JG4222

MTBLS5568 • Plasma LC-MS metabolomics • Prediabetes whey-protein intervention

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Female Sex
31 yr Age
26 BMI
4.6% MRI Pancreas Fat
30 Total Samples (30 POS + 0 NEG)
5 Timepoints: 0, 30, 60, 120, 240 min

Top 15 Metabolite Features (Across All Samples)

L-Leucine

Formula: C6H13NO2 • m/z: 130.0869 • RT: 599.4486
HMDB: HMDB00687 • KEGG: C00123 • Found: 30×
Total abundance
142,062,427

L-Glutamic Acid

Formula: C5H9NO4 • m/z: 146.04542 • RT: 796.2
HMDB: HMDB00148 • KEGG: C00025 • Found: 30×
Total abundance
42,006,535

Pyridoxamine dihydrochloride

Formula: C8H14Cl2N2O2 • m/z: 133.08047 • RT: 741.336 • Found: 28×
Total abundance
10,036,464

L-Serine

Formula: C3H7NO3 • m/z: 104.03466 • RT: 826.138
HMDB: HMDB00187 • KEGG: C00065 • Found: 30×
Total abundance
9,841,189

L-Tyrosine

Formula: C9H11NO3 • m/z: 180.06659 • RT: 700.038
HMDB: HMDB00158 • KEGG: C00082 • Found: 30×
Total abundance
9,439,209

Citrulline

Formula: C6H13N3O3 • m/z: 174.08819 • RT: 834.04
HMDB: HMDB00904 • KEGG: C00327 • Found: 30×
Total abundance
8,965,784

L-Isoleucine

Formula: C6H13NO2 • m/z: 133.10592 • RT: 589.6156
HMDB: HMDB00172 • KEGG: C00407 • Found: 30×
Total abundance
8,621,200

L-Asparagine

Formula: C4H8N2O3 • m/z: 131.04572 • RT: 821.266
HMDB: HMDB00168 • KEGG: C00152 • Found: 30×
Total abundance
8,328,981

L-Methionine

Formula: C5H11NO2S • m/z: 148.04348 • RT: 640.282
HMDB: HMDB00696 • KEGG: C00073 • Found: 28×
Total abundance
7,156,172

N-Acetylserine

Formula: C5H9NO4 • m/z: 148.06085 • RT: 790.658
HMDB: HMDB02931 • Found: 20×
Total abundance
2,906,803

Leucine

Formula: C6H13NO2 • m/z: 133.10591 • RT: 603.562
HMDB: HMDB00687 • KEGG: C00123 • Found: 10×
Total abundance
2,424,756

Glycine

Formula: C2H5NO2 • m/z: 76.03997 • RT: 800.582
HMDB: HMDB00123 • KEGG: C00037 • Found: 4×
Total abundance
479,519

Sample Timecourse (30 samples)

WPI Dose: 50 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180212_TOFI2_B3_HILIC_013 3 L-Leucine 2,408,117 L-Glutamic Acid 1,353,511 L-Serine 320,102
0 POS 20180212_TOFI2_B3_HILIC_013 3 L-Leucine 2,408,117 L-Glutamic Acid 1,353,511 L-Serine 320,102
30 POS 20180212_TOFI2_B3_HILIC_014 3 L-Leucine 8,960,760 L-Glutamic Acid 1,457,116 L-Isoleucine 546,503
30 POS 20180212_TOFI2_B3_HILIC_014 3 L-Leucine 8,960,760 L-Glutamic Acid 1,457,116 L-Isoleucine 546,503
60 POS 20180212_TOFI2_B3_HILIC_015 3 L-Leucine 9,647,639 L-Glutamic Acid 1,557,215 L-Isoleucine 610,411
60 POS 20180212_TOFI2_B3_HILIC_015 3 L-Leucine 9,647,639 L-Glutamic Acid 1,557,215 L-Isoleucine 610,411
120 POS 20180212_TOFI2_B3_HILIC_016 3 L-Leucine 10,491,388 L-Glutamic Acid 1,485,280 L-Isoleucine 654,759
120 POS 20180212_TOFI2_B3_HILIC_016 3 L-Leucine 10,491,388 L-Glutamic Acid 1,485,280 L-Isoleucine 654,759
240 POS 20180212_TOFI2_B3_HILIC_017 3 L-Leucine 5,803,048 L-Glutamic Acid 1,389,950 Citrulline 410,874
240 POS 20180212_TOFI2_B3_HILIC_017 3 L-Leucine 5,803,048 L-Glutamic Acid 1,389,950 Citrulline 410,874

