DZ4230

MTBLS5568 • Plasma LC-MS metabolomics • Prediabetes whey-protein intervention

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Female Sex
32 yr Age
30.5 BMI
3.7% MRI Pancreas Fat
30 Total Samples (30 POS + 0 NEG)
5 Timepoints: 0, 30, 60, 120, 240 min

Top 15 Metabolite Features (Across All Samples)

L-Leucine

Formula: C6H13NO2 • m/z: 130.0869 • RT: 599.4486
HMDB: HMDB00687 • KEGG: C00123 • Found: 30×
Total abundance
167,347,871

L-Glutamic Acid

Formula: C5H9NO4 • m/z: 146.04542 • RT: 796.2
HMDB: HMDB00148 • KEGG: C00025 • Found: 30×
Total abundance
44,073,501

L-Tyrosine

Formula: C9H11NO3 • m/z: 180.06659 • RT: 700.038
HMDB: HMDB00158 • KEGG: C00082 • Found: 30×
Total abundance
14,197,036

Methionine sulfoxide

Formula: C5H11NO3S • m/z: 164.03856 • RT: 769.768
HMDB: HMDB02005 • KEGG: C02989 • Found: 30×
Total abundance
11,601,858

Citrulline

Formula: C6H13N3O3 • m/z: 174.08819 • RT: 834.04
HMDB: HMDB00904 • KEGG: C00327 • Found: 30×
Total abundance
11,415,962

L-Serine

Formula: C3H7NO3 • m/z: 104.03466 • RT: 826.138
HMDB: HMDB00187 • KEGG: C00065 • Found: 28×
Total abundance
11,340,865

N-Acetylserine

Formula: C5H9NO4 • m/z: 148.06085 • RT: 790.658
HMDB: HMDB02931 • Found: 28×
Total abundance
11,297,543

L-Isoleucine

Formula: C6H13NO2 • m/z: 133.10592 • RT: 589.6156
HMDB: HMDB00172 • KEGG: C00407 • Found: 24×
Total abundance
9,442,326

Pyridoxamine dihydrochloride

Formula: C8H14Cl2N2O2 • m/z: 133.08047 • RT: 741.336 • Found: 26×
Total abundance
8,128,961

L-Asparagine

Formula: C4H8N2O3 • m/z: 131.04572 • RT: 821.266
HMDB: HMDB00168 • KEGG: C00152 • Found: 24×
Total abundance
6,706,709

L-Methionine

Formula: C5H11NO2S • m/z: 148.04348 • RT: 640.282
HMDB: HMDB00696 • KEGG: C00073 • Found: 14×
Total abundance
4,762,713

L-2-Aminoadipic acid

Formula: C6H11NO4 • m/z: 162.07635 • RT: 756.777
HMDB: HMDB00510 • KEGG: C00956 • Found: 4×
Total abundance
1,498,596

Leucine

Formula: C6H13NO2 • m/z: 133.10591 • RT: 603.562
HMDB: HMDB00687 • KEGG: C00123 • Found: 2×
Total abundance
1,044,116

Sample Timecourse (30 samples)

WPI Dose: 50 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180220_TOFI2_B4_HILIC_046 4 L-Leucine 3,247,086 L-Glutamic Acid 1,396,241 L-Tyrosine 440,351
0 POS 20180220_TOFI2_B4_HILIC_046 4 L-Leucine 3,247,086 L-Glutamic Acid 1,396,241 L-Tyrosine 440,351
30 POS 20180220_TOFI2_B4_HILIC_047 4 L-Leucine 8,423,622 L-Glutamic Acid 1,656,288 L-Tyrosine 726,398
30 POS 20180220_TOFI2_B4_HILIC_047 4 L-Leucine 8,423,622 L-Glutamic Acid 1,656,288 L-Tyrosine 726,398
60 POS 20180220_TOFI2_B4_HILIC_048 4 L-Leucine 9,091,743 L-Glutamic Acid 1,534,839 L-Tyrosine 771,012
60 POS 20180220_TOFI2_B4_HILIC_048 4 L-Leucine 9,091,743 L-Glutamic Acid 1,534,839 L-Tyrosine 771,012
120 POS 20180220_TOFI2_B4_HILIC_049 4 L-Leucine 14,513,619 L-Glutamic Acid 1,630,228 N-Acetylserine 1,154,940
120 POS 20180220_TOFI2_B4_HILIC_049 4 L-Leucine 14,513,619 L-Glutamic Acid 1,630,228 N-Acetylserine 1,154,940
240 POS 20180220_TOFI2_B4_HILIC_050 4 L-Leucine 6,490,589 L-Glutamic Acid 1,375,139 L-Tyrosine 484,014
240 POS 20180220_TOFI2_B4_HILIC_050 4 L-Leucine 6,490,589 L-Glutamic Acid 1,375,139 L-Tyrosine 484,014

