Total Interactions
2,197
Significant ligand-receptor pairs
Analysis Complete
Analysis Results sys02tis05
Published legacy analysis modules for the selected page.
๐ Tissue Level
Cell Communication
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GRN Analysis
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Co-expression
โ
Trajectory
Not computed
DEG Analysis
โ
GO / KEGG
Not computed
ToppGene
Not computed
Motif
Not computed
Metabolism
Not computed
Disease
โ
Drug Analysis
Not computed
Full Report
Cell-Cell CommunicationLigand-Receptor Interaction Analysis via CellChat / CellPhoneDB
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๐ค๏ธ
Signaling Pathways
27
Unique pathways detected
๐ค
Top Sender
Macrophages
Most active signaling cell type
๐ฅ
Top Receiver
Adipocytes
Most active receiving cell type
Communication Heatmap
Overall interaction strength between cell types. Rows = sender, columns = receiver.
Communication Network
Network visualization of top 50 cell-cell interactions. Node size = connectivity degree.
Signaling Pathway Activity
Top signaling pathways ranked by total communication score.
๐ Top Ligand-Receptor Interactions
| source | target | ligand | receptor | pathway | ligand_expr | receptor_expr | score |
|---|---|---|---|---|---|---|---|
| B cells | B cells | TGFB1 | TGFBR1 | TGFb | 0.0417 | 0.3055 | 0.0127 |
| B cells | Macrophages | TGFB1 | TGFBR1 | TGFb | 0.0417 | 0.3451 | 0.0144 |
| B cells | Endothelial cells | TGFB1 | TGFBR1 | TGFb | 0.0417 | 0.1737 | 0.0072 |
| B cells | Secretory epithelial cells | TGFB1 | TGFBR1 | TGFb | 0.0417 | 0.142 | 0.0059 |
| B cells | Fibroblasts | TGFB1 | TGFBR1 | TGFb | 0.0417 | 0.1465 | 0.0061 |
| B cells | Adipocytes | TGFB1 | TGFBR1 | TGFb | 0.0417 | 0.3175 | 0.0132 |
| B cells | Dendritic cells | TGFB1 | TGFBR1 | TGFb | 0.0417 | 0.4321 | 0.018 |
| B cells | Smooth muscle cells | TGFB1 | TGFBR1 | TGFb | 0.0417 | 0.0844 | 0.0035 |
| B cells | CD4+ T cells | TGFB1 | TGFBR1 | TGFb | 0.0417 | 0.2167 | 0.009 |
| B cells | DN T cells | TGFB1 | TGFBR1 | TGFb | 0.0417 | 0.2919 | 0.0122 |
| B cells | Plasma B cells | TGFB1 | TGFBR1 | TGFb | 0.0417 | 0.1188 | 0.005 |
| B cells | Cycling T cells | TGFB1 | TGFBR1 | TGFb | 0.0417 | 0.1717 | 0.0072 |
Showing top 12 rows ยท Download full table above
Gene Regulatory NetworkTranscription Factor Activity & TF-Target Inference (pySCENIC / DoRothEA)
๐๏ธ
TFs Analyzed
90
Transcription factors profiled
๐
TF-Target Pairs
72
Significant regulatory relationships
Top Regulatory TFs
LEF1
36 targets
SOX9
12 targets
FOXA1
10 targets
GATA4
3 targets
TCF7
3 targets
GATA1
3 targets
NFKB1
1 targets
CEBPA
1 targets
FOS
1 targets
RUNX2
1 targets
TF Activity Heatmap
Z-score normalized TF expression across cell populations.
Gene Regulatory Network
Red nodes: TFs. Blue: targets. Green edge: activation. Red edge: repression.
Gene Co-expression NetworkWGCNA-style Module Analysis (hdWGCNA)
๐ฆ
Modules Identified
30
Co-expression gene modules
๐งฌ
Genes Analyzed
2,000
Highly variable genes
Module Dendrogram
Hierarchical clustering of co-expression modules based on topological overlap.
Module-Cell Type Association
Module eigengene activity across cell types.
Differential ExpressionCell Type Marker Genes (Wilcoxon / MAST)
๐
Significant DEGs
977
Genes passing adj. p < 0.05 & |log2FC| > 0.5
๐ท๏ธ
Cell Types Compared
11
Cell populations analyzed
Volcano Plot
Log2 fold change vs significance. Red: up-regulated. Blue: down-regulated.
Marker Gene Heatmap
Z-score normalized expression of top marker genes per cell type.