WPI Dose: 0 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180212_TOFI2_B3_HILIC_018 3 L-Leucine 3,087,048 L-Glutamic Acid 1,444,713 Pyridoxamine dihydrochloride 377,136
0 POS 20180212_TOFI2_B3_HILIC_018 3 L-Leucine 3,087,048 L-Glutamic Acid 1,444,713 Pyridoxamine dihydrochloride 377,136
30 POS 20180212_TOFI2_B3_HILIC_019 3 L-Leucine 2,405,639 L-Glutamic Acid 1,498,378 L-Serine 325,705
30 POS 20180212_TOFI2_B3_HILIC_019 3 L-Leucine 2,405,639 L-Glutamic Acid 1,498,378 L-Serine 325,705
60 POS 20180212_TOFI2_B3_HILIC_020 3 L-Leucine 2,384,640 L-Glutamic Acid 1,372,423 Pyridoxamine dihydrochloride 354,665
60 POS 20180212_TOFI2_B3_HILIC_020 3 L-Leucine 2,384,640 L-Glutamic Acid 1,372,423 Pyridoxamine dihydrochloride 354,665
120 POS 20180212_TOFI2_B3_HILIC_021 3 L-Leucine 2,440,992 L-Glutamic Acid 1,337,209 Pyridoxamine dihydrochloride 313,294
120 POS 20180212_TOFI2_B3_HILIC_021 3 L-Leucine 2,440,992 L-Glutamic Acid 1,337,209 Pyridoxamine dihydrochloride 313,294
240 POS 20180212_TOFI2_B3_HILIC_022 3 L-Leucine 2,612,415 L-Glutamic Acid 1,350,930 Pyridoxamine dihydrochloride 325,231
240 POS 20180212_TOFI2_B3_HILIC_022 3 L-Leucine 2,612,415 L-Glutamic Acid 1,350,930 Pyridoxamine dihydrochloride 325,231

WPI Dose: 12.5 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180212_TOFI2_B3_HILIC_024 3 L-Leucine 2,654,442 L-Glutamic Acid 1,357,149 L-Serine 323,708
0 POS 20180212_TOFI2_B3_HILIC_024 3 L-Leucine 2,654,442 L-Glutamic Acid 1,357,149 L-Serine 323,708
30 POS 20180212_TOFI2_B3_HILIC_025 3 L-Leucine 6,128,902 L-Glutamic Acid 1,453,492 Pyridoxamine dihydrochloride 413,578
30 POS 20180212_TOFI2_B3_HILIC_025 3 L-Leucine 6,128,902 L-Glutamic Acid 1,453,492 Pyridoxamine dihydrochloride 413,578
60 POS 20180212_TOFI2_B3_HILIC_026 3 L-Leucine 5,160,830 L-Glutamic Acid 1,312,319 Pyridoxamine dihydrochloride 379,072
60 POS 20180212_TOFI2_B3_HILIC_026 3 L-Leucine 5,160,830 L-Glutamic Acid 1,312,319 Pyridoxamine dihydrochloride 379,072
120 POS 20180212_TOFI2_B3_HILIC_027 3 L-Leucine 3,650,004 L-Glutamic Acid 1,360,041 Pyridoxamine dihydrochloride 296,209
120 POS 20180212_TOFI2_B3_HILIC_027 3 L-Leucine 3,650,004 L-Glutamic Acid 1,360,041 Pyridoxamine dihydrochloride 296,209
240 POS 20180212_TOFI2_B3_HILIC_028 3 L-Leucine 3,195,350 L-Glutamic Acid 1,273,542 Pyridoxamine dihydrochloride 335,693
240 POS 20180212_TOFI2_B3_HILIC_028 3 L-Leucine 3,195,350 L-Glutamic Acid 1,273,542 Pyridoxamine dihydrochloride 335,693

All Samples

20180212_TOFI2_B3_HILIC_013 POS

Time: 0 min • Dose: 50 g • Batch: 3
L-Leucine 2,408,117
L-Glutamic Acid 1,353,511
L-Serine 320,102
Pyridoxamine dihydrochloride 315,434
Citrulline 288,499

