QH4225

MTBLS5568 • Plasma LC-MS metabolomics • Prediabetes whey-protein intervention

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Female Sex
32 yr Age
25.3 BMI
2.1% MRI Pancreas Fat
30 Total Samples (30 POS + 0 NEG)
5 Timepoints: 0, 30, 60, 120, 240 min

Top 15 Metabolite Features (Across All Samples)

L-Leucine

Formula: C6H13NO2 • m/z: 130.0869 • RT: 599.4486
HMDB: HMDB00687 • KEGG: C00123 • Found: 30×
Total abundance
178,124,677

L-Glutamic Acid

Formula: C5H9NO4 • m/z: 146.04542 • RT: 796.2
HMDB: HMDB00148 • KEGG: C00025 • Found: 30×
Total abundance
59,091,604

L-Serine

Formula: C3H7NO3 • m/z: 104.03466 • RT: 826.138
HMDB: HMDB00187 • KEGG: C00065 • Found: 30×
Total abundance
15,312,404

L-Tyrosine

Formula: C9H11NO3 • m/z: 180.06659 • RT: 700.038
HMDB: HMDB00158 • KEGG: C00082 • Found: 30×
Total abundance
14,499,635

L-Asparagine

Formula: C4H8N2O3 • m/z: 131.04572 • RT: 821.266
HMDB: HMDB00168 • KEGG: C00152 • Found: 30×
Total abundance
12,742,418

Citrulline

Formula: C6H13N3O3 • m/z: 174.08819 • RT: 834.04
HMDB: HMDB00904 • KEGG: C00327 • Found: 30×
Total abundance
11,607,199

Pyridoxamine dihydrochloride

Formula: C8H14Cl2N2O2 • m/z: 133.08047 • RT: 741.336 • Found: 28×
Total abundance
10,255,996

Methionine sulfoxide

Formula: C5H11NO3S • m/z: 164.03856 • RT: 769.768
HMDB: HMDB02005 • KEGG: C02989 • Found: 28×
Total abundance
9,600,758

L-Methionine

Formula: C5H11NO2S • m/z: 148.04348 • RT: 640.282
HMDB: HMDB00696 • KEGG: C00073 • Found: 30×
Total abundance
9,172,403

L-Isoleucine

Formula: C6H13NO2 • m/z: 133.10592 • RT: 589.6156
HMDB: HMDB00172 • KEGG: C00407 • Found: 18×
Total abundance
8,674,104

N-Acetylserine

Formula: C5H9NO4 • m/z: 148.06085 • RT: 790.658
HMDB: HMDB02931 • Found: 12×
Total abundance
4,292,589

Leucine

Formula: C6H13NO2 • m/z: 133.10591 • RT: 603.562
HMDB: HMDB00687 • KEGG: C00123 • Found: 2×
Total abundance
909,154

Glycine

Formula: C2H5NO2 • m/z: 76.03997 • RT: 800.582
HMDB: HMDB00123 • KEGG: C00037 • Found: 2×
Total abundance
340,587

Sample Timecourse (30 samples)

WPI Dose: 12.5 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180205_TOFI2_B2_HILIC_062 2 L-Leucine 3,035,243 L-Glutamic Acid 1,900,921 L-Serine 478,837
0 POS 20180205_TOFI2_B2_HILIC_062 2 L-Leucine 3,035,243 L-Glutamic Acid 1,900,921 L-Serine 478,837
30 POS 20180205_TOFI2_B2_HILIC_063 2 L-Leucine 7,901,439 L-Glutamic Acid 2,094,154 L-Serine 594,627
30 POS 20180205_TOFI2_B2_HILIC_063 2 L-Leucine 7,901,439 L-Glutamic Acid 2,094,154 L-Serine 594,627
60 POS 20180205_TOFI2_B2_HILIC_064 2 L-Leucine 8,204,711 L-Glutamic Acid 2,054,414 L-Serine 545,935
60 POS 20180205_TOFI2_B2_HILIC_064 2 L-Leucine 8,204,711 L-Glutamic Acid 2,054,414 L-Serine 545,935
120 POS 20180205_TOFI2_B2_HILIC_065 2 L-Leucine 4,981,809 L-Glutamic Acid 1,830,871 L-Serine 477,512
120 POS 20180205_TOFI2_B2_HILIC_065 2 L-Leucine 4,981,809 L-Glutamic Acid 1,830,871 L-Serine 477,512
240 POS 20180205_TOFI2_B2_HILIC_066 2 L-Leucine 3,833,537 L-Glutamic Acid 1,817,722 L-Serine 450,208
240 POS 20180205_TOFI2_B2_HILIC_066 2 L-Leucine 3,833,537 L-Glutamic Acid 1,817,722 L-Serine 450,208