WPI Dose: 0 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180220_TOFI2_B4_HILIC_051 4 L-Leucine 3,390,924 L-Glutamic Acid 1,467,715 L-Serine 382,221
0 POS 20180220_TOFI2_B4_HILIC_051 4 L-Leucine 3,390,924 L-Glutamic Acid 1,467,715 L-Serine 382,221
30 POS 20180220_TOFI2_B4_HILIC_052 4 L-Leucine 3,513,362 L-Glutamic Acid 1,333,568 L-Serine 366,530
30 POS 20180220_TOFI2_B4_HILIC_052 4 L-Leucine 3,513,362 L-Glutamic Acid 1,333,568 L-Serine 366,530
60 POS 20180220_TOFI2_B4_HILIC_053 4 L-Leucine 3,001,800 L-Glutamic Acid 1,339,898 L-Serine 410,724
60 POS 20180220_TOFI2_B4_HILIC_053 4 L-Leucine 3,001,800 L-Glutamic Acid 1,339,898 L-Serine 410,724
120 POS 20180220_TOFI2_B4_HILIC_054 4 L-Leucine 3,841,317 L-Glutamic Acid 1,445,216 L-Serine 420,742
120 POS 20180220_TOFI2_B4_HILIC_054 4 L-Leucine 3,841,317 L-Glutamic Acid 1,445,216 L-Serine 420,742
240 POS 20180220_TOFI2_B4_HILIC_055 4 L-Leucine 3,345,807 L-Glutamic Acid 1,495,685 L-Serine 430,185
240 POS 20180220_TOFI2_B4_HILIC_055 4 L-Leucine 3,345,807 L-Glutamic Acid 1,495,685 L-Serine 430,185

WPI Dose: 12.5 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180220_TOFI2_B4_HILIC_057 4 L-Leucine 2,882,303 L-Glutamic Acid 1,411,415 Methionine sulfoxide 412,162
0 POS 20180220_TOFI2_B4_HILIC_057 4 L-Leucine 2,882,303 L-Glutamic Acid 1,411,415 Methionine sulfoxide 412,162
30 POS 20180220_TOFI2_B4_HILIC_058 4 L-Leucine 6,635,568 L-Glutamic Acid 1,473,613 L-Tyrosine 529,931
30 POS 20180220_TOFI2_B4_HILIC_058 4 L-Leucine 6,635,568 L-Glutamic Acid 1,473,613 L-Tyrosine 529,931
60 POS 20180220_TOFI2_B4_HILIC_059 4 L-Leucine 6,639,793 L-Glutamic Acid 1,465,985 L-Isoleucine 636,637
60 POS 20180220_TOFI2_B4_HILIC_059 4 L-Leucine 6,639,793 L-Glutamic Acid 1,465,985 L-Isoleucine 636,637
120 POS 20180220_TOFI2_B4_HILIC_060 4 L-Leucine 5,143,301 L-Glutamic Acid 1,536,908 L-Tyrosine 435,622
120 POS 20180220_TOFI2_B4_HILIC_060 4 L-Leucine 5,143,301 L-Glutamic Acid 1,536,908 L-Tyrosine 435,622
240 POS 20180220_TOFI2_B4_HILIC_061 4 L-Leucine 3,513,101 L-Glutamic Acid 1,474,014 L-Serine 375,212
240 POS 20180220_TOFI2_B4_HILIC_061 4 L-Leucine 3,513,101 L-Glutamic Acid 1,474,014 L-Serine 375,212

All Samples

20180220_TOFI2_B4_HILIC_046 POS

Time: 0 min • Dose: 50 g • Batch: 4
L-Leucine 3,247,086
L-Glutamic Acid 1,396,241
L-Tyrosine 440,351
Methionine sulfoxide 433,904
L-Serine 417,311

