⚙ How is this computed? Methods: Cross-Species Comparison

Gene Longevity Correlation

Query the Spearman rank correlation between a gene's expression level and maximum lifespan across all LACA species in which the queried gene has a confidently mapped ortholog and detectable expression; the exact species set is reported with each result.

Accepts any standard HGNC gene symbol

Popular: TP53 SIRT1 FOXO3 TERT MTOR KLOTHO IGF1R SOD2 LMNA BECN1 PARP1 WRN

Analysis Result

SIRT1
Spearman ฯ
+0.2841
rank correlation coefficient
P-value
0.0029
two-tailed significance
Species
108
data points
Significance
P < 0.01
significant
PGLS ฮฒ
+0.200
phylogenetic generalized least squares
PGLS P-value
0.2510
TimeTree5 phylogeny + logโ‚โ‚€ body mass covariate
Pagel's ฮป
0.90
estimated phylogenetic signal
PGLS FDR
1.000
genome-wide corrected
The PGLS statistics above control for phylogenetic relatedness (TimeTree5 time-calibrated phylogeny, Pagel's ฮป estimated by maximum likelihood) and adult body mass. All correlations in LACA are descriptive, species-level associations intended for hypothesis generation; they are not evidence of convergent evolution, natural selection, or causation.
Interpretation: The expression of SIRT1 shows a weak positive correlation with maximum lifespan (ฯ = +0.2841). This association is statistically significant (P = 0.0029). Species with higher expression of this gene tend to have longer lifespans. Based on cross-species comparison of 108 species.

Expression vs. Maximum Lifespan

Rankโ€“Rank Plot (Spearman Basis)

Detailed Data (108 species)

