RX4211

MTBLS5568 • Plasma LC-MS metabolomics • Prediabetes whey-protein intervention

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Female Sex
37 yr Age
31.1 BMI
5.5% MRI Pancreas Fat
28 Total Samples (28 POS + 0 NEG)
5 Timepoints: 0, 30, 60, 120, 240 min

Top 15 Metabolite Features (Across All Samples)

L-Leucine

Formula: C6H13NO2 • m/z: 130.0869 • RT: 599.4486
HMDB: HMDB00687 • KEGG: C00123 • Found: 28×
Total abundance
153,254,333

L-Glutamic Acid

Formula: C5H9NO4 • m/z: 146.04542 • RT: 796.2
HMDB: HMDB00148 • KEGG: C00025 • Found: 28×
Total abundance
40,294,280

Methionine sulfoxide

Formula: C5H11NO3S • m/z: 164.03856 • RT: 769.768
HMDB: HMDB02005 • KEGG: C02989 • Found: 28×
Total abundance
15,274,273

L-Serine

Formula: C3H7NO3 • m/z: 104.03466 • RT: 826.138
HMDB: HMDB00187 • KEGG: C00065 • Found: 28×
Total abundance
13,212,648

L-Tyrosine

Formula: C9H11NO3 • m/z: 180.06659 • RT: 700.038
HMDB: HMDB00158 • KEGG: C00082 • Found: 28×
Total abundance
12,792,719

Citrulline

Formula: C6H13N3O3 • m/z: 174.08819 • RT: 834.04
HMDB: HMDB00904 • KEGG: C00327 • Found: 28×
Total abundance
8,998,996

L-Isoleucine

Formula: C6H13NO2 • m/z: 133.10592 • RT: 589.6156
HMDB: HMDB00172 • KEGG: C00407 • Found: 26×
Total abundance
8,873,662

Pyridoxamine dihydrochloride

Formula: C8H14Cl2N2O2 • m/z: 133.08047 • RT: 741.336 • Found: 24×
Total abundance
8,699,590

N-Acetylserine

Formula: C5H9NO4 • m/z: 148.06085 • RT: 790.658
HMDB: HMDB02931 • Found: 26×
Total abundance
8,549,255

L-Asparagine

Formula: C4H8N2O3 • m/z: 131.04572 • RT: 821.266
HMDB: HMDB00168 • KEGG: C00152 • Found: 22×
Total abundance
5,682,333

Leucine

Formula: C6H13NO2 • m/z: 133.10591 • RT: 603.562
HMDB: HMDB00687 • KEGG: C00123 • Found: 6×
Total abundance
2,100,756

L-Methionine

Formula: C5H11NO2S • m/z: 148.04348 • RT: 640.282
HMDB: HMDB00696 • KEGG: C00073 • Found: 6×
Total abundance
1,575,625

L-2-Aminoadipic acid

Formula: C6H11NO4 • m/z: 162.07635 • RT: 756.777
HMDB: HMDB00510 • KEGG: C00956 • Found: 2×
Total abundance
1,073,646

Sample Timecourse (28 samples)

WPI Dose: 12.5 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180220_TOFI2_B4_HILIC_094 4 L-Leucine 2,986,926 L-Glutamic Acid 1,254,475 L-Serine 455,281
0 POS 20180220_TOFI2_B4_HILIC_094 4 L-Leucine 2,986,926 L-Glutamic Acid 1,254,475 L-Serine 455,281
30 POS 20180220_TOFI2_B4_HILIC_095 4 L-Leucine 7,901,636 L-Glutamic Acid 1,325,480 Methionine sulfoxide 658,678
30 POS 20180220_TOFI2_B4_HILIC_095 4 L-Leucine 7,901,636 L-Glutamic Acid 1,325,480 Methionine sulfoxide 658,678
60 POS 20180220_TOFI2_B4_HILIC_096 4 L-Leucine 7,104,573 L-Glutamic Acid 1,280,886 Methionine sulfoxide 560,964
60 POS 20180220_TOFI2_B4_HILIC_096 4 L-Leucine 7,104,573 L-Glutamic Acid 1,280,886 Methionine sulfoxide 560,964
120 POS 20180220_TOFI2_B4_HILIC_097 4 L-Leucine 4,475,466 L-Glutamic Acid 1,215,765 L-Serine 450,886
120 POS 20180220_TOFI2_B4_HILIC_097 4 L-Leucine 4,475,466 L-Glutamic Acid 1,215,765 L-Serine 450,886
240 POS 20180220_TOFI2_B4_HILIC_098 4 L-Leucine 3,718,150 L-Glutamic Acid 1,290,795 L-Serine 412,774
240 POS 20180220_TOFI2_B4_HILIC_098 4 L-Leucine 3,718,150 L-Glutamic Acid 1,290,795 L-Serine 412,774