20180220_TOFI2_B4_HILIC_046 POS

Time: 0 min • Dose: 50 g • Batch: 4
L-Leucine 3,247,086
L-Glutamic Acid 1,396,241
L-Tyrosine 440,351
Methionine sulfoxide 433,904
L-Serine 417,311

20180220_TOFI2_B4_HILIC_051 POS

Time: 0 min • Dose: 0 g • Batch: 4
L-Leucine 3,390,924
L-Glutamic Acid 1,467,715
L-Serine 382,221
L-Tyrosine 319,461
N-Acetylserine 308,435

20180220_TOFI2_B4_HILIC_051 POS

Time: 0 min • Dose: 0 g • Batch: 4
L-Leucine 3,390,924
L-Glutamic Acid 1,467,715
L-Serine 382,221
L-Tyrosine 319,461
N-Acetylserine 308,435

20180220_TOFI2_B4_HILIC_057 POS

Time: 0 min • Dose: 12.5 g • Batch: 4
L-Leucine 2,882,303
L-Glutamic Acid 1,411,415
Methionine sulfoxide 412,162
L-Serine 374,507
N-Acetylserine 347,987

20180220_TOFI2_B4_HILIC_057 POS

Time: 0 min • Dose: 12.5 g • Batch: 4
L-Leucine 2,882,303
L-Glutamic Acid 1,411,415
Methionine sulfoxide 412,162
L-Serine 374,507
N-Acetylserine 347,987

20180220_TOFI2_B4_HILIC_047 POS

Time: 30 min • Dose: 50 g • Batch: 4
L-Leucine 8,423,622
L-Glutamic Acid 1,656,288
L-Tyrosine 726,398
N-Acetylserine 641,594
Methionine sulfoxide 543,318

20180220_TOFI2_B4_HILIC_047 POS

Time: 30 min • Dose: 50 g • Batch: 4
L-Leucine 8,423,622
L-Glutamic Acid 1,656,288
L-Tyrosine 726,398
N-Acetylserine 641,594
Methionine sulfoxide 543,318

20180220_TOFI2_B4_HILIC_052 POS

Time: 30 min • Dose: 0 g • Batch: 4
L-Leucine 3,513,362
L-Glutamic Acid 1,333,568
L-Serine 366,530
L-Tyrosine 311,320
Pyridoxamine dihydrochloride 294,839

20180220_TOFI2_B4_HILIC_052 POS

Time: 30 min • Dose: 0 g • Batch: 4
L-Leucine 3,513,362
L-Glutamic Acid 1,333,568
L-Serine 366,530
L-Tyrosine 311,320
Pyridoxamine dihydrochloride 294,839

20180220_TOFI2_B4_HILIC_058 POS

Time: 30 min • Dose: 12.5 g • Batch: 4
L-Leucine 6,635,568
L-Glutamic Acid 1,473,613
L-Tyrosine 529,931
Methionine sulfoxide 432,645
L-Serine 417,602

20180220_TOFI2_B4_HILIC_058 POS

Time: 30 min • Dose: 12.5 g • Batch: 4
L-Leucine 6,635,568
L-Glutamic Acid 1,473,613
L-Tyrosine 529,931
Methionine sulfoxide 432,645
L-Serine 417,602

20180220_TOFI2_B4_HILIC_048 POS

Time: 60 min • Dose: 50 g • Batch: 4
L-Leucine 9,091,743
L-Glutamic Acid 1,534,839
L-Tyrosine 771,012
Methionine sulfoxide 608,579
L-Isoleucine 567,225

20180220_TOFI2_B4_HILIC_048 POS

Time: 60 min • Dose: 50 g • Batch: 4
L-Leucine 9,091,743
L-Glutamic Acid 1,534,839
L-Tyrosine 771,012
Methionine sulfoxide 608,579
L-Isoleucine 567,225

20180220_TOFI2_B4_HILIC_053 POS

Time: 60 min • Dose: 0 g • Batch: 4
L-Leucine 3,001,800
L-Glutamic Acid 1,339,898
L-Serine 410,724
L-Tyrosine 321,068
Citrulline 294,565