# Species Common Name Expression Expr. Rank Max Lifespan (yr) Lifespan Rank
1 Acanthopagrus latus Yellowfin seabream 0.1078 41 15.0 43.5
2 Amphiprion ocellaris Ocellaris clownfish 0.0822 28 12.0 34.5
3 Amphiprion percula Orange clownfish 0.0005 1 30.0 80.5
4 Anabas testudineus Climbing perch 0.1005 36 8.0 19
5 Astyanax mexicanus Mexican tetra 0.0683 17 5.0 10.5
6 Atractosteus spatula Alligator gar 0.1363 56 50.0 102
7 Betta splendens Siamese fighting fish 0.2254 90 5.0 10.5
8 Carassius auratus Goldfish 0.1083 42 41.0 101
9 Channa argus Northern snakehead 0.0865 31 10.0 26.5
10 Chelmon rostratus Copperband butterflyfish 0.1588 63 10.0 26.5
11 Chiloscyllium plagiosum Whitespotted bamboo shark 0.0751 22 25.0 72.5
12 Ctenopharyngodon idella Grass carp 0.0554 13 21.0 64.5
13 Cyprinus carpio Common carp 0.0408 6 38.0 94
14 Danio rerio Zebrafish 0.0504 11 5.5 15
15 Echeneis naucrates Live sharksucker 0.0933 33 5.0 10.5
16 Epinephelus fuscoguttatus Brown-marbled grouper 0.0580 15 40.0 98.5
17 Epinephelus lanceolatus Giant grouper 0.0740 21 37.0 90.5
18 Erpetoichthys calabaricus Reedfish 0.0863 30 18.0 50.5
19 Esox lucius Northern pike 0.0693 18 30.0 80.5
20 Gambusia affinis Western mosquitofish 0.1753 67 3.0 1
21 Lates calcarifer Barramundi 0.0433 7 20.0 60.5
22 Mastacembelus armatus Zig-zag eel 0.0957 35 15.0 43.5
23 Mchenga conophoros Mchenga conophoros 0.1013 37 5.0 10.5
24 Megalobrama amblycephala Blunt snout bream 0.0435 8.5 15.0 43.5
25 Melanotaenia boesemani Boeseman's rainbowfish 0.0340 4 8.0 19
26 Micropterus salmoides Largemouth bass 0.0732 20 16.0 47
27 Misgurnus anguillicaudatus Pond loach 0.1199 47 10.0 26.5
28 Monopterus albus Asian swamp eel 0.0782 25 10.0 26.5
29 Oncorhynchus mykiss Rainbow trout 0.1507 59 11.0 30.5
30 Petromyzon marinus Sea lamprey 0.0284 3 9.0 22
31 Plectropomus leopardus Leopard coral trout 0.0527 12 18.0 50.5
32 Poecilia reticulata Guppy 0.0788 26 5.0 10.5
33 Polypterus senegalus Senegal bichir 0.0779 24 34.0 86
34 Protopterus annectens West african lungfish 1.0789 107 25.0 72.5
35 Salarias fasciatus Jewelled blenny 0.0854 29 4.0 4.5
36 Scleropages formosus Asian arowana 0.0435 8.5 20.0 60.5
37 Scophthalmus maximus Turbot 0.1335 54 25.0 72.5
38 Siniperca chuatsi Chinese perch 0.1232 49 9.0 22
39 Synchiropus splendidus Mandarinfish 0.0758 23 5.0 10.5
40 Tachysurus fulvidraco Yellow catfish 0.1885 70 8.0 19
41 Xiphophorus hellerii Green swordtail 0.1061 40 5.0 10.5
42 Xiphophorus maculatus Southern platyfish 0.1279 52 5.0 10.5
43 Ailuropoda melanoleuca Giant panda 0.1277 51 38.0 94
44 Canis latrans Coyote 0.1460 58 18.0 50.5
45 Canis lupus familiaris Domestic dog 0.0572 14 24.0 70
46 Felis catus Domestic cat 0.3643 99 38.0 94
47 Mustela putorius furo Domestic ferret 0.1682 65 14.0 39.5
48 Neovison vison American mink 0.1959 75 10.0 26.5
49 Paguma larvata Masked palm civet 0.2208 87 20.0 55.5
50 Panthera tigris altaica Siberian tiger 0.1146 44 26.0 75
51 Ambystoma mexicanum Axolotl 1.3896 108 20.0 60.5
52 Pleurodeles waltl Iberian ribbed newt 0.2683 98 20.0 60.5
53 Xenopus laevis African clawed frog 0.0233 2 30.0 80.5
54 Anas platyrhynchos Mallard 0.2050 77 29.0 77
55 Columba livia Domestic pigeon 0.3748 101 35.0 87
56 Coturnix japonica Japanese quail 0.1583 61 6.0 16.5
57 Gallus gallus Red junglefowl 0.2252 89 30.0 80.5
58 Lonchura striata domestica Society finch 0.1390 57 10.0 26.5
59 Meleagris gallopavo Wild turkey 0.2588 95 12.0 34.5
60 Melopsittacus undulatus Budgerigar 0.5530 106 21.0 64.5
61 Serinus canaria Atlantic canary 0.1195 46 22.0 67
62 Struthio camelus Common ostrich 0.2210 88 62.0 106
63 Taeniopygia guttata Zebra finch 0.1849 69 14.0 39.5
64 Anolis sagrei Brown anole 0.1058 39 6.0 16.5
65 Chrysemys picta Painted turtle 0.3697 100 61.0 105
66 Mauremys mutica Asian yellow pond turtle 0.4722 105 30.0 80.5
67 Mauremys reevesii Chinese pond turtle 0.2281 91 25.0 72.5
68 Pelodiscus sinensis Chinese softshell turtle 0.2378 93 30.0 80.5
69 Pogona vitticeps Central bearded dragon 0.4633 104 15.0 43.5
70 Trachemys scripta elegans Red-eared slider 0.2623 96 40.0 98.5
71 Aotus nancymaae Nancy ma's night monkey 0.2194 85 20.0 55.5
72 Callithrix jacchus Common marmoset 0.1922 74 16.5 48
73 Chlorocebus sabaeus Green monkey 0.1650 64 30.1 84
74 Gorilla gorilla Western gorilla 0.2051 78 60.3 104
75 Homo sapiens Human 0.2556 94 122.6 108
76 Macaca fascicularis Crab-eating macaque 0.2097 80 38.4 96
77 Macaca mulatta Rhesus macaque 0.2133 81 40.0 98.5
78 Macaca nemestrina Pig-tailed macaque 0.2152 82 37.0 89
79 Microcebus murinus Gray mouse lemur 0.0931 32 18.2 53
80 Otolemur garnettii Small-eared galago 0.1208 48 18.0 50.5
81 Pan paniscus Bonobo 0.0717 19 60.0 103
82 Pan troglodytes Common chimpanzee 0.2192 84 68.1 107
83 Papio anubis Olive baboon 0.1558 60 37.5 92
84 Papio hamadryas Hamadryas baboon 0.1345 55 35.6 88
85 Saimiri sciureus Common squirrel monkey 0.1981 76 31.0 85
86 Atelerix albiventris Four-toed hedgehog 0.1261 50 11.0 30.5
87 Dasypus novemcinctus Nine-banded armadillo 0.1178 45 20.0 60.5
88 Manis javanica Sunda pangolin 0.1110 43 13.0 38
89 Oryctolagus cuniculus European rabbit 0.1823 68 12.0 34.5
90 Tupaia belangeri Northern tree shrew 0.4185 103 12.0 34.5
91 Bos taurus Cattle 0.3902 102 22.0 67
92 Equus asinus Donkey 0.0945 34 40.0 98.5
93 Ovis aries Domestic sheep 0.1910 73 20.0 60.5
94 Sus scrofa Pig 0.1285 53 27.0 76
95 Vicugna pacos Alpaca 0.1724 66 23.0 69
96 Branchiostoma floridae Florida lancelet 0.0476 10 4.0 4.5
97 Cavia porcellus Guinea pig 0.1584 62 12.0 34.5
98 Chinchilla lanigera Long-tailed chinchilla 0.1886 71 20.0 55.5
99 Heterocephalus glaber Naked mole rat 0.2662 97 37.0 90.5
100 Mesocricetus auratus Golden hamster 0.0649 16 4.0 4.5
101 Mus musculus House mouse 0.0795 27 4.0 4.5
102 Rattus norvegicus Norway rat 0.0360 5 3.8 2
103 Urocitellus parryii Arctic ground squirrel 0.2289 92 9.0 22
104 Cynopterus sphinx Greater short-nosed fruit bat 0.2080 79 12.0 34.5
105 Myotis ricketti Rickett's big-footed bat 0.1897 72 20.0 55.5
106 Rhinolophus affinis Intermediate horseshoe bat 0.1034 38 15.0 43.5
107 Rhinolophus sinicus Chinese rufous horseshoe bat 0.2162 83 15.0 43.5
108 Rousettus leschenaultii Leschenault's rousette 0.2198 86 22.0 67