LD4227

MTBLS5568 • Plasma LC-MS metabolomics • Prediabetes whey-protein intervention

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Female Sex
33 yr Age
22.8 BMI
2.9% MRI Pancreas Fat
30 Total Samples (30 POS + 0 NEG)
5 Timepoints: 0, 30, 60, 120, 240 min

Top 15 Metabolite Features (Across All Samples)

L-Leucine

Formula: C6H13NO2 • m/z: 130.0869 • RT: 599.4486
HMDB: HMDB00687 • KEGG: C00123 • Found: 30×
Total abundance
188,864,398

L-Glutamic Acid

Formula: C5H9NO4 • m/z: 146.04542 • RT: 796.2
HMDB: HMDB00148 • KEGG: C00025 • Found: 30×
Total abundance
51,615,295

L-Tyrosine

Formula: C9H11NO3 • m/z: 180.06659 • RT: 700.038
HMDB: HMDB00158 • KEGG: C00082 • Found: 30×
Total abundance
16,092,997

L-Serine

Formula: C3H7NO3 • m/z: 104.03466 • RT: 826.138
HMDB: HMDB00187 • KEGG: C00065 • Found: 28×
Total abundance
14,066,909

Pyridoxamine dihydrochloride

Formula: C8H14Cl2N2O2 • m/z: 133.08047 • RT: 741.336 • Found: 30×
Total abundance
12,796,185

N-Acetylserine

Formula: C5H9NO4 • m/z: 148.06085 • RT: 790.658
HMDB: HMDB02931 • Found: 28×
Total abundance
12,719,190

L-Isoleucine

Formula: C6H13NO2 • m/z: 133.10592 • RT: 589.6156
HMDB: HMDB00172 • KEGG: C00407 • Found: 24×
Total abundance
10,233,485

Citrulline

Formula: C6H13N3O3 • m/z: 174.08819 • RT: 834.04
HMDB: HMDB00904 • KEGG: C00327 • Found: 28×
Total abundance
9,908,679

Methionine sulfoxide

Formula: C5H11NO3S • m/z: 164.03856 • RT: 769.768
HMDB: HMDB02005 • KEGG: C02989 • Found: 26×
Total abundance
9,279,926

L-Methionine

Formula: C5H11NO2S • m/z: 148.04348 • RT: 640.282
HMDB: HMDB00696 • KEGG: C00073 • Found: 22×
Total abundance
7,286,138

L-Asparagine

Formula: C4H8N2O3 • m/z: 131.04572 • RT: 821.266
HMDB: HMDB00168 • KEGG: C00152 • Found: 18×
Total abundance
4,643,773

Leucine

Formula: C6H13NO2 • m/z: 133.10591 • RT: 603.562
HMDB: HMDB00687 • KEGG: C00123 • Found: 4×
Total abundance
2,141,962

L-2-Aminoadipic acid

Formula: C6H11NO4 • m/z: 162.07635 • RT: 756.777
HMDB: HMDB00510 • KEGG: C00956 • Found: 2×
Total abundance
1,108,625

Sample Timecourse (30 samples)

WPI Dose: 0 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180205_TOFI2_B2_HILIC_046 2 L-Leucine 12,252,381 L-Glutamic Acid 1,804,726 N-Acetylserine 1,045,051
0 POS 20180205_TOFI2_B2_HILIC_046 2 L-Leucine 12,252,381 L-Glutamic Acid 1,804,726 N-Acetylserine 1,045,051
30 POS 20180205_TOFI2_B2_HILIC_047 2 L-Leucine 3,203,900 L-Glutamic Acid 1,709,385 L-Serine 512,928
30 POS 20180205_TOFI2_B2_HILIC_047 2 L-Leucine 3,203,900 L-Glutamic Acid 1,709,385 L-Serine 512,928
60 POS 20180205_TOFI2_B2_HILIC_048 2 L-Leucine 3,484,758 L-Glutamic Acid 1,750,319 L-Serine 536,003
60 POS 20180205_TOFI2_B2_HILIC_048 2 L-Leucine 3,484,758 L-Glutamic Acid 1,750,319 L-Serine 536,003
120 POS 20180205_TOFI2_B2_HILIC_049 2 L-Leucine 3,903,099 L-Glutamic Acid 1,804,367 L-Serine 533,846
120 POS 20180205_TOFI2_B2_HILIC_049 2 L-Leucine 3,903,099 L-Glutamic Acid 1,804,367 L-Serine 533,846
240 POS 20180205_TOFI2_B2_HILIC_050 2 L-Leucine 3,440,239 L-Glutamic Acid 1,767,830 L-Serine 529,074
240 POS 20180205_TOFI2_B2_HILIC_050 2 L-Leucine 3,440,239 L-Glutamic Acid 1,767,830 L-Serine 529,074

