QS4232

MTBLS5568 • Plasma LC-MS metabolomics • Prediabetes whey-protein intervention

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Female Sex
46 yr Age
25.1 BMI
4.7% MRI Pancreas Fat
30 Total Samples (30 POS + 0 NEG)
5 Timepoints: 0, 30, 60, 120, 240 min

Top 15 Metabolite Features (Across All Samples)

L-Leucine

Formula: C6H13NO2 • m/z: 130.0869 • RT: 599.4486
HMDB: HMDB00687 • KEGG: C00123 • Found: 30×
Total abundance
204,417,762

L-Glutamic Acid

Formula: C5H9NO4 • m/z: 146.04542 • RT: 796.2
HMDB: HMDB00148 • KEGG: C00025 • Found: 30×
Total abundance
60,716,164

L-Asparagine

Formula: C4H8N2O3 • m/z: 131.04572 • RT: 821.266
HMDB: HMDB00168 • KEGG: C00152 • Found: 30×
Total abundance
21,603,821

L-Tyrosine

Formula: C9H11NO3 • m/z: 180.06659 • RT: 700.038
HMDB: HMDB00158 • KEGG: C00082 • Found: 30×
Total abundance
15,422,827

Citrulline

Formula: C6H13N3O3 • m/z: 174.08819 • RT: 834.04
HMDB: HMDB00904 • KEGG: C00327 • Found: 30×
Total abundance
14,212,066

L-Serine

Formula: C3H7NO3 • m/z: 104.03466 • RT: 826.138
HMDB: HMDB00187 • KEGG: C00065 • Found: 30×
Total abundance
13,112,255

Pyridoxamine dihydrochloride

Formula: C8H14Cl2N2O2 • m/z: 133.08047 • RT: 741.336 • Found: 30×
Total abundance
12,703,903

L-Isoleucine

Formula: C6H13NO2 • m/z: 133.10592 • RT: 589.6156
HMDB: HMDB00172 • KEGG: C00407 • Found: 22×
Total abundance
11,082,519

L-Methionine

Formula: C5H11NO2S • m/z: 148.04348 • RT: 640.282
HMDB: HMDB00696 • KEGG: C00073 • Found: 28×
Total abundance
9,904,166

Methionine sulfoxide

Formula: C5H11NO3S • m/z: 164.03856 • RT: 769.768
HMDB: HMDB02005 • KEGG: C02989 • Found: 24×
Total abundance
7,468,635

N-Acetylserine

Formula: C5H9NO4 • m/z: 148.06085 • RT: 790.658
HMDB: HMDB02931 • Found: 12×
Total abundance
2,778,548

Leucine

Formula: C6H13NO2 • m/z: 133.10591 • RT: 603.562
HMDB: HMDB00687 • KEGG: C00123 • Found: 4×
Total abundance
1,804,535

Sample Timecourse (30 samples)

WPI Dose: 12.5 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180205_TOFI2_B2_HILIC_079 2 L-Leucine 3,039,975 L-Glutamic Acid 1,796,298 L-Asparagine 599,056
0 POS 20180205_TOFI2_B2_HILIC_079 2 L-Leucine 3,039,975 L-Glutamic Acid 1,796,298 L-Asparagine 599,056
30 POS 20180205_TOFI2_B2_HILIC_080 2 L-Leucine 8,330,294 L-Glutamic Acid 2,191,636 L-Asparagine 899,187
30 POS 20180205_TOFI2_B2_HILIC_080 2 L-Leucine 8,330,294 L-Glutamic Acid 2,191,636 L-Asparagine 899,187
60 POS 20180205_TOFI2_B2_HILIC_081 2 L-Leucine 11,898,096 L-Glutamic Acid 2,262,457 L-Asparagine 989,845
60 POS 20180205_TOFI2_B2_HILIC_081 2 L-Leucine 11,898,096 L-Glutamic Acid 2,262,457 L-Asparagine 989,845
120 POS 20180205_TOFI2_B2_HILIC_082 2 L-Leucine 5,823,148 L-Glutamic Acid 1,926,295 L-Asparagine 614,519
120 POS 20180205_TOFI2_B2_HILIC_082 2 L-Leucine 5,823,148 L-Glutamic Acid 1,926,295 L-Asparagine 614,519
240 POS 20180205_TOFI2_B2_HILIC_083 2 L-Leucine 4,246,097 L-Glutamic Acid 1,806,673 L-Asparagine 556,590
240 POS 20180205_TOFI2_B2_HILIC_083 2 L-Leucine 4,246,097 L-Glutamic Acid 1,806,673 L-Asparagine 556,590