20180220_TOFI2_B4_HILIC_053 POS

Time: 60 min • Dose: 0 g • Batch: 4
L-Leucine 3,001,800
L-Glutamic Acid 1,339,898
L-Serine 410,724
L-Tyrosine 321,068
Citrulline 294,565

20180220_TOFI2_B4_HILIC_059 POS

Time: 60 min • Dose: 12.5 g • Batch: 4
L-Leucine 6,639,793
L-Glutamic Acid 1,465,985
L-Isoleucine 636,637
L-Tyrosine 491,947
Methionine sulfoxide 452,032

20180220_TOFI2_B4_HILIC_059 POS

Time: 60 min • Dose: 12.5 g • Batch: 4
L-Leucine 6,639,793
L-Glutamic Acid 1,465,985
L-Isoleucine 636,637
L-Tyrosine 491,947
Methionine sulfoxide 452,032

20180220_TOFI2_B4_HILIC_049 POS

Time: 120 min • Dose: 50 g • Batch: 4
L-Leucine 14,513,619
L-Glutamic Acid 1,630,228
N-Acetylserine 1,154,940
Citrulline 985,444
L-Tyrosine 976,820

20180220_TOFI2_B4_HILIC_049 POS

Time: 120 min • Dose: 50 g • Batch: 4
L-Leucine 14,513,619
L-Glutamic Acid 1,630,228
N-Acetylserine 1,154,940
Citrulline 985,444
L-Tyrosine 976,820

20180220_TOFI2_B4_HILIC_054 POS

Time: 120 min • Dose: 0 g • Batch: 4
L-Leucine 3,841,317
L-Glutamic Acid 1,445,216
L-Serine 420,742
N-Acetylserine 387,450
Methionine sulfoxide 312,511

20180220_TOFI2_B4_HILIC_054 POS

Time: 120 min • Dose: 0 g • Batch: 4
L-Leucine 3,841,317
L-Glutamic Acid 1,445,216
L-Serine 420,742
N-Acetylserine 387,450
Methionine sulfoxide 312,511

20180220_TOFI2_B4_HILIC_060 POS

Time: 120 min • Dose: 12.5 g • Batch: 4
L-Leucine 5,143,301
L-Glutamic Acid 1,536,908
L-Tyrosine 435,622
Citrulline 393,165
L-Serine 390,778

20180220_TOFI2_B4_HILIC_060 POS

Time: 120 min • Dose: 12.5 g • Batch: 4
L-Leucine 5,143,301
L-Glutamic Acid 1,536,908
L-Tyrosine 435,622
Citrulline 393,165
L-Serine 390,778

20180220_TOFI2_B4_HILIC_050 POS

Time: 240 min • Dose: 50 g • Batch: 4
L-Leucine 6,490,589
L-Glutamic Acid 1,375,139
L-Tyrosine 484,014
Citrulline 389,923
L-Isoleucine 377,040

20180220_TOFI2_B4_HILIC_050 POS

Time: 240 min • Dose: 50 g • Batch: 4
L-Leucine 6,490,589
L-Glutamic Acid 1,375,139
L-Tyrosine 484,014
Citrulline 389,923
L-Isoleucine 377,040

20180220_TOFI2_B4_HILIC_055 POS

Time: 240 min • Dose: 0 g • Batch: 4
L-Leucine 3,345,807
L-Glutamic Acid 1,495,685
L-Serine 430,185
N-Acetylserine 299,068
L-Tyrosine 298,448

20180220_TOFI2_B4_HILIC_055 POS

Time: 240 min • Dose: 0 g • Batch: 4
L-Leucine 3,345,807
L-Glutamic Acid 1,495,685
L-Serine 430,185
N-Acetylserine 299,068
L-Tyrosine 298,448

20180220_TOFI2_B4_HILIC_061 POS

Time: 240 min • Dose: 12.5 g • Batch: 4
L-Leucine 3,513,101
L-Glutamic Acid 1,474,014
L-Serine 375,212
L-Tyrosine 342,400
Pyridoxamine dihydrochloride 289,999

20180220_TOFI2_B4_HILIC_061 POS

Time: 240 min • Dose: 12.5 g • Batch: 4
L-Leucine 3,513,101
L-Glutamic Acid 1,474,014
L-Serine 375,212
L-Tyrosine 342,400
Pyridoxamine dihydrochloride 289,999
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