20180212_TOFI2_B3_HILIC_013 POS

Time: 0 min • Dose: 50 g • Batch: 3
L-Leucine 2,408,117
L-Glutamic Acid 1,353,511
L-Serine 320,102
Pyridoxamine dihydrochloride 315,434
Citrulline 288,499

20180212_TOFI2_B3_HILIC_018 POS

Time: 0 min • Dose: 0 g • Batch: 3
L-Leucine 3,087,048
L-Glutamic Acid 1,444,713
Pyridoxamine dihydrochloride 377,136
L-Serine 334,836
Citrulline 248,891

20180212_TOFI2_B3_HILIC_018 POS

Time: 0 min • Dose: 0 g • Batch: 3
L-Leucine 3,087,048
L-Glutamic Acid 1,444,713
Pyridoxamine dihydrochloride 377,136
L-Serine 334,836
Citrulline 248,891

20180212_TOFI2_B3_HILIC_024 POS

Time: 0 min • Dose: 12.5 g • Batch: 3
L-Leucine 2,654,442
L-Glutamic Acid 1,357,149
L-Serine 323,708
Pyridoxamine dihydrochloride 309,220
Citrulline 258,054

20180212_TOFI2_B3_HILIC_024 POS

Time: 0 min • Dose: 12.5 g • Batch: 3
L-Leucine 2,654,442
L-Glutamic Acid 1,357,149
L-Serine 323,708
Pyridoxamine dihydrochloride 309,220
Citrulline 258,054

20180212_TOFI2_B3_HILIC_014 POS

Time: 30 min • Dose: 50 g • Batch: 3
L-Leucine 8,960,760
L-Glutamic Acid 1,457,116
L-Isoleucine 546,503
L-Tyrosine 464,695
Pyridoxamine dihydrochloride 460,916

20180212_TOFI2_B3_HILIC_014 POS

Time: 30 min • Dose: 50 g • Batch: 3
L-Leucine 8,960,760
L-Glutamic Acid 1,457,116
L-Isoleucine 546,503
L-Tyrosine 464,695
Pyridoxamine dihydrochloride 460,916

20180212_TOFI2_B3_HILIC_019 POS

Time: 30 min • Dose: 0 g • Batch: 3
L-Leucine 2,405,639
L-Glutamic Acid 1,498,378
L-Serine 325,705
Citrulline 244,226
L-Asparagine 223,444

20180212_TOFI2_B3_HILIC_019 POS

Time: 30 min • Dose: 0 g • Batch: 3
L-Leucine 2,405,639
L-Glutamic Acid 1,498,378
L-Serine 325,705
Citrulline 244,226
L-Asparagine 223,444

20180212_TOFI2_B3_HILIC_025 POS

Time: 30 min • Dose: 12.5 g • Batch: 3
L-Leucine 6,128,902
L-Glutamic Acid 1,453,492
Pyridoxamine dihydrochloride 413,578
L-Tyrosine 371,240
L-Serine 368,048

20180212_TOFI2_B3_HILIC_025 POS

Time: 30 min • Dose: 12.5 g • Batch: 3
L-Leucine 6,128,902
L-Glutamic Acid 1,453,492
Pyridoxamine dihydrochloride 413,578
L-Tyrosine 371,240
L-Serine 368,048

20180212_TOFI2_B3_HILIC_015 POS

Time: 60 min • Dose: 50 g • Batch: 3
L-Leucine 9,647,639
L-Glutamic Acid 1,557,215
L-Isoleucine 610,411
L-Tyrosine 592,834
L-Methionine 474,476

20180212_TOFI2_B3_HILIC_015 POS

Time: 60 min • Dose: 50 g • Batch: 3
L-Leucine 9,647,639
L-Glutamic Acid 1,557,215
L-Isoleucine 610,411
L-Tyrosine 592,834
L-Methionine 474,476

20180212_TOFI2_B3_HILIC_020 POS

Time: 60 min • Dose: 0 g • Batch: 3
L-Leucine 2,384,640
L-Glutamic Acid 1,372,423
Pyridoxamine dihydrochloride 354,665
L-Serine 306,867
L-Asparagine 214,289