WPI Dose: 50 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180205_TOFI2_B2_HILIC_068 2 L-Leucine 2,848,616 L-Glutamic Acid 1,823,572 L-Serine 462,866
0 POS 20180205_TOFI2_B2_HILIC_068 2 L-Leucine 2,848,616 L-Glutamic Acid 1,823,572 L-Serine 462,866
30 POS 20180205_TOFI2_B2_HILIC_069 2 L-Leucine 9,374,232 L-Glutamic Acid 2,090,150 L-Asparagine 644,930
30 POS 20180205_TOFI2_B2_HILIC_069 2 L-Leucine 9,374,232 L-Glutamic Acid 2,090,150 L-Asparagine 644,930
60 POS 20180205_TOFI2_B2_HILIC_070 2 L-Leucine 12,840,364 L-Glutamic Acid 2,106,074 L-Tyrosine 859,026
60 POS 20180205_TOFI2_B2_HILIC_070 2 L-Leucine 12,840,364 L-Glutamic Acid 2,106,074 L-Tyrosine 859,026
120 POS 20180205_TOFI2_B2_HILIC_071 2 L-Leucine 14,422,792 L-Glutamic Acid 2,112,678 L-Tyrosine 1,129,118
120 POS 20180205_TOFI2_B2_HILIC_071 2 L-Leucine 14,422,792 L-Glutamic Acid 2,112,678 L-Tyrosine 1,129,118
240 POS 20180205_TOFI2_B2_HILIC_072 2 L-Leucine 6,741,365 L-Glutamic Acid 1,698,522 L-Tyrosine 621,679
240 POS 20180205_TOFI2_B2_HILIC_072 2 L-Leucine 6,741,365 L-Glutamic Acid 1,698,522 L-Tyrosine 621,679

WPI Dose: 0 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180205_TOFI2_B2_HILIC_073 2 L-Leucine 2,874,429 L-Glutamic Acid 1,970,022 L-Serine 501,933
0 POS 20180205_TOFI2_B2_HILIC_073 2 L-Leucine 2,874,429 L-Glutamic Acid 1,970,022 L-Serine 501,933
30 POS 20180205_TOFI2_B2_HILIC_074 2 L-Leucine 3,045,609 L-Glutamic Acid 2,029,517 L-Serine 513,596
30 POS 20180205_TOFI2_B2_HILIC_074 2 L-Leucine 3,045,609 L-Glutamic Acid 2,029,517 L-Serine 513,596
60 POS 20180205_TOFI2_B2_HILIC_075 2 L-Leucine 2,938,090 L-Glutamic Acid 2,010,540 L-Serine 503,883
60 POS 20180205_TOFI2_B2_HILIC_075 2 L-Leucine 2,938,090 L-Glutamic Acid 2,010,540 L-Serine 503,883
120 POS 20180205_TOFI2_B2_HILIC_076 2 L-Leucine 2,786,286 L-Glutamic Acid 1,997,141 L-Serine 485,565
120 POS 20180205_TOFI2_B2_HILIC_076 2 L-Leucine 2,786,286 L-Glutamic Acid 1,997,141 L-Serine 485,565
240 POS 20180205_TOFI2_B2_HILIC_077 2 L-Leucine 3,233,815 L-Glutamic Acid 2,009,503 L-Serine 496,974
240 POS 20180205_TOFI2_B2_HILIC_077 2 L-Leucine 3,233,815 L-Glutamic Acid 2,009,503 L-Serine 496,974

All Samples

20180205_TOFI2_B2_HILIC_062 POS

Time: 0 min • Dose: 12.5 g • Batch: 2
L-Leucine 3,035,243
L-Glutamic Acid 1,900,921
L-Serine 478,837
L-Asparagine 339,661
Pyridoxamine dihydrochloride 324,862

