ST4233

MTBLS5568 • Plasma LC-MS metabolomics • Prediabetes whey-protein intervention

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Female Sex
51 yr Age
26.7 BMI
12.2% MRI Pancreas Fat
30 Total Samples (30 POS + 0 NEG)
5 Timepoints: 0, 30, 60, 120, 240 min

Top 15 Metabolite Features (Across All Samples)

L-Leucine

Formula: C6H13NO2 • m/z: 130.0869 • RT: 599.4486
HMDB: HMDB00687 • KEGG: C00123 • Found: 30×
Total abundance
224,140,818

L-Glutamic Acid

Formula: C5H9NO4 • m/z: 146.04542 • RT: 796.2
HMDB: HMDB00148 • KEGG: C00025 • Found: 30×
Total abundance
78,980,293

Citrulline

Formula: C6H13N3O3 • m/z: 174.08819 • RT: 834.04
HMDB: HMDB00904 • KEGG: C00327 • Found: 30×
Total abundance
21,187,877

Methionine sulfoxide

Formula: C5H11NO3S • m/z: 164.03856 • RT: 769.768
HMDB: HMDB02005 • KEGG: C02989 • Found: 30×
Total abundance
17,031,027

L-Tyrosine

Formula: C9H11NO3 • m/z: 180.06659 • RT: 700.038
HMDB: HMDB00158 • KEGG: C00082 • Found: 30×
Total abundance
15,918,439

L-Isoleucine

Formula: C6H13NO2 • m/z: 133.10592 • RT: 589.6156
HMDB: HMDB00172 • KEGG: C00407 • Found: 30×
Total abundance
14,304,039

L-Serine

Formula: C3H7NO3 • m/z: 104.03466 • RT: 826.138
HMDB: HMDB00187 • KEGG: C00065 • Found: 28×
Total abundance
14,246,001

L-Asparagine

Formula: C4H8N2O3 • m/z: 131.04572 • RT: 821.266
HMDB: HMDB00168 • KEGG: C00152 • Found: 28×
Total abundance
13,368,485

Pyridoxamine dihydrochloride

Formula: C8H14Cl2N2O2 • m/z: 133.08047 • RT: 741.336 • Found: 26×
Total abundance
10,220,396

L-Methionine

Formula: C5H11NO2S • m/z: 148.04348 • RT: 640.282
HMDB: HMDB00696 • KEGG: C00073 • Found: 18×
Total abundance
6,105,821

N-Acetylserine

Formula: C5H9NO4 • m/z: 148.06085 • RT: 790.658
HMDB: HMDB02931 • Found: 10×
Total abundance
2,942,797

L-2-Aminoadipic acid

Formula: C6H11NO4 • m/z: 162.07635 • RT: 756.777
HMDB: HMDB00510 • KEGG: C00956 • Found: 4×
Total abundance
2,362,887

Leucine

Formula: C6H13NO2 • m/z: 133.10591 • RT: 603.562
HMDB: HMDB00687 • KEGG: C00123 • Found: 4×
Total abundance
2,062,358

L-Threonine

Formula: C4H9NO3 • m/z: 119.05372 • RT: 771.834
HMDB: HMDB00165 • KEGG: C00186 • Found: 2×
Total abundance
501,360

Sample Timecourse (30 samples)

WPI Dose: 50 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180201_TOFI2_B1_HILIC_013 1 L-Leucine 4,251,585 L-Glutamic Acid 2,202,542 Citrulline 549,623
0 POS 20180201_TOFI2_B1_HILIC_013 1 L-Leucine 4,251,585 L-Glutamic Acid 2,202,542 Citrulline 549,623
30 POS 20180201_TOFI2_B1_HILIC_014 1 L-Leucine 7,797,458 L-Glutamic Acid 2,256,863 Methionine sulfoxide 768,992
30 POS 20180201_TOFI2_B1_HILIC_014 1 L-Leucine 7,797,458 L-Glutamic Acid 2,256,863 Methionine sulfoxide 768,992
60 POS 20180201_TOFI2_B1_HILIC_015 1 L-Leucine 10,796,812 L-Glutamic Acid 2,335,555 Methionine sulfoxide 1,083,265
60 POS 20180201_TOFI2_B1_HILIC_015 1 L-Leucine 10,796,812 L-Glutamic Acid 2,335,555 Methionine sulfoxide 1,083,265
120 POS 20180201_TOFI2_B1_HILIC_016 1 L-Leucine 16,346,598 L-Glutamic Acid 2,353,362 Citrulline 1,073,597
120 POS 20180201_TOFI2_B1_HILIC_016 1 L-Leucine 16,346,598 L-Glutamic Acid 2,353,362 Citrulline 1,073,597
240 POS 20180201_TOFI2_B1_HILIC_017 1 L-Leucine 9,878,623 L-Glutamic Acid 2,272,003 Citrulline 1,002,087
240 POS 20180201_TOFI2_B1_HILIC_017 1 L-Leucine 9,878,623 L-Glutamic Acid 2,272,003 Citrulline 1,002,087