WPI Dose: 12.5 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180205_TOFI2_B2_HILIC_051 2 L-Leucine 3,641,536 L-Glutamic Acid 1,784,586 L-Serine 537,691
0 POS 20180205_TOFI2_B2_HILIC_051 2 L-Leucine 3,641,536 L-Glutamic Acid 1,784,586 L-Serine 537,691
30 POS 20180205_TOFI2_B2_HILIC_052 2 L-Leucine 4,603,309 L-Glutamic Acid 1,633,902 L-Tyrosine 532,949
30 POS 20180205_TOFI2_B2_HILIC_052 2 L-Leucine 4,603,309 L-Glutamic Acid 1,633,902 L-Tyrosine 532,949
60 POS 20180205_TOFI2_B2_HILIC_053 2 L-Leucine 4,330,263 L-Glutamic Acid 1,786,091 L-Tyrosine 562,717
60 POS 20180205_TOFI2_B2_HILIC_053 2 L-Leucine 4,330,263 L-Glutamic Acid 1,786,091 L-Tyrosine 562,717
120 POS 20180205_TOFI2_B2_HILIC_054 2 L-Leucine 9,052,132 L-Glutamic Acid 938,547 L-Tyrosine 744,644
120 POS 20180205_TOFI2_B2_HILIC_054 2 L-Leucine 9,052,132 L-Glutamic Acid 938,547 L-Tyrosine 744,644
240 POS 20180205_TOFI2_B2_HILIC_055 2 L-Leucine 6,458,687 L-Glutamic Acid 1,823,865 L-Tyrosine 554,543
240 POS 20180205_TOFI2_B2_HILIC_055 2 L-Leucine 6,458,687 L-Glutamic Acid 1,823,865 L-Tyrosine 554,543

WPI Dose: 50 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180205_TOFI2_B2_HILIC_057 2 L-Leucine 4,347,958 L-Glutamic Acid 1,794,825 L-Serine 474,918
0 POS 20180205_TOFI2_B2_HILIC_057 2 L-Leucine 4,347,958 L-Glutamic Acid 1,794,825 L-Serine 474,918
30 POS 20180205_TOFI2_B2_HILIC_058 2 L-Leucine 3,160,681 L-Glutamic Acid 1,665,443 L-Serine 438,057
30 POS 20180205_TOFI2_B2_HILIC_058 2 L-Leucine 3,160,681 L-Glutamic Acid 1,665,443 L-Serine 438,057
60 POS 20180205_TOFI2_B2_HILIC_059 2 L-Leucine 4,028,533 L-Glutamic Acid 1,759,809 L-Serine 468,126
60 POS 20180205_TOFI2_B2_HILIC_059 2 L-Leucine 4,028,533 L-Glutamic Acid 1,759,809 L-Serine 468,126
120 POS 20180205_TOFI2_B2_HILIC_060 2 L-Leucine 14,372,546 L-Glutamic Acid 1,929,235 L-Tyrosine 1,005,009
120 POS 20180205_TOFI2_B2_HILIC_060 2 L-Leucine 14,372,546 L-Glutamic Acid 1,929,235 L-Tyrosine 1,005,009
240 POS 20180205_TOFI2_B2_HILIC_061 2 L-Leucine 14,152,177 L-Glutamic Acid 1,854,720 N-Acetylserine 923,042
240 POS 20180205_TOFI2_B2_HILIC_061 2 L-Leucine 14,152,177 L-Glutamic Acid 1,854,720 N-Acetylserine 923,042

All Samples

20180205_TOFI2_B2_HILIC_046 POS

Time: 0 min • Dose: 0 g • Batch: 2
L-Leucine 12,252,381
L-Glutamic Acid 1,804,726
N-Acetylserine 1,045,051
L-Tyrosine 773,589
L-Isoleucine 758,880

