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Paper evidence · no local matrix

'Longevity Molecular Tag' immune-cell atlas

Aging Cell · 2026. Raw sequencing is not on this host. What follows is the open paper layer: access route, figure captions with PMC originals, and 1–2 core tables transcribed from the publication.

Public reuse · not local PMID 41784043 PMC12961527 CC BY 4.0
Access truth 56-person East-Asian scRNA reused from Synapse syn61609846 (doi 10.1038/s41590-024-02059-6). Japan 7 SC + 5 controls from RIKEN SC2018. Guangxi bulk: 34 centenarians + 16 controls. No local matrix on LACA.
Open licence. Captions and published numbers may be shown with attribution. Underlying scRNA is reused from Synapse / RIKEN, not generated as a new open GEO series.

Technology

Integrated scRNA-seq + bulk RNA-seq + Scissor + eQTL colocalization

Material

Integrated immune-cell datasets and bulk blood RNA

Local matrix

None. This page is not a donor browser.

Source note

No local matrix. Use the published-evidence page for Scissor / eQTL tables. Participant-level metadata are not in the local manifest, so no tracking donors are generated.

Published sample accounting

Study-reported counts, not deduplicated LACA donors.

Site / layer CEN / SC Offspring Control Note
East-Asian scRNA (Shanghai reuse) 0 0 56 Ages 0 to ≥90; Synapse syn61609846
Japan SC2018 7 0 5 Supercentenarians + controls
Guangxi bulk RNA-seq 34 0 16 Control mean age 52.81 ± 9.78

Paper figure gallery

Captions are curated locally. The images themselves stay on PMC / the publisher. Open the PMC figure page for the original panel.

Fig.1 Aging-cohort transcriptome landscape UMAP of 9 lineages and 21 subpopulations; proportions across age groups. 559,713 cells after QC. Fig.2 Scissor+ / Scissor− map 13,198 Scissor+ vs 18,075 Scissor− vs 21,328 background cells among 52,601 analysed cells. Fig.3 Lineage trajectories NK, CD8, CD4 and B subpopulations with pseudotime. Fig.4 DEG and enrichment 317 up / 147 down DEGs between Scissor+ and Scissor−, with GO / KEGG. Fig.5 Longevity eQTL colocalisation Five events with PP.H4 > 0.7, including rs3793537 and rs8019902.

Core published tables

Transcribed facts from the open full text. Not a re-analysis.

Scissor and DEG counts
Item N Note
Cells after QC 559,713 5,402 excluded
Cells in Scissor analysis 52,601 Subset used for phenotype link
Scissor+ 13,198 NK, CD8, γδ T enriched
Scissor− 18,075 CD4, B, DC enriched
Background 21,328 Neither pole
DEGs up / down 317 / 147 464 total
Uniquely expressed in centenarians 441 Bulk / integration overlay
Source: PMC12961527 results.
eQTL colocalisation (PP.H4 > 0.7)
SNP Genes Locus note
rs3793537 GLIPR2 / CD72 / TLN1 chr9; named in abstract and Fig.5
rs8019902 TRDV2 / TRDC chr14; named in abstract and Fig.5
3 further events see Table S10 PP.H4 > 0.7; not numerically expanded in the main text
Source: Main text + Table S10. Remaining three events are named only in the supplement.

Accessions and exits

PMC full text ↗ PubMed ↗ Publisher ↗ syn61609846 · 56-person scRNA reuse ↗ RIKEN SC2018 · 7 supercentenarians + 5 controls ↗ NCT05206643 · Related trial record ↗ eQTLGen sc · cis-eQTL used for colocalisation ↗