WPI Dose: 50 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180205_TOFI2_B2_HILIC_084 2 L-Leucine 2,997,553 L-Glutamic Acid 1,876,792 L-Asparagine 588,113
0 POS 20180205_TOFI2_B2_HILIC_084 2 L-Leucine 2,997,553 L-Glutamic Acid 1,876,792 L-Asparagine 588,113
30 POS 20180205_TOFI2_B2_HILIC_085 2 L-Leucine 11,264,135 L-Glutamic Acid 2,299,938 L-Asparagine 1,118,385
30 POS 20180205_TOFI2_B2_HILIC_085 2 L-Leucine 11,264,135 L-Glutamic Acid 2,299,938 L-Asparagine 1,118,385
60 POS 20180205_TOFI2_B2_HILIC_086 2 L-Leucine 15,877,148 L-Glutamic Acid 2,360,162 L-Asparagine 1,176,911
60 POS 20180205_TOFI2_B2_HILIC_086 2 L-Leucine 15,877,148 L-Glutamic Acid 2,360,162 L-Asparagine 1,176,911
120 POS 20180205_TOFI2_B2_HILIC_087 2 L-Leucine 13,679,351 L-Glutamic Acid 2,309,960 L-Tyrosine 1,011,655
120 POS 20180205_TOFI2_B2_HILIC_087 2 L-Leucine 13,679,351 L-Glutamic Acid 2,309,960 L-Tyrosine 1,011,655
240 POS 20180205_TOFI2_B2_HILIC_088 2 L-Leucine 11,254,365 L-Glutamic Acid 2,007,187 L-Tyrosine 856,603
240 POS 20180205_TOFI2_B2_HILIC_088 2 L-Leucine 11,254,365 L-Glutamic Acid 2,007,187 L-Tyrosine 856,603

WPI Dose: 0 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180205_TOFI2_B2_HILIC_090 2 L-Leucine 2,855,272 L-Glutamic Acid 1,839,771 L-Asparagine 544,479
0 POS 20180205_TOFI2_B2_HILIC_090 2 L-Leucine 2,855,272 L-Glutamic Acid 1,839,771 L-Asparagine 544,479
30 POS 20180205_TOFI2_B2_HILIC_091 2 L-Leucine 2,795,133 L-Glutamic Acid 1,904,911 L-Asparagine 573,350
30 POS 20180205_TOFI2_B2_HILIC_091 2 L-Leucine 2,795,133 L-Glutamic Acid 1,904,911 L-Asparagine 573,350
60 POS 20180205_TOFI2_B2_HILIC_092 2 L-Leucine 2,635,700 L-Glutamic Acid 1,919,896 L-Asparagine 528,952
60 POS 20180205_TOFI2_B2_HILIC_092 2 L-Leucine 2,635,700 L-Glutamic Acid 1,919,896 L-Asparagine 528,952
120 POS 20180205_TOFI2_B2_HILIC_093 2 L-Leucine 2,647,053 L-Glutamic Acid 2,005,157 L-Asparagine 538,077
120 POS 20180205_TOFI2_B2_HILIC_093 2 L-Leucine 2,647,053 L-Glutamic Acid 2,005,157 L-Asparagine 538,077
240 POS 20180205_TOFI2_B2_HILIC_094 2 L-Leucine 2,865,561 L-Glutamic Acid 1,850,950 L-Asparagine 499,067
240 POS 20180205_TOFI2_B2_HILIC_094 2 L-Leucine 2,865,561 L-Glutamic Acid 1,850,950 L-Asparagine 499,067

All Samples

20180205_TOFI2_B2_HILIC_079 POS

Time: 0 min • Dose: 12.5 g • Batch: 2
L-Leucine 3,039,975
L-Glutamic Acid 1,796,298
L-Asparagine 599,056
L-Serine 400,065
Pyridoxamine dihydrochloride 374,967