20180205_TOFI2_B2_HILIC_062 POS

Time: 0 min • Dose: 12.5 g • Batch: 2
L-Leucine 3,035,243
L-Glutamic Acid 1,900,921
L-Serine 478,837
L-Asparagine 339,661
Pyridoxamine dihydrochloride 324,862

20180205_TOFI2_B2_HILIC_068 POS

Time: 0 min • Dose: 50 g • Batch: 2
L-Leucine 2,848,616
L-Glutamic Acid 1,823,572
L-Serine 462,866
Methionine sulfoxide 352,404
L-Asparagine 338,404

20180205_TOFI2_B2_HILIC_068 POS

Time: 0 min • Dose: 50 g • Batch: 2
L-Leucine 2,848,616
L-Glutamic Acid 1,823,572
L-Serine 462,866
Methionine sulfoxide 352,404
L-Asparagine 338,404

20180205_TOFI2_B2_HILIC_073 POS

Time: 0 min • Dose: 0 g • Batch: 2
L-Leucine 2,874,429
L-Glutamic Acid 1,970,022
L-Serine 501,933
Pyridoxamine dihydrochloride 398,077
Citrulline 396,135

20180205_TOFI2_B2_HILIC_073 POS

Time: 0 min • Dose: 0 g • Batch: 2
L-Leucine 2,874,429
L-Glutamic Acid 1,970,022
L-Serine 501,933
Pyridoxamine dihydrochloride 398,077
Citrulline 396,135

20180205_TOFI2_B2_HILIC_063 POS

Time: 30 min • Dose: 12.5 g • Batch: 2
L-Leucine 7,901,439
L-Glutamic Acid 2,094,154
L-Serine 594,627
L-Tyrosine 573,319
L-Asparagine 532,387

20180205_TOFI2_B2_HILIC_063 POS

Time: 30 min • Dose: 12.5 g • Batch: 2
L-Leucine 7,901,439
L-Glutamic Acid 2,094,154
L-Serine 594,627
L-Tyrosine 573,319
L-Asparagine 532,387

20180205_TOFI2_B2_HILIC_069 POS

Time: 30 min • Dose: 50 g • Batch: 2
L-Leucine 9,374,232
L-Glutamic Acid 2,090,150
L-Asparagine 644,930
L-Tyrosine 643,857
L-Serine 620,178

20180205_TOFI2_B2_HILIC_069 POS

Time: 30 min • Dose: 50 g • Batch: 2
L-Leucine 9,374,232
L-Glutamic Acid 2,090,150
L-Asparagine 644,930
L-Tyrosine 643,857
L-Serine 620,178

20180205_TOFI2_B2_HILIC_074 POS

Time: 30 min • Dose: 0 g • Batch: 2
L-Leucine 3,045,609
L-Glutamic Acid 2,029,517
L-Serine 513,596
Pyridoxamine dihydrochloride 439,107
N-Acetylserine 417,419

20180205_TOFI2_B2_HILIC_074 POS

Time: 30 min • Dose: 0 g • Batch: 2
L-Leucine 3,045,609
L-Glutamic Acid 2,029,517
L-Serine 513,596
Pyridoxamine dihydrochloride 439,107
N-Acetylserine 417,419

20180205_TOFI2_B2_HILIC_064 POS

Time: 60 min • Dose: 12.5 g • Batch: 2
L-Leucine 8,204,711
L-Glutamic Acid 2,054,414
L-Serine 545,935
L-Tyrosine 536,767
L-Isoleucine 490,326

20180205_TOFI2_B2_HILIC_064 POS

Time: 60 min • Dose: 12.5 g • Batch: 2
L-Leucine 8,204,711
L-Glutamic Acid 2,054,414
L-Serine 545,935
L-Tyrosine 536,767
L-Isoleucine 490,326

20180205_TOFI2_B2_HILIC_070 POS

Time: 60 min • Dose: 50 g • Batch: 2
L-Leucine 12,840,364
L-Glutamic Acid 2,106,074
L-Tyrosine 859,026
L-Isoleucine 776,784
Methionine sulfoxide 640,999

20180205_TOFI2_B2_HILIC_070 POS

Time: 60 min • Dose: 50 g • Batch: 2
L-Leucine 12,840,364
L-Glutamic Acid 2,106,074
L-Tyrosine 859,026
L-Isoleucine 776,784
Methionine sulfoxide 640,999