WPI Dose: 0 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180201_TOFI2_B1_HILIC_018 1 L-Leucine 3,240,476 L-Glutamic Acid 2,205,329 Citrulline 551,485
0 POS 20180201_TOFI2_B1_HILIC_018 1 L-Leucine 3,240,476 L-Glutamic Acid 2,205,329 Citrulline 551,485
30 POS 20180201_TOFI2_B1_HILIC_019 1 L-Leucine 3,287,509 L-Glutamic Acid 2,092,286 Citrulline 532,448
30 POS 20180201_TOFI2_B1_HILIC_019 1 L-Leucine 3,287,509 L-Glutamic Acid 2,092,286 Citrulline 532,448
60 POS 20180201_TOFI2_B1_HILIC_020 1 L-Leucine 3,579,830 L-Glutamic Acid 2,747,303 Citrulline 544,645
60 POS 20180201_TOFI2_B1_HILIC_020 1 L-Leucine 3,579,830 L-Glutamic Acid 2,747,303 Citrulline 544,645
120 POS 20180201_TOFI2_B1_HILIC_021 1 L-Leucine 4,375,156 L-Glutamic Acid 4,236,549 Citrulline 620,352
120 POS 20180201_TOFI2_B1_HILIC_021 1 L-Leucine 4,375,156 L-Glutamic Acid 4,236,549 Citrulline 620,352
240 POS 20180201_TOFI2_B1_HILIC_022 1 L-Leucine 8,138,931 L-Glutamic Acid 4,610,701 Citrulline 702,833
240 POS 20180201_TOFI2_B1_HILIC_022 1 L-Leucine 8,138,931 L-Glutamic Acid 4,610,701 Citrulline 702,833

WPI Dose: 12.5 g

Time (min)ModeSource NameBatch #1 MetaboliteAbundance #2 MetaboliteAbundance #3 MetaboliteAbundance
0 POS 20180201_TOFI2_B1_HILIC_024 1 L-Leucine 3,904,884 L-Glutamic Acid 2,272,051 Citrulline 668,850
0 POS 20180201_TOFI2_B1_HILIC_024 1 L-Leucine 3,904,884 L-Glutamic Acid 2,272,051 Citrulline 668,850
30 POS 20180201_TOFI2_B1_HILIC_025 1 L-Leucine 13,675,182 L-Glutamic Acid 2,362,575 Methionine sulfoxide 982,075
30 POS 20180201_TOFI2_B1_HILIC_025 1 L-Leucine 13,675,182 L-Glutamic Acid 2,362,575 Methionine sulfoxide 982,075
60 POS 20180201_TOFI2_B1_HILIC_026 1 L-Leucine 11,506,730 L-Glutamic Acid 2,582,386 L-Isoleucine 1,113,635
60 POS 20180201_TOFI2_B1_HILIC_026 1 L-Leucine 11,506,730 L-Glutamic Acid 2,582,386 L-Isoleucine 1,113,635
120 POS 20180201_TOFI2_B1_HILIC_027 1 L-Leucine 6,266,352 L-Glutamic Acid 2,554,149 Citrulline 801,800
120 POS 20180201_TOFI2_B1_HILIC_027 1 L-Leucine 6,266,352 L-Glutamic Acid 2,554,149 Citrulline 801,800
240 POS 20180201_TOFI2_B1_HILIC_028 1 L-Leucine 5,024,283 L-Glutamic Acid 2,406,492 Citrulline 678,980
240 POS 20180201_TOFI2_B1_HILIC_028 1 L-Leucine 5,024,283 L-Glutamic Acid 2,406,492 Citrulline 678,980