๐ Top Marker Genes
| names | scores | logfoldchanges | pvals | pvals_adj | pct_nz_group | pct_nz_reference | cell_type |
|---|---|---|---|---|---|---|---|
| PRR16 | 19.7794 | 9.0175 | 0 | 0 | 0.9286 | 0.024 | Adipocytes |
| LGALS12 | 9.7024 | 9.0029 | 0 | 0 | 0.4545 | 0.0026 | Adipocytes |
| GYS2 | 18.2208 | 8.8585 | 0 | 0 | 0.8571 | 0.0094 | Adipocytes |
| PLIN4 | 10.9379 | 8.6869 | 0 | 0 | 0.513 | 0.0036 | Adipocytes |
| KLB | 12.7328 | 8.652 | 0 | 0 | 0.5974 | 0.0041 | Adipocytes |
| PTGER3 | 16.8562 | 8.6369 | 0 | 0 | 0.7922 | 0.011 | Adipocytes |
| GHR | 20.2935 | 8.4049 | 0 | 0 | 0.9545 | 0.0646 | Adipocytes |
| GPD1 | 10.6387 | 8.1089 | 0 | 0 | 0.5 | 0.004 | Adipocytes |
| PLIN1 | 12.2843 | 8.0965 | 0 | 0 | 0.5779 | 0.0055 | Adipocytes |
| ADTRP | 9.2575 | 8.0186 | 0 | 0 | 0.4351 | 0.0036 | Adipocytes |
| ARHGAP24 | 30.8116 | 3.9693 | 0 | 0 | 0.6955 | 0.1693 | B cells |
| BANK1 | 23.5858 | 3.5601 | 0 | 0 | 0.5449 | 0.122 | B cells |
Showing top 12 rows
Disease AssociationDisease Gene Enrichment (scDRS / DisGeNET / OMIM / ToppGene)
๐ฌ
Diseases Tested
15
Disease categories analyzed
โ
Significant Associations
11
Cell type-disease links (adj. p < 0.05)
Top Associated Diseases
Disease Association Heatmap
-Log10(P-value) of disease gene enrichment per cell type.
Top Disease Associations
Dot size: overlap genes. Color: significance.
Full Analysis ReportComprehensive Summary & Downloads
Interactive HTML Report
Complete analysis report with all figures, key findings, and data summaries in a standalone HTML page.
๐ Open ReportDownload All Results
Download all analysis results including CSV data, PNG figures, and JSON summaries as a compressed archive.
๐ฅ Download ZIPShare Results
Use this permanent link to share these analysis results:
analysis.php?SP_ID=SP239&tisID=sys02tis05
๐ Available Result Files
| Analysis | File | Type | Action |
|---|---|---|---|
| Cell Communication | cellchat_heatmap.png | Figure (PNG) | ๐ View |
| Cell Communication | cellchat_network.png | Figure (PNG) | ๐ View |
| Cell Communication | cellchat_pathway_dotplot.png | Figure (PNG) | ๐ View |
| Cell Communication | cellchat_interactions.csv | Data (CSV) | ๐ฅ Download |
| Cell Communication | cellchat_pathway_summary.csv | Data (CSV) | ๐ฅ Download |
| GRN Analysis | grn_tf_heatmap.png | Figure (PNG) | ๐ View |
| GRN Analysis | grn_network.png | Figure (PNG) | ๐ View |
| GRN Analysis | grn_tf_activity.csv | Data (CSV) | ๐ฅ Download |
| GRN Analysis | grn_tf_targets.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_dendrogram.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_module_heatmap.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_modules.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_eigengenes.csv | Data (CSV) | ๐ฅ Download |
| DEG Analysis | deg_volcano.png | Figure (PNG) | ๐ View |
| DEG Analysis | deg_marker_heatmap.png | Figure (PNG) | ๐ View |
| DEG Analysis | deg_top_markers.csv | Data (CSV) | ๐ฅ Download |
| DEG Analysis | deg_significant.csv | Data (CSV) | ๐ฅ Download |
| DEG Analysis | deg_all_results.csv | Data (CSV) | ๐ฅ Download |
| Disease | disease_heatmap.png | Figure (PNG) | ๐ View |
| Disease | disease_dotplot.png | Figure (PNG) | ๐ View |
| Disease | disease_enrichment.csv | Data (CSV) | ๐ฅ Download |
| Report | sys02tis05_analysis_report.html | Report (HTML) | ๐ Open |
| Report | sys02tis05_summary.json | Summary (JSON) | ๐ฅ Download |