TFs Analyzed
20
Transcription factors profiled
Exploratory Modules Available
Analysis Results SP460
Published legacy analysis modules for the selected page.
๐ Species Level
No validated Atlas analysis release is published for this page.
Validated exploratory / stratified sample.
Artifact and provenance checks passed for the linked advanced-module package.
These tabs use a deterministic tissue x cell-type stratified sample
(n=3,392,
seed=20260808) and are descriptive cell-level analyses,
not donor-level inference. Cell communication, species-wide trajectory, and age association remain not computed.
Cell Communication
Not computed
TF Associations
Exploratory
Co-expression
Exploratory
Trajectory
Not computed
Marker Ranking
Exploratory
GO / KEGG
Not computed
ToppGene
Not computed
Motif
Not computed
Metabolism
Exploratory
Disease
Exploratory
Drug Analysis
Exploratory
Full Report
Exploratory TF-Target AssociationsPearson associations in the stratified sample; not causal regulatory inference
๐๏ธ
๐
TF-Target Pairs
189
Thresholded Pearson associations
Top TF Association Counts
ATF3
9 associations
EOMES
7 associations
FOS
26 associations
GATA2
6 associations
NFE2L2
12 associations
NKX2-1
13 associations
OTX2
16 associations
SOX11
35 associations
SOX2
10 associations
SPI1
16 associations
TF Activity Heatmap
Z-score normalized TF expression across cell populations.
Exploratory TF-Target Association Network
Pearson TF-target associations in the stratified sample; not a causal regulatory network.
Gene Co-expression NetworkExpression-correlation modules in the stratified sample; descriptive only
๐ฆ
Modules Identified
30
Co-expression gene modules
๐งฌ
Genes Analyzed
2,000
Highly variable genes
Module Dendrogram
Hierarchical clustering of expression correlations in the stratified sample.
Module-Cell Type Association
Module eigengene activity across cell types.
Descriptive Marker RankingCell-type marker ranking in sampled cells; not donor-level differential inference
๐
Ranked Marker Rows
1,146
Cell-level descriptive thresholds; no independent donor replicates
๐ท๏ธ
Cell Types Compared
17
Cell populations analyzed
Marker Ranking Volcano Plot
Cell-level descriptive marker ranking; not donor-level differential inference.
Marker Gene Heatmap
Z-score normalized expression of top marker genes per cell type.
๐ Top Marker Genes
| names | scores | logfoldchanges | pvals | pvals_adj | pct_nz_group | pct_nz_reference | cell_type |
|---|---|---|---|---|---|---|---|
| ITGBL1 | 8.3863 | 7.851 | 0 | 0 | 0.4811 | 0.0043 | Chondrocytes |
| PLA2G4C | 9.1805 | 5.1839 | 0 | 0 | 0.5472 | 0.0307 | Chondrocytes |
| GCH1 | 8.0828 | 4.926 | 0 | 0 | 0.4811 | 0.0213 | Chondrocytes |
| COL1A1 | 15.4587 | 4.9027 | 0 | 0 | 1 | 0.2651 | Chondrocytes |
| NID1 | 14.827 | 4.8186 | 0 | 0 | 0.9057 | 0.1184 | Chondrocytes |
| NXPH4 | 5.1564 | 4.6357 | 0 | 0 | 0.3113 | 0.0192 | Chondrocytes |
| EN1 | 8.1164 | 4.5927 | 0 | 0 | 0.5 | 0.0478 | Chondrocytes |
| COL1A2 | 15.0979 | 4.528 | 0 | 0 | 0.9906 | 0.252 | Chondrocytes |
| SMOC1 | 7.2972 | 4.2414 | 0 | 0 | 0.4434 | 0.0277 | Chondrocytes |
| DCN | 12.9829 | 3.9013 | 0 | 0 | 0.8679 | 0.1692 | Chondrocytes |
| ADGRL4 | 5.066 | 29.8361 | 0 | 0.0001 | 0.3636 | 0 | Endothelium |
| LYVE1 | 4.0073 | 10.9742 | 0.0001 | 0.0068 | 0.2879 | 0.0003 | Endothelium |
Showing top 12 rows
Metabolism AnalysisCurated metabolic gene-set expression scores; descriptive only
๐งช
Pathways Scored
12
Metabolic pathway gene sets tested
โ
Pathways Detected
11
Pathways with genes expressed in data
๐ท๏ธ
Cell Types Analyzed
17
Cell populations scored
Top Metabolic Pathways
Metabolic Pathway Heatmap
Curated metabolic gene-set expression scores across sampled cell types.
Top Metabolic Activities
Top pathway-cell type combinations ranked by activity score. Dot size: genes detected.