20180205_TOFI2_B2_HILIC_079 POS

Time: 0 min • Dose: 12.5 g • Batch: 2
L-Leucine 3,039,975
L-Glutamic Acid 1,796,298
L-Asparagine 599,056
L-Serine 400,065
Pyridoxamine dihydrochloride 374,967

20180205_TOFI2_B2_HILIC_084 POS

Time: 0 min • Dose: 50 g • Batch: 2
L-Leucine 2,997,553
L-Glutamic Acid 1,876,792
L-Asparagine 588,113
L-Serine 393,660
Pyridoxamine dihydrochloride 371,663

20180205_TOFI2_B2_HILIC_084 POS

Time: 0 min • Dose: 50 g • Batch: 2
L-Leucine 2,997,553
L-Glutamic Acid 1,876,792
L-Asparagine 588,113
L-Serine 393,660
Pyridoxamine dihydrochloride 371,663

20180205_TOFI2_B2_HILIC_090 POS

Time: 0 min • Dose: 0 g • Batch: 2
L-Leucine 2,855,272
L-Glutamic Acid 1,839,771
L-Asparagine 544,479
Citrulline 349,215
L-Serine 341,335

20180205_TOFI2_B2_HILIC_090 POS

Time: 0 min • Dose: 0 g • Batch: 2
L-Leucine 2,855,272
L-Glutamic Acid 1,839,771
L-Asparagine 544,479
Citrulline 349,215
L-Serine 341,335

20180205_TOFI2_B2_HILIC_080 POS

Time: 30 min • Dose: 12.5 g • Batch: 2
L-Leucine 8,330,294
L-Glutamic Acid 2,191,636
L-Asparagine 899,187
L-Tyrosine 596,698
Pyridoxamine dihydrochloride 533,544

20180205_TOFI2_B2_HILIC_080 POS

Time: 30 min • Dose: 12.5 g • Batch: 2
L-Leucine 8,330,294
L-Glutamic Acid 2,191,636
L-Asparagine 899,187
L-Tyrosine 596,698
Pyridoxamine dihydrochloride 533,544

20180205_TOFI2_B2_HILIC_085 POS

Time: 30 min • Dose: 50 g • Batch: 2
L-Leucine 11,264,135
L-Glutamic Acid 2,299,938
L-Asparagine 1,118,385
L-Tyrosine 756,746
L-Serine 735,014

20180205_TOFI2_B2_HILIC_085 POS

Time: 30 min • Dose: 50 g • Batch: 2
L-Leucine 11,264,135
L-Glutamic Acid 2,299,938
L-Asparagine 1,118,385
L-Tyrosine 756,746
L-Serine 735,014

20180205_TOFI2_B2_HILIC_091 POS

Time: 30 min • Dose: 0 g • Batch: 2
L-Leucine 2,795,133
L-Glutamic Acid 1,904,911
L-Asparagine 573,350
Citrulline 382,274
Pyridoxamine dihydrochloride 358,869

20180205_TOFI2_B2_HILIC_091 POS

Time: 30 min • Dose: 0 g • Batch: 2
L-Leucine 2,795,133
L-Glutamic Acid 1,904,911
L-Asparagine 573,350
Citrulline 382,274
Pyridoxamine dihydrochloride 358,869

20180205_TOFI2_B2_HILIC_081 POS

Time: 60 min • Dose: 12.5 g • Batch: 2
L-Leucine 11,898,096
L-Glutamic Acid 2,262,457
L-Asparagine 989,845
L-Tyrosine 735,316
L-Isoleucine 703,078

20180205_TOFI2_B2_HILIC_081 POS

Time: 60 min • Dose: 12.5 g • Batch: 2
L-Leucine 11,898,096
L-Glutamic Acid 2,262,457
L-Asparagine 989,845
L-Tyrosine 735,316
L-Isoleucine 703,078

20180205_TOFI2_B2_HILIC_086 POS

Time: 60 min • Dose: 50 g • Batch: 2
L-Leucine 15,877,148
L-Glutamic Acid 2,360,162
L-Asparagine 1,176,911
L-Isoleucine 1,000,530
L-Tyrosine 945,266

