CSV) | ๐ฅ Download |
| Cell Communication | cellchat_pathway_summary.csv | Data (CSV) | ๐ฅ Download |
| GRN Analysis | grn_tf_heatmap.png | Figure (PNG) | ๐ View |
| GRN Analysis | grn_network.png | Figure (PNG) | ๐ View |
| GRN Analysis | grn_tf_activity.csv | Data (CSV) | ๐ฅ Download |
| GRN Analysis | grn_tf_targets.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_dendrogram.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_module_heatmap.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_modules.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_eigengenes.csv | Data (CSV) | ๐ฅ Download |
| DEG Analysis | deg_volcano.png | Figure (PNG) | ๐ View |
| DEG Analysis | deg_marker_heatmap.png | Figure (PNG) | ๐ View |
| DEG Analysis | deg_top_markers.csv | Data (CSV) | ๐ฅ Download |
| DEG Analysis | deg_significant.csv | Data (CSV) | ๐ฅ Download |
| DEG Analysis | deg_all_results.csv | Data (CSV) | ๐ฅ Download |
| Disease | disease_heatmap.png | Figure (PNG) | ๐ View |
| Disease | disease_dotplot.png | Figure (PNG) | ๐ View |
| Disease | disease_enrichment.csv | Data (CSV) | ๐ฅ Download |
| Report | sys09_analysis_report.html | Report (HTML) | ๐ Open |
| Report | sys09_summary.json | Summary (JSON) | ๐ฅ Download |