20180212_TOFI2_B3_HILIC_020 POS

Time: 60 min • Dose: 0 g • Batch: 3
L-Leucine 2,384,640
L-Glutamic Acid 1,372,423
Pyridoxamine dihydrochloride 354,665
L-Serine 306,867
L-Asparagine 214,289

20180212_TOFI2_B3_HILIC_026 POS

Time: 60 min • Dose: 12.5 g • Batch: 3
L-Leucine 5,160,830
L-Glutamic Acid 1,312,319
Pyridoxamine dihydrochloride 379,072
Citrulline 363,192
L-Tyrosine 318,571

20180212_TOFI2_B3_HILIC_026 POS

Time: 60 min • Dose: 12.5 g • Batch: 3
L-Leucine 5,160,830
L-Glutamic Acid 1,312,319
Pyridoxamine dihydrochloride 379,072
Citrulline 363,192
L-Tyrosine 318,571

20180212_TOFI2_B3_HILIC_016 POS

Time: 120 min • Dose: 50 g • Batch: 3
L-Leucine 10,491,388
L-Glutamic Acid 1,485,280
L-Isoleucine 654,759
L-Tyrosine 645,032
Citrulline 462,314

20180212_TOFI2_B3_HILIC_016 POS

Time: 120 min • Dose: 50 g • Batch: 3
L-Leucine 10,491,388
L-Glutamic Acid 1,485,280
L-Isoleucine 654,759
L-Tyrosine 645,032
Citrulline 462,314

20180212_TOFI2_B3_HILIC_021 POS

Time: 120 min • Dose: 0 g • Batch: 3
L-Leucine 2,440,992
L-Glutamic Acid 1,337,209
Pyridoxamine dihydrochloride 313,294
L-Serine 310,178
L-Asparagine 224,375

20180212_TOFI2_B3_HILIC_021 POS

Time: 120 min • Dose: 0 g • Batch: 3
L-Leucine 2,440,992
L-Glutamic Acid 1,337,209
Pyridoxamine dihydrochloride 313,294
L-Serine 310,178
L-Asparagine 224,375

20180212_TOFI2_B3_HILIC_027 POS

Time: 120 min • Dose: 12.5 g • Batch: 3
L-Leucine 3,650,004
L-Glutamic Acid 1,360,041
Pyridoxamine dihydrochloride 296,209
Citrulline 285,265
L-Serine 281,487

20180212_TOFI2_B3_HILIC_027 POS

Time: 120 min • Dose: 12.5 g • Batch: 3
L-Leucine 3,650,004
L-Glutamic Acid 1,360,041
Pyridoxamine dihydrochloride 296,209
Citrulline 285,265
L-Serine 281,487

20180212_TOFI2_B3_HILIC_017 POS

Time: 240 min • Dose: 50 g • Batch: 3
L-Leucine 5,803,048
L-Glutamic Acid 1,389,950
Citrulline 410,874
L-Tyrosine 372,451
L-Isoleucine 354,122

20180212_TOFI2_B3_HILIC_017 POS

Time: 240 min • Dose: 50 g • Batch: 3
L-Leucine 5,803,048
L-Glutamic Acid 1,389,950
Citrulline 410,874
L-Tyrosine 372,451
L-Isoleucine 354,122

20180212_TOFI2_B3_HILIC_022 POS

Time: 240 min • Dose: 0 g • Batch: 3
L-Leucine 2,612,415
L-Glutamic Acid 1,350,930
Pyridoxamine dihydrochloride 325,231
L-Serine 313,306
L-Asparagine 224,425

20180212_TOFI2_B3_HILIC_022 POS

Time: 240 min • Dose: 0 g • Batch: 3
L-Leucine 2,612,415
L-Glutamic Acid 1,350,930
Pyridoxamine dihydrochloride 325,231
L-Serine 313,306
L-Asparagine 224,425

20180212_TOFI2_B3_HILIC_028 POS

Time: 240 min • Dose: 12.5 g • Batch: 3
L-Leucine 3,195,350
L-Glutamic Acid 1,273,542
Pyridoxamine dihydrochloride 335,693
L-Serine 282,779
L-Asparagine 226,355

20180212_TOFI2_B3_HILIC_028 POS

Time: 240 min • Dose: 12.5 g • Batch: 3
L-Leucine 3,195,350
L-Glutamic Acid 1,273,542
Pyridoxamine dihydrochloride 335,693
L-Serine 282,779
L-Asparagine 226,355
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