All Samples

20180201_TOFI2_B1_HILIC_013 POS

Time: 0 min • Dose: 50 g • Batch: 1
L-Leucine 4,251,585
L-Glutamic Acid 2,202,542
Citrulline 549,623
Methionine sulfoxide 525,130
L-Serine 435,156

20180201_TOFI2_B1_HILIC_013 POS

Time: 0 min • Dose: 50 g • Batch: 1
L-Leucine 4,251,585
L-Glutamic Acid 2,202,542
Citrulline 549,623
Methionine sulfoxide 525,130
L-Serine 435,156

20180201_TOFI2_B1_HILIC_018 POS

Time: 0 min • Dose: 0 g • Batch: 1
L-Leucine 3,240,476
L-Glutamic Acid 2,205,329
Citrulline 551,485
L-Serine 484,656
L-Asparagine 400,816

20180201_TOFI2_B1_HILIC_018 POS

Time: 0 min • Dose: 0 g • Batch: 1
L-Leucine 3,240,476
L-Glutamic Acid 2,205,329
Citrulline 551,485
L-Serine 484,656
L-Asparagine 400,816

20180201_TOFI2_B1_HILIC_024 POS

Time: 0 min • Dose: 12.5 g • Batch: 1
L-Leucine 3,904,884
L-Glutamic Acid 2,272,051
Citrulline 668,850
Methionine sulfoxide 606,126
L-Serine 539,171

20180201_TOFI2_B1_HILIC_024 POS

Time: 0 min • Dose: 12.5 g • Batch: 1
L-Leucine 3,904,884
L-Glutamic Acid 2,272,051
Citrulline 668,850
Methionine sulfoxide 606,126
L-Serine 539,171

20180201_TOFI2_B1_HILIC_014 POS

Time: 30 min • Dose: 50 g • Batch: 1
L-Leucine 7,797,458
L-Glutamic Acid 2,256,863
Methionine sulfoxide 768,992
Citrulline 609,437
L-Tyrosine 551,963

20180201_TOFI2_B1_HILIC_014 POS

Time: 30 min • Dose: 50 g • Batch: 1
L-Leucine 7,797,458
L-Glutamic Acid 2,256,863
Methionine sulfoxide 768,992
Citrulline 609,437
L-Tyrosine 551,963

20180201_TOFI2_B1_HILIC_019 POS

Time: 30 min • Dose: 0 g • Batch: 1
L-Leucine 3,287,509
L-Glutamic Acid 2,092,286
Citrulline 532,448
L-Serine 435,319
L-Asparagine 400,829

20180201_TOFI2_B1_HILIC_019 POS

Time: 30 min • Dose: 0 g • Batch: 1
L-Leucine 3,287,509
L-Glutamic Acid 2,092,286
Citrulline 532,448
L-Serine 435,319
L-Asparagine 400,829

20180201_TOFI2_B1_HILIC_025 POS

Time: 30 min • Dose: 12.5 g • Batch: 1
L-Leucine 13,675,182
L-Glutamic Acid 2,362,575
Methionine sulfoxide 982,075
L-Isoleucine 831,209
L-Tyrosine 699,416

20180201_TOFI2_B1_HILIC_025 POS

Time: 30 min • Dose: 12.5 g • Batch: 1
L-Leucine 13,675,182
L-Glutamic Acid 2,362,575
Methionine sulfoxide 982,075
L-Isoleucine 831,209
L-Tyrosine 699,416

20180201_TOFI2_B1_HILIC_015 POS

Time: 60 min • Dose: 50 g • Batch: 1
L-Leucine 10,796,812
L-Glutamic Acid 2,335,555
Methionine sulfoxide 1,083,265
Citrulline 718,145
L-Tyrosine 696,290

20180201_TOFI2_B1_HILIC_015 POS

Time: 60 min • Dose: 50 g • Batch: 1
L-Leucine 10,796,812
L-Glutamic Acid 2,335,555
Methionine sulfoxide 1,083,265
Citrulline 718,145
L-Tyrosine 696,290

20180201_TOFI2_B1_HILIC_020 POS

Time: 60 min • Dose: 0 g • Batch: 1
L-Leucine 3,579,830
L-Glutamic Acid 2,747,303
Citrulline 544,645
L-Serine 481,746
L-Asparagine 453,553