20180205_TOFI2_B2_HILIC_086 POS

Time: 60 min • Dose: 50 g • Batch: 2
L-Leucine 15,877,148
L-Glutamic Acid 2,360,162
L-Asparagine 1,176,911
L-Isoleucine 1,000,530
L-Tyrosine 945,266

20180205_TOFI2_B2_HILIC_092 POS

Time: 60 min • Dose: 0 g • Batch: 2
L-Leucine 2,635,700
L-Glutamic Acid 1,919,896
L-Asparagine 528,952
Citrulline 382,237
Pyridoxamine dihydrochloride 340,019

20180205_TOFI2_B2_HILIC_092 POS

Time: 60 min • Dose: 0 g • Batch: 2
L-Leucine 2,635,700
L-Glutamic Acid 1,919,896
L-Asparagine 528,952
Citrulline 382,237
Pyridoxamine dihydrochloride 340,019

20180205_TOFI2_B2_HILIC_082 POS

Time: 120 min • Dose: 12.5 g • Batch: 2
L-Leucine 5,823,148
L-Glutamic Acid 1,926,295
L-Asparagine 614,519
L-Tyrosine 475,920
Citrulline 469,434

20180205_TOFI2_B2_HILIC_082 POS

Time: 120 min • Dose: 12.5 g • Batch: 2
L-Leucine 5,823,148
L-Glutamic Acid 1,926,295
L-Asparagine 614,519
L-Tyrosine 475,920
Citrulline 469,434

20180205_TOFI2_B2_HILIC_087 POS

Time: 120 min • Dose: 50 g • Batch: 2
L-Leucine 13,679,351
L-Glutamic Acid 2,309,960
L-Tyrosine 1,011,655
L-Asparagine 894,977
L-Isoleucine 859,036

20180205_TOFI2_B2_HILIC_087 POS

Time: 120 min • Dose: 50 g • Batch: 2
L-Leucine 13,679,351
L-Glutamic Acid 2,309,960
L-Tyrosine 1,011,655
L-Asparagine 894,977
L-Isoleucine 859,036

20180205_TOFI2_B2_HILIC_093 POS

Time: 120 min • Dose: 0 g • Batch: 2
L-Leucine 2,647,053
L-Glutamic Acid 2,005,157
L-Asparagine 538,077
Citrulline 392,869
L-Serine 352,129

20180205_TOFI2_B2_HILIC_093 POS

Time: 120 min • Dose: 0 g • Batch: 2
L-Leucine 2,647,053
L-Glutamic Acid 2,005,157
L-Asparagine 538,077
Citrulline 392,869
L-Serine 352,129

20180205_TOFI2_B2_HILIC_083 POS

Time: 240 min • Dose: 12.5 g • Batch: 2
L-Leucine 4,246,097
L-Glutamic Acid 1,806,673
L-Asparagine 556,590
Citrulline 380,599
Pyridoxamine dihydrochloride 375,776

20180205_TOFI2_B2_HILIC_083 POS

Time: 240 min • Dose: 12.5 g • Batch: 2
L-Leucine 4,246,097
L-Glutamic Acid 1,806,673
L-Asparagine 556,590
Citrulline 380,599
Pyridoxamine dihydrochloride 375,776

20180205_TOFI2_B2_HILIC_088 POS

Time: 240 min • Dose: 50 g • Batch: 2
L-Leucine 11,254,365
L-Glutamic Acid 2,007,187
L-Tyrosine 856,603
Citrulline 725,459
L-Isoleucine 694,403

20180205_TOFI2_B2_HILIC_088 POS

Time: 240 min • Dose: 50 g • Batch: 2
L-Leucine 11,254,365
L-Glutamic Acid 2,007,187
L-Tyrosine 856,603
Citrulline 725,459
L-Isoleucine 694,403

20180205_TOFI2_B2_HILIC_094 POS

Time: 240 min • Dose: 0 g • Batch: 2
L-Leucine 2,865,561
L-Glutamic Acid 1,850,950
L-Asparagine 499,067
Citrulline 385,054
L-Serine 355,696

20180205_TOFI2_B2_HILIC_094 POS

Time: 240 min • Dose: 0 g • Batch: 2
L-Leucine 2,865,561
L-Glutamic Acid 1,850,950
L-Asparagine 499,067
Citrulline 385,054
L-Serine 355,696
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