WPI Dose: 50 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180220_TOFI2_B4_HILIC_099 4 L-Leucine 3,151,160 L-Glutamic Acid 1,513,110 Methionine sulfoxide 470,015
0 POS 20180220_TOFI2_B4_HILIC_099 4 L-Leucine 3,151,160 L-Glutamic Acid 1,513,110 Methionine sulfoxide 470,015
30 POS 20180220_TOFI2_B4_HILIC_101 4 L-Leucine 6,413,910 L-Glutamic Acid 1,778,611 Methionine sulfoxide 763,294
30 POS 20180220_TOFI2_B4_HILIC_101 4 L-Leucine 6,413,910 L-Glutamic Acid 1,778,611 Methionine sulfoxide 763,294
60 POS 20180220_TOFI2_B4_HILIC_102 4 L-Leucine 8,728,312 L-Glutamic Acid 1,683,031 Methionine sulfoxide 1,324,161
60 POS 20180220_TOFI2_B4_HILIC_102 4 L-Leucine 8,728,312 L-Glutamic Acid 1,683,031 Methionine sulfoxide 1,324,161
120 POS 20180220_TOFI2_B4_HILIC_103 4 L-Leucine 12,355,778 L-Glutamic Acid 1,560,284 Methionine sulfoxide 1,251,599
120 POS 20180220_TOFI2_B4_HILIC_103 4 L-Leucine 12,355,778 L-Glutamic Acid 1,560,284 Methionine sulfoxide 1,251,599
240 POS 20180220_TOFI2_B4_HILIC_104 4 L-Leucine 7,770,822 L-Glutamic Acid 1,520,980 L-Tyrosine 617,715
240 POS 20180220_TOFI2_B4_HILIC_104 4 L-Leucine 7,770,822 L-Glutamic Acid 1,520,980 L-Tyrosine 617,715

WPI Dose: 0 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180220_TOFI2_B4_HILIC_105 4 L-Leucine 3,177,955 L-Glutamic Acid 1,407,520 L-Serine 462,745
0 POS 20180220_TOFI2_B4_HILIC_105 4 L-Leucine 3,177,955 L-Glutamic Acid 1,407,520 L-Serine 462,745
30 POS 20180220_TOFI2_B4_HILIC_106 4 L-Leucine 2,893,317 L-Glutamic Acid 1,356,096 L-Serine 486,462
30 POS 20180220_TOFI2_B4_HILIC_106 4 L-Leucine 2,893,317 L-Glutamic Acid 1,356,096 L-Serine 486,462
60 POS 20180220_TOFI2_B4_HILIC_107 4 L-Leucine 3,076,298 L-Glutamic Acid 1,453,791 L-Serine 476,820
60 POS 20180220_TOFI2_B4_HILIC_107 4 L-Leucine 3,076,298 L-Glutamic Acid 1,453,791 L-Serine 476,820
240 POS 20180220_TOFI2_B4_HILIC_108 4 L-Leucine 2,872,863 L-Glutamic Acid 1,506,316 L-Serine 483,313
240 POS 20180220_TOFI2_B4_HILIC_108 4 L-Leucine 2,872,863 L-Glutamic Acid 1,506,316 L-Serine 483,313

All Samples

20180220_TOFI2_B4_HILIC_094 POS

Time: 0 min • Dose: 12.5 g • Batch: 4
L-Leucine 2,986,926
L-Glutamic Acid 1,254,475
L-Serine 455,281
Methionine sulfoxide 358,943
Pyridoxamine dihydrochloride 344,942