20180201_TOFI2_B1_HILIC_020 POS

Time: 60 min • Dose: 0 g • Batch: 1
L-Leucine 3,579,830
L-Glutamic Acid 2,747,303
Citrulline 544,645
L-Serine 481,746
L-Asparagine 453,553

20180201_TOFI2_B1_HILIC_026 POS

Time: 60 min • Dose: 12.5 g • Batch: 1
L-Leucine 11,506,730
L-Glutamic Acid 2,582,386
L-Isoleucine 1,113,635
Citrulline 905,988
L-Tyrosine 788,626

20180201_TOFI2_B1_HILIC_026 POS

Time: 60 min • Dose: 12.5 g • Batch: 1
L-Leucine 11,506,730
L-Glutamic Acid 2,582,386
L-Isoleucine 1,113,635
Citrulline 905,988
L-Tyrosine 788,626

20180201_TOFI2_B1_HILIC_016 POS

Time: 120 min • Dose: 50 g • Batch: 1
L-Leucine 16,346,598
L-Glutamic Acid 2,353,362
Citrulline 1,073,597
L-Isoleucine 1,026,776
Methionine sulfoxide 859,031

20180201_TOFI2_B1_HILIC_016 POS

Time: 120 min • Dose: 50 g • Batch: 1
L-Leucine 16,346,598
L-Glutamic Acid 2,353,362
Citrulline 1,073,597
L-Isoleucine 1,026,776
Methionine sulfoxide 859,031

20180201_TOFI2_B1_HILIC_021 POS

Time: 120 min • Dose: 0 g • Batch: 1
L-Leucine 4,375,156
L-Glutamic Acid 4,236,549
Citrulline 620,352
L-Serine 523,116
L-Asparagine 479,890

20180201_TOFI2_B1_HILIC_021 POS

Time: 120 min • Dose: 0 g • Batch: 1
L-Leucine 4,375,156
L-Glutamic Acid 4,236,549
Citrulline 620,352
L-Serine 523,116
L-Asparagine 479,890

20180201_TOFI2_B1_HILIC_027 POS

Time: 120 min • Dose: 12.5 g • Batch: 1
L-Leucine 6,266,352
L-Glutamic Acid 2,554,149
Citrulline 801,800
L-Tyrosine 565,456
L-Serine 515,484

20180201_TOFI2_B1_HILIC_027 POS

Time: 120 min • Dose: 12.5 g • Batch: 1
L-Leucine 6,266,352
L-Glutamic Acid 2,554,149
Citrulline 801,800
L-Tyrosine 565,456
L-Serine 515,484

20180201_TOFI2_B1_HILIC_017 POS

Time: 240 min • Dose: 50 g • Batch: 1
L-Leucine 9,878,623
L-Glutamic Acid 2,272,003
Citrulline 1,002,087
L-2-Aminoadipic acid 686,715
L-Isoleucine 623,599

20180201_TOFI2_B1_HILIC_017 POS

Time: 240 min • Dose: 50 g • Batch: 1
L-Leucine 9,878,623
L-Glutamic Acid 2,272,003
Citrulline 1,002,087
L-2-Aminoadipic acid 686,715
L-Isoleucine 623,599

20180201_TOFI2_B1_HILIC_022 POS

Time: 240 min • Dose: 0 g • Batch: 1
L-Leucine 8,138,931
L-Glutamic Acid 4,610,701
Citrulline 702,833
L-Serine 598,240
L-Asparagine 524,966

20180201_TOFI2_B1_HILIC_022 POS

Time: 240 min • Dose: 0 g • Batch: 1
L-Leucine 8,138,931
L-Glutamic Acid 4,610,701
Citrulline 702,833
L-Serine 598,240
L-Asparagine 524,966

20180201_TOFI2_B1_HILIC_028 POS

Time: 240 min • Dose: 12.5 g • Batch: 1
L-Leucine 5,024,283
L-Glutamic Acid 2,406,492
Citrulline 678,980
L-Serine 584,869
L-Tyrosine 471,227

20180201_TOFI2_B1_HILIC_028 POS

Time: 240 min • Dose: 12.5 g • Batch: 1
L-Leucine 5,024,283
L-Glutamic Acid 2,406,492
Citrulline 678,980
L-Serine 584,869
L-Tyrosine 471,227
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