⚙ How is this computed? Methods: Cross-Species Comparison

Gene Longevity Correlation

Query the Spearman rank correlation between a gene's expression level and maximum lifespan across all LACA species in which the queried gene has a confidently mapped ortholog and detectable expression; the exact species set is reported with each result.

Accepts any standard HGNC gene symbol

Popular: TP53 SIRT1 FOXO3 TERT MTOR KLOTHO IGF1R SOD2 LMNA BECN1 PARP1 WRN

Analysis Result

WRN
Spearman ฯ
+0.2367
rank correlation coefficient
P-value
0.0282
two-tailed significance
Species
86
data points
Significance
P < 0.05
significant
PGLS ฮฒ
+0.025
phylogenetic generalized least squares
PGLS P-value
0.8311
TimeTree5 phylogeny + logโ‚โ‚€ body mass covariate
Pagel's ฮป
0.90
estimated phylogenetic signal
PGLS FDR
1.000
genome-wide corrected
The PGLS statistics above control for phylogenetic relatedness (TimeTree5 time-calibrated phylogeny, Pagel's ฮป estimated by maximum likelihood) and adult body mass. All correlations in LACA are descriptive, species-level associations intended for hypothesis generation; they are not evidence of convergent evolution, natural selection, or causation.
Interpretation: The expression of WRN shows a weak positive correlation with maximum lifespan (ฯ = +0.2367). This association is statistically significant (P = 0.0282). Species with higher expression of this gene tend to have longer lifespans. Based on cross-species comparison of 86 species.

Expression vs. Maximum Lifespan

Rankโ€“Rank Plot (Spearman Basis)

Detailed Data (86 species)