20180205_TOFI2_B2_HILIC_046 POS

Time: 0 min • Dose: 0 g • Batch: 2
L-Leucine 12,252,381
L-Glutamic Acid 1,804,726
N-Acetylserine 1,045,051
L-Tyrosine 773,589
L-Isoleucine 758,880

20180205_TOFI2_B2_HILIC_051 POS

Time: 0 min • Dose: 12.5 g • Batch: 2
L-Leucine 3,641,536
L-Glutamic Acid 1,784,586
L-Serine 537,691
Pyridoxamine dihydrochloride 405,260
N-Acetylserine 363,358

20180205_TOFI2_B2_HILIC_051 POS

Time: 0 min • Dose: 12.5 g • Batch: 2
L-Leucine 3,641,536
L-Glutamic Acid 1,784,586
L-Serine 537,691
Pyridoxamine dihydrochloride 405,260
N-Acetylserine 363,358

20180205_TOFI2_B2_HILIC_057 POS

Time: 0 min • Dose: 50 g • Batch: 2
L-Leucine 4,347,958
L-Glutamic Acid 1,794,825
L-Serine 474,918
L-Tyrosine 433,948
Pyridoxamine dihydrochloride 425,104

20180205_TOFI2_B2_HILIC_057 POS

Time: 0 min • Dose: 50 g • Batch: 2
L-Leucine 4,347,958
L-Glutamic Acid 1,794,825
L-Serine 474,918
L-Tyrosine 433,948
Pyridoxamine dihydrochloride 425,104

20180205_TOFI2_B2_HILIC_047 POS

Time: 30 min • Dose: 0 g • Batch: 2
L-Leucine 3,203,900
L-Glutamic Acid 1,709,385
L-Serine 512,928
Pyridoxamine dihydrochloride 408,069
L-Tyrosine 357,982

20180205_TOFI2_B2_HILIC_047 POS

Time: 30 min • Dose: 0 g • Batch: 2
L-Leucine 3,203,900
L-Glutamic Acid 1,709,385
L-Serine 512,928
Pyridoxamine dihydrochloride 408,069
L-Tyrosine 357,982

20180205_TOFI2_B2_HILIC_052 POS

Time: 30 min • Dose: 12.5 g • Batch: 2
L-Leucine 4,603,309
L-Glutamic Acid 1,633,902
L-Tyrosine 532,949
L-Serine 486,100
Pyridoxamine dihydrochloride 427,361

20180205_TOFI2_B2_HILIC_052 POS

Time: 30 min • Dose: 12.5 g • Batch: 2
L-Leucine 4,603,309
L-Glutamic Acid 1,633,902
L-Tyrosine 532,949
L-Serine 486,100
Pyridoxamine dihydrochloride 427,361

20180205_TOFI2_B2_HILIC_058 POS

Time: 30 min • Dose: 50 g • Batch: 2
L-Leucine 3,160,681
L-Glutamic Acid 1,665,443
L-Serine 438,057
Pyridoxamine dihydrochloride 388,462
L-Tyrosine 378,019

20180205_TOFI2_B2_HILIC_058 POS

Time: 30 min • Dose: 50 g • Batch: 2
L-Leucine 3,160,681
L-Glutamic Acid 1,665,443
L-Serine 438,057
Pyridoxamine dihydrochloride 388,462
L-Tyrosine 378,019

20180205_TOFI2_B2_HILIC_048 POS

Time: 60 min • Dose: 0 g • Batch: 2
L-Leucine 3,484,758
L-Glutamic Acid 1,750,319
L-Serine 536,003
Pyridoxamine dihydrochloride 396,701
L-Tyrosine 368,369

20180205_TOFI2_B2_HILIC_048 POS

Time: 60 min • Dose: 0 g • Batch: 2
L-Leucine 3,484,758
L-Glutamic Acid 1,750,319
L-Serine 536,003
Pyridoxamine dihydrochloride 396,701
L-Tyrosine 368,369

20180205_TOFI2_B2_HILIC_053 POS

Time: 60 min • Dose: 12.5 g • Batch: 2
L-Leucine 4,330,263
L-Glutamic Acid 1,786,091
L-Tyrosine 562,717
L-Serine 512,148
Pyridoxamine dihydrochloride 440,770