20180205_TOFI2_B2_HILIC_075 POS

Time: 60 min • Dose: 0 g • Batch: 2
L-Leucine 2,938,090
L-Glutamic Acid 2,010,540
L-Serine 503,883
N-Acetylserine 447,614
Pyridoxamine dihydrochloride 411,874

20180205_TOFI2_B2_HILIC_075 POS

Time: 60 min • Dose: 0 g • Batch: 2
L-Leucine 2,938,090
L-Glutamic Acid 2,010,540
L-Serine 503,883
N-Acetylserine 447,614
Pyridoxamine dihydrochloride 411,874

20180205_TOFI2_B2_HILIC_065 POS

Time: 120 min • Dose: 12.5 g • Batch: 2
L-Leucine 4,981,809
L-Glutamic Acid 1,830,871
L-Serine 477,512
L-Tyrosine 406,698
L-Asparagine 372,457

20180205_TOFI2_B2_HILIC_065 POS

Time: 120 min • Dose: 12.5 g • Batch: 2
L-Leucine 4,981,809
L-Glutamic Acid 1,830,871
L-Serine 477,512
L-Tyrosine 406,698
L-Asparagine 372,457

20180205_TOFI2_B2_HILIC_071 POS

Time: 120 min • Dose: 50 g • Batch: 2
L-Leucine 14,422,792
L-Glutamic Acid 2,112,678
L-Tyrosine 1,129,118
L-Isoleucine 892,160
Methionine sulfoxide 694,670

20180205_TOFI2_B2_HILIC_071 POS

Time: 120 min • Dose: 50 g • Batch: 2
L-Leucine 14,422,792
L-Glutamic Acid 2,112,678
L-Tyrosine 1,129,118
L-Isoleucine 892,160
Methionine sulfoxide 694,670

20180205_TOFI2_B2_HILIC_076 POS

Time: 120 min • Dose: 0 g • Batch: 2
L-Leucine 2,786,286
L-Glutamic Acid 1,997,141
L-Serine 485,565
Citrulline 377,926
Pyridoxamine dihydrochloride 376,832

20180205_TOFI2_B2_HILIC_076 POS

Time: 120 min • Dose: 0 g • Batch: 2
L-Leucine 2,786,286
L-Glutamic Acid 1,997,141
L-Serine 485,565
Citrulline 377,926
Pyridoxamine dihydrochloride 376,832

20180205_TOFI2_B2_HILIC_066 POS

Time: 240 min • Dose: 12.5 g • Batch: 2
L-Leucine 3,833,537
L-Glutamic Acid 1,817,722
L-Serine 450,208
Pyridoxamine dihydrochloride 318,442
L-Asparagine 313,902

20180205_TOFI2_B2_HILIC_066 POS

Time: 240 min • Dose: 12.5 g • Batch: 2
L-Leucine 3,833,537
L-Glutamic Acid 1,817,722
L-Serine 450,208
Pyridoxamine dihydrochloride 318,442
L-Asparagine 313,902

20180205_TOFI2_B2_HILIC_072 POS

Time: 240 min • Dose: 50 g • Batch: 2
L-Leucine 6,741,365
L-Glutamic Acid 1,698,522
L-Tyrosine 621,679
L-Isoleucine 497,018
Citrulline 452,853

20180205_TOFI2_B2_HILIC_072 POS

Time: 240 min • Dose: 50 g • Batch: 2
L-Leucine 6,741,365
L-Glutamic Acid 1,698,522
L-Tyrosine 621,679
L-Isoleucine 497,018
Citrulline 452,853

20180205_TOFI2_B2_HILIC_077 POS

Time: 240 min • Dose: 0 g • Batch: 2
L-Leucine 3,233,815
L-Glutamic Acid 2,009,503
L-Serine 496,974
Pyridoxamine dihydrochloride 391,046
Citrulline 368,000

20180205_TOFI2_B2_HILIC_077 POS

Time: 240 min • Dose: 0 g • Batch: 2
L-Leucine 3,233,815
L-Glutamic Acid 2,009,503
L-Serine 496,974
Pyridoxamine dihydrochloride 391,046
Citrulline 368,000
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