20180220_TOFI2_B4_HILIC_094 POS

Time: 0 min • Dose: 12.5 g • Batch: 4
L-Leucine 2,986,926
L-Glutamic Acid 1,254,475
L-Serine 455,281
Methionine sulfoxide 358,943
Pyridoxamine dihydrochloride 344,942

20180220_TOFI2_B4_HILIC_099 POS

Time: 0 min • Dose: 50 g • Batch: 4
L-Leucine 3,151,160
L-Glutamic Acid 1,513,110
Methionine sulfoxide 470,015
L-Serine 465,629
L-Tyrosine 390,993

20180220_TOFI2_B4_HILIC_099 POS

Time: 0 min • Dose: 50 g • Batch: 4
L-Leucine 3,151,160
L-Glutamic Acid 1,513,110
Methionine sulfoxide 470,015
L-Serine 465,629
L-Tyrosine 390,993

20180220_TOFI2_B4_HILIC_105 POS

Time: 0 min • Dose: 0 g • Batch: 4
L-Leucine 3,177,955
L-Glutamic Acid 1,407,520
L-Serine 462,745
Methionine sulfoxide 349,623
L-Tyrosine 333,510

20180220_TOFI2_B4_HILIC_105 POS

Time: 0 min • Dose: 0 g • Batch: 4
L-Leucine 3,177,955
L-Glutamic Acid 1,407,520
L-Serine 462,745
Methionine sulfoxide 349,623
L-Tyrosine 333,510

20180220_TOFI2_B4_HILIC_095 POS

Time: 30 min • Dose: 12.5 g • Batch: 4
L-Leucine 7,901,636
L-Glutamic Acid 1,325,480
Methionine sulfoxide 658,678
L-Serine 542,550
L-Tyrosine 517,594

20180220_TOFI2_B4_HILIC_095 POS

Time: 30 min • Dose: 12.5 g • Batch: 4
L-Leucine 7,901,636
L-Glutamic Acid 1,325,480
Methionine sulfoxide 658,678
L-Serine 542,550
L-Tyrosine 517,594

20180220_TOFI2_B4_HILIC_101 POS

Time: 30 min • Dose: 50 g • Batch: 4
L-Leucine 6,413,910
L-Glutamic Acid 1,778,611
Methionine sulfoxide 763,294
L-Tyrosine 564,906
L-Serine 532,854

20180220_TOFI2_B4_HILIC_101 POS

Time: 30 min • Dose: 50 g • Batch: 4
L-Leucine 6,413,910
L-Glutamic Acid 1,778,611
Methionine sulfoxide 763,294
L-Tyrosine 564,906
L-Serine 532,854

20180220_TOFI2_B4_HILIC_106 POS

Time: 30 min • Dose: 0 g • Batch: 4
L-Leucine 2,893,317
L-Glutamic Acid 1,356,096
L-Serine 486,462
Pyridoxamine dihydrochloride 326,321
N-Acetylserine 323,737

20180220_TOFI2_B4_HILIC_106 POS

Time: 30 min • Dose: 0 g • Batch: 4
L-Leucine 2,893,317
L-Glutamic Acid 1,356,096
L-Serine 486,462
Pyridoxamine dihydrochloride 326,321
N-Acetylserine 323,737

20180220_TOFI2_B4_HILIC_096 POS

Time: 60 min • Dose: 12.5 g • Batch: 4
L-Leucine 7,104,573
L-Glutamic Acid 1,280,886
Methionine sulfoxide 560,964
L-Tyrosine 496,324
L-Serine 481,464

20180220_TOFI2_B4_HILIC_096 POS

Time: 60 min • Dose: 12.5 g • Batch: 4
L-Leucine 7,104,573
L-Glutamic Acid 1,280,886
Methionine sulfoxide 560,964
L-Tyrosine 496,324
L-Serine 481,464