20180205_TOFI2_B2_HILIC_053 POS

Time: 60 min • Dose: 12.5 g • Batch: 2
L-Leucine 4,330,263
L-Glutamic Acid 1,786,091
L-Tyrosine 562,717
L-Serine 512,148
Pyridoxamine dihydrochloride 440,770

20180205_TOFI2_B2_HILIC_059 POS

Time: 60 min • Dose: 50 g • Batch: 2
L-Leucine 4,028,533
L-Glutamic Acid 1,759,809
L-Serine 468,126
Pyridoxamine dihydrochloride 397,472
L-Tyrosine 394,547

20180205_TOFI2_B2_HILIC_059 POS

Time: 60 min • Dose: 50 g • Batch: 2
L-Leucine 4,028,533
L-Glutamic Acid 1,759,809
L-Serine 468,126
Pyridoxamine dihydrochloride 397,472
L-Tyrosine 394,547

20180205_TOFI2_B2_HILIC_049 POS

Time: 120 min • Dose: 0 g • Batch: 2
L-Leucine 3,903,099
L-Glutamic Acid 1,804,367
L-Serine 533,846
Pyridoxamine dihydrochloride 372,804
L-Tyrosine 363,712

20180205_TOFI2_B2_HILIC_049 POS

Time: 120 min • Dose: 0 g • Batch: 2
L-Leucine 3,903,099
L-Glutamic Acid 1,804,367
L-Serine 533,846
Pyridoxamine dihydrochloride 372,804
L-Tyrosine 363,712

20180205_TOFI2_B2_HILIC_054 POS

Time: 120 min • Dose: 12.5 g • Batch: 2
L-Leucine 9,052,132
L-Glutamic Acid 938,547
L-Tyrosine 744,644
L-Isoleucine 560,510
L-Serine 559,710

20180205_TOFI2_B2_HILIC_054 POS

Time: 120 min • Dose: 12.5 g • Batch: 2
L-Leucine 9,052,132
L-Glutamic Acid 938,547
L-Tyrosine 744,644
L-Isoleucine 560,510
L-Serine 559,710

20180205_TOFI2_B2_HILIC_060 POS

Time: 120 min • Dose: 50 g • Batch: 2
L-Leucine 14,372,546
L-Glutamic Acid 1,929,235
L-Tyrosine 1,005,009
L-Isoleucine 888,124
N-Acetylserine 708,014

20180205_TOFI2_B2_HILIC_060 POS

Time: 120 min • Dose: 50 g • Batch: 2
L-Leucine 14,372,546
L-Glutamic Acid 1,929,235
L-Tyrosine 1,005,009
L-Isoleucine 888,124
N-Acetylserine 708,014

20180205_TOFI2_B2_HILIC_050 POS

Time: 240 min • Dose: 0 g • Batch: 2
L-Leucine 3,440,239
L-Glutamic Acid 1,767,830
L-Serine 529,074
Pyridoxamine dihydrochloride 363,555
L-Tyrosine 328,511

20180205_TOFI2_B2_HILIC_050 POS

Time: 240 min • Dose: 0 g • Batch: 2
L-Leucine 3,440,239
L-Glutamic Acid 1,767,830
L-Serine 529,074
Pyridoxamine dihydrochloride 363,555
L-Tyrosine 328,511

20180205_TOFI2_B2_HILIC_055 POS

Time: 240 min • Dose: 12.5 g • Batch: 2
L-Leucine 6,458,687
L-Glutamic Acid 1,823,865
L-Tyrosine 554,543
L-Serine 470,692
Pyridoxamine dihydrochloride 462,590

20180205_TOFI2_B2_HILIC_055 POS

Time: 240 min • Dose: 12.5 g • Batch: 2
L-Leucine 6,458,687
L-Glutamic Acid 1,823,865
L-Tyrosine 554,543
L-Serine 470,692
Pyridoxamine dihydrochloride 462,590

20180205_TOFI2_B2_HILIC_061 POS

Time: 240 min • Dose: 50 g • Batch: 2
L-Leucine 14,152,177
L-Glutamic Acid 1,854,720
N-Acetylserine 923,042
L-Isoleucine 917,162
L-Tyrosine 909,676

20180205_TOFI2_B2_HILIC_061 POS

Time: 240 min • Dose: 50 g • Batch: 2
L-Leucine 14,152,177
L-Glutamic Acid 1,854,720
N-Acetylserine 923,042
L-Isoleucine 917,162
L-Tyrosine 909,676
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