# Species Common Name Expression Expr. Rank Max Lifespan (yr) Lifespan Rank
1 Astyanax mexicanus Mexican tetra 0.0075 5 5.0 6.5
2 Atractosteus spatula Alligator gar 0.1884 30 50.0 80
3 Carassius auratus Goldfish 0.0811 11 41.0 79
4 Chiloscyllium plagiosum Whitespotted bamboo shark 0.2832 41 25.0 54
5 Ctenopharyngodon idella Grass carp 0.2344 35 21.0 46.5
6 Cyprinus carpio Common carp 0.1102 18 38.0 73
7 Danio rerio Zebrafish 0.0019 2 5.5 8
8 Erpetoichthys calabaricus Reedfish 0.2604 38 18.0 34
9 Esox lucius Northern pike 0.0812 12 30.0 61
10 Megalobrama amblycephala Blunt snout bream 0.1946 32 15.0 29.5
11 Misgurnus anguillicaudatus Pond loach 0.0731 9 10.0 16
12 Oncorhynchus mykiss Rainbow trout 0.1336 25 11.0 18.5
13 Petromyzon marinus Sea lamprey 0.0105 6 9.0 13.5
14 Polypterus senegalus Senegal bichir 0.4385 60 34.0 66
15 Protopterus annectens West african lungfish 0.2730 40 25.0 54
16 Scleropages formosus Asian arowana 0.1465 26 20.0 43.5
17 Tachysurus fulvidraco Yellow catfish 0.1183 19 8.0 11.5
18 Ailuropoda melanoleuca Giant panda 0.1246 22 38.0 73
19 Canis latrans Coyote 0.6961 80 18.0 34
20 Canis lupus familiaris Domestic dog 0.3723 54 24.0 52
21 Felis catus Domestic cat 0.7049 81 38.0 73
22 Mustela putorius furo Domestic ferret 0.2652 39 14.0 26.5
23 Neovison vison American mink 0.3472 48 10.0 16
24 Paguma larvata Masked palm civet 0.1944 31 20.0 39
25 Panthera tigris altaica Siberian tiger 0.7102 83 26.0 56
26 Ambystoma mexicanum Axolotl 0.0013 1 20.0 43.5
27 Pleurodeles waltl Iberian ribbed newt 0.0050 3 20.0 43.5
28 Xenopus laevis African clawed frog 0.0805 10 30.0 61
29 Anas platyrhynchos Mallard 0.4803 64 29.0 58
30 Columba livia Domestic pigeon 0.3514 51 35.0 67
31 Coturnix japonica Japanese quail 0.1676 29 6.0 9
32 Gallus gallus Red junglefowl 0.2082 33 30.0 61
33 Lonchura striata domestica Society finch 0.1261 23 10.0 16
34 Meleagris gallopavo Wild turkey 0.5640 68 12.0 22
35 Melopsittacus undulatus Budgerigar 0.4316 59 21.0 46.5
36 Serinus canaria Atlantic canary 0.2406 36 22.0 49
37 Struthio camelus Common ostrich 0.3574 53 62.0 84
38 Taeniopygia guttata Zebra finch 0.1302 24 14.0 26.5
39 Anolis carolinensis Green anole 0.1469 27 7.2 10
40 Chrysemys picta Painted turtle 0.3506 50 61.0 83
41 Mauremys mutica Asian yellow pond turtle 0.3741 55 30.0 61
42 Mauremys reevesii Chinese pond turtle 0.5714 70 25.0 54
43 Pelodiscus sinensis Chinese softshell turtle 0.3235 44 30.0 61
44 Pogona vitticeps Central bearded dragon 0.0985 16 15.0 29.5
45 Trachemys scripta elegans Red-eared slider 0.4116 57 40.0 77
46 Aotus nancymaae Nancy ma's night monkey 0.3492 49 20.0 39
47 Callithrix jacchus Common marmoset 0.6123 74 16.5 32
48 Chlorocebus sabaeus Green monkey 0.5095 66 30.1 64
49 Gorilla gorilla Western gorilla 0.5551 67 60.3 82
50 Homo sapiens Human 0.2966 42 122.6 86
51 Macaca fascicularis Crab-eating macaque 0.5928 71 38.4 75
52 Macaca mulatta Rhesus macaque 0.5688 69 40.0 77
53 Macaca nemestrina Pig-tailed macaque 0.7934 85 37.0 69
54 Microcebus murinus Gray mouse lemur 0.0835 13 18.2 36
55 Otolemur garnettii Small-eared galago 0.6544 77 18.0 34
56 Pan paniscus Bonobo 0.0979 15 60.0 81
57 Pan troglodytes Common chimpanzee 0.4260 58 68.1 85
58 Papio anubis Olive baboon 0.6560 78 37.5 71
59 Papio hamadryas Hamadryas baboon 0.4091 56 35.6 68
60 Saimiri sciureus Common squirrel monkey 0.6488 76 31.0 65
61 Atelerix albiventris Four-toed hedgehog 0.4437 61 11.0 18.5
62 Dasypus novemcinctus Nine-banded armadillo 0.7760 84 20.0 43.5
63 Manis javanica Sunda pangolin 0.2323 34 13.0 25
64 Monodelphis domestica Gray short-tailed opossum 0.3388 47 4.0 3.5
65 Oryctolagus cuniculus European rabbit 0.3366 46 12.0 22
66 Tupaia belangeri Northern tree shrew 0.6110 73 12.0 22
67 Bos taurus Cattle 0.0246 7 22.0 49
68 Equus asinus Donkey 0.1032 17 40.0 77
69 Sus scrofa Pig 0.0897 14 27.0 57
70 Vicugna pacos Alpaca 0.7061 82 23.0 51
71 Branchiostoma floridae Florida lancelet 0.3070 43 4.0 3.5
72 Cavia porcellus Guinea pig 0.3549 52 12.0 22
73 Chinchilla lanigera Long-tailed chinchilla 0.4649 63 20.0 39
74 Heterocephalus glaber Naked mole rat 0.4453 62 37.0 70
75 Mesocricetus auratus Golden hamster 0.0059 4 4.0 3.5
76 Mus musculus House mouse 0.1184 20 4.0 3.5
77 Peromyscus maniculatus Baird's deer mouse 0.1224 21 8.0 11.5
78 Peromyscus polionotus Oldfield mouse 0.1507 28 5.0 6.5
79 Rattus norvegicus Norway rat 0.2467 37 3.8 1
80 Spalax galili Galilee blind mole rat 0.0605 8 20.0 39
81 Urocitellus parryii Arctic ground squirrel 0.9466 86 9.0 13.5
82 Cynopterus sphinx Greater short-nosed fruit bat 0.6670 79 12.0 22
83 Myotis ricketti Rickett's big-footed bat 0.6289 75 20.0 39
84 Rhinolophus affinis Intermediate horseshoe bat 0.3247 45 15.0 29.5
85 Rhinolophus sinicus Chinese rufous horseshoe bat 0.5021 65 15.0 29.5
86 Rousettus leschenaultii Leschenault's rousette 0.6001 72 22.0 49