Disease AssociationCurated disease-gene set overlap; descriptive only
๐ฌ
Diseases Tested
15
Disease categories analyzed
โ
Significant Associations
4
Cell type-disease links (adj. p < 0.05)
Top Associated Diseases
Disease Association Heatmap
Curated disease-gene set overlap across sampled cell types; descriptive only.
Top Disease Associations
Dot size: overlap genes. Color: significance.
Drug Target AnalysisCurated drug-target expression matching; descriptive only
๐
Drugs Screened
18
Drug compounds evaluated
๐ฏ
Drugs with Targets
4
Drugs with target genes detected in data
๐ท๏ธ
Cell Types Analyzed
17
Cell populations scored
Top Associated Drugs
Drug Target Expression Heatmap
Curated drug-target expression scores across sampled cell types; descriptive only.
Top DrugโCell Type Associations
Dot size: % cells expressing targets. Color: number of targets detected.
๐ DrugโCell Type Scores
| drug | cell_type | category | indication | targets_detected | targets_total | mean_target_expr | pct_cells_expressing | deg_overlap | target_genes |
|---|---|---|---|---|---|---|---|---|---|
| Imatinib | Uncharacterized | Kinase inhibitor | CML / GIST | 1 | 5 | 0 | 0 | 0 | CSF1R |
| Imatinib | Neuron | Kinase inhibitor | CML / GIST | 1 | 5 | 0 | 0 | 0 | CSF1R |
| Imatinib | Progenitors | Kinase inhibitor | CML / GIST | 1 | 5 | 0 | 0 | 0 | CSF1R |
| Imatinib | Mesoderm | Kinase inhibitor | CML / GIST | 1 | 5 | 0 | 0 | 0 | CSF1R |
| Imatinib | Muscle cells | Kinase inhibitor | CML / GIST | 1 | 5 | 0.0113 | 1 | 0 | CSF1R |
| Imatinib | Glia | Kinase inhibitor | CML / GIST | 1 | 5 | 0 | 0 | 0 | CSF1R |
| Imatinib | Somite | Kinase inhibitor | CML / GIST | 1 | 5 | 0 | 0 | 0 | CSF1R |
| Imatinib | Epidermal cells | Kinase inhibitor | CML / GIST | 1 | 5 | 0.0023 | 0.3333 | 0 | CSF1R |
| Imatinib | Erythroid cells | Kinase inhibitor | CML / GIST | 1 | 5 | 0 | 0 | 0 | CSF1R |
| Imatinib | Fibroblasts | Kinase inhibitor | CML / GIST | 1 | 5 | 0.0128 | 0.8475 | 0 | CSF1R |
| Imatinib | Retina | Kinase inhibitor | CML / GIST | 1 | 5 | 0 | 0 | 0 | CSF1R |
| Imatinib | Chondrocytes | Kinase inhibitor | CML / GIST | 1 | 5 | 0 | 0 | 0 | CSF1R |
Showing top 12 rows ยท Download full table above
Exploratory Analysis FilesValidated module artifacts and individual downloads
Exploratory Result Files
Use the validated per-module links below. The general Atlas ZIP endpoint is not presented as containing this linked exploratory package.
Share Results
Use this permanent link to share these analysis results:
analysis.php?SP_ID=SP460
๐ Available Result Files
| Analysis | File | Type | Action |
|---|---|---|---|
| TF Associations | grn_tf_heatmap.png | Figure (PNG) | ๐ View |
| TF Associations | grn_network.png | Figure (PNG) | ๐ View |
| TF Associations | grn_tf_activity.csv | Data (CSV) | ๐ฅ Download |
| TF Associations | grn_tf_targets.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_dendrogram.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_module_heatmap.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_modules.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_eigengenes.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_volcano.png | Figure (PNG) | ๐ View |
| Marker Ranking | deg_marker_heatmap.png | Figure (PNG) | ๐ View |
| Marker Ranking | deg_top_markers.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_significant.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_all_results.csv | Data (CSV) | ๐ฅ Download |
| Metabolism | metabolism_heatmap.png | Figure (PNG) | ๐ View |
| Metabolism | metabolism_dotplot.png | Figure (PNG) | ๐ View |
| Metabolism | metabolism_scores.csv | Data (CSV) | ๐ฅ Download |
| Disease | disease_heatmap.png | Figure (PNG) | ๐ View |
| Disease | disease_dotplot.png | Figure (PNG) | ๐ View |
| Disease | disease_enrichment.csv | Data (CSV) | ๐ฅ Download |
| Drug Analysis | drug_heatmap.png | Figure (PNG) | ๐ View |
| Drug Analysis | drug_dotplot.png | Figure (PNG) | ๐ View |
| Drug Analysis | drug_scores.csv | Data (CSV) | ๐ฅ Download |
| Report | SP460_summary.json | Summary (JSON) | ๐ฅ Download |