20180220_TOFI2_B4_HILIC_102 POS

Time: 60 min • Dose: 50 g • Batch: 4
L-Leucine 8,728,312
L-Glutamic Acid 1,683,031
Methionine sulfoxide 1,324,161
L-Tyrosine 771,705
L-Isoleucine 546,654

20180220_TOFI2_B4_HILIC_102 POS

Time: 60 min • Dose: 50 g • Batch: 4
L-Leucine 8,728,312
L-Glutamic Acid 1,683,031
Methionine sulfoxide 1,324,161
L-Tyrosine 771,705
L-Isoleucine 546,654

20180220_TOFI2_B4_HILIC_107 POS

Time: 60 min • Dose: 0 g • Batch: 4
L-Leucine 3,076,298
L-Glutamic Acid 1,453,791
L-Serine 476,820
Methionine sulfoxide 328,939
L-Tyrosine 314,957

20180220_TOFI2_B4_HILIC_107 POS

Time: 60 min • Dose: 0 g • Batch: 4
L-Leucine 3,076,298
L-Glutamic Acid 1,453,791
L-Serine 476,820
Methionine sulfoxide 328,939
L-Tyrosine 314,957

20180220_TOFI2_B4_HILIC_097 POS

Time: 120 min • Dose: 12.5 g • Batch: 4
L-Leucine 4,475,466
L-Glutamic Acid 1,215,765
L-Serine 450,886
N-Acetylserine 362,861
Pyridoxamine dihydrochloride 343,919

20180220_TOFI2_B4_HILIC_097 POS

Time: 120 min • Dose: 12.5 g • Batch: 4
L-Leucine 4,475,466
L-Glutamic Acid 1,215,765
L-Serine 450,886
N-Acetylserine 362,861
Pyridoxamine dihydrochloride 343,919

20180220_TOFI2_B4_HILIC_103 POS

Time: 120 min • Dose: 50 g • Batch: 4
L-Leucine 12,355,778
L-Glutamic Acid 1,560,284
Methionine sulfoxide 1,251,599
L-Tyrosine 858,585
L-Isoleucine 769,811

20180220_TOFI2_B4_HILIC_103 POS

Time: 120 min • Dose: 50 g • Batch: 4
L-Leucine 12,355,778
L-Glutamic Acid 1,560,284
Methionine sulfoxide 1,251,599
L-Tyrosine 858,585
L-Isoleucine 769,811

20180220_TOFI2_B4_HILIC_098 POS

Time: 240 min • Dose: 12.5 g • Batch: 4
L-Leucine 3,718,150
L-Glutamic Acid 1,290,795
L-Serine 412,774
Pyridoxamine dihydrochloride 373,223
N-Acetylserine 301,013

20180220_TOFI2_B4_HILIC_098 POS

Time: 240 min • Dose: 12.5 g • Batch: 4
L-Leucine 3,718,150
L-Glutamic Acid 1,290,795
L-Serine 412,774
Pyridoxamine dihydrochloride 373,223
N-Acetylserine 301,013

20180220_TOFI2_B4_HILIC_104 POS

Time: 240 min • Dose: 50 g • Batch: 4
L-Leucine 7,770,822
L-Glutamic Acid 1,520,980
L-Tyrosine 617,715
L-2-Aminoadipic acid 536,823
Citrulline 523,904

20180220_TOFI2_B4_HILIC_104 POS

Time: 240 min • Dose: 50 g • Batch: 4
L-Leucine 7,770,822
L-Glutamic Acid 1,520,980
L-Tyrosine 617,715
L-2-Aminoadipic acid 536,823
Citrulline 523,904

20180220_TOFI2_B4_HILIC_108 POS

Time: 240 min • Dose: 0 g • Batch: 4
L-Leucine 2,872,863
L-Glutamic Acid 1,506,316
L-Serine 483,313
Pyridoxamine dihydrochloride 288,207
L-Tyrosine 267,359

20180220_TOFI2_B4_HILIC_108 POS

Time: 240 min • Dose: 0 g • Batch: 4
L-Leucine 2,872,863
L-Glutamic Acid 1,506,316
L-Serine 483,313
Pyridoxamine dihydrochloride 288,207
L-Tyrosine 267,359
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