⚙ How is this computed? Methods: Cross-Species Comparison

Gene Longevity Correlation

Query the Spearman rank correlation between a gene's expression level and maximum lifespan across all LACA species in which the queried gene has a confidently mapped ortholog and detectable expression; the exact species set is reported with each result.

Accepts any standard HGNC gene symbol

Popular: TP53 SIRT1 FOXO3 TERT MTOR KLOTHO IGF1R SOD2 LMNA BECN1 PARP1 WRN

Analysis Result

MTOR
Spearman ฯ
-0.0462
rank correlation coefficient
P-value
0.6269
two-tailed significance
Species
113
data points
Significance
n.s.
not significant
PGLS ฮฒ
-0.074
phylogenetic generalized least squares
PGLS P-value
0.4303
TimeTree5 phylogeny + logโ‚โ‚€ body mass covariate
Pagel's ฮป
0.90
estimated phylogenetic signal
PGLS FDR
1.000
genome-wide corrected
The PGLS statistics above control for phylogenetic relatedness (TimeTree5 time-calibrated phylogeny, Pagel's ฮป estimated by maximum likelihood) and adult body mass. All correlations in LACA are descriptive, species-level associations intended for hypothesis generation; they are not evidence of convergent evolution, natural selection, or causation.
Interpretation: The expression of MTOR shows a negligible negative correlation with maximum lifespan (ฯ = -0.0462). However, this association is not statistically significant (P = 0.6269). Based on cross-species comparison of 113 species.

Expression vs. Maximum Lifespan

Rankโ€“Rank Plot (Spearman Basis)

Detailed Data (113 species)

# Species Common Name Expression Expr. Rank Max Lifespan (yr) Lifespan Rank
1 Acanthopagrus latus Yellowfin seabream 0.3847 72 15.0 47.5
2 Amphiprion ocellaris Ocellaris clownfish 0.3964 75 12.0 38.5
3 Amphiprion percula Orange clownfish 0.4540 80 30.0 86
4 Anabas testudineus Climbing perch 0.3798 70 8.0 21.5
5 Astyanax mexicanus Mexican tetra 0.0988 10 5.0 12
6 Atractosteus spatula Alligator gar 0.5633 96 50.0 107
7 Betta splendens Siamese fighting fish 0.2912 52 5.0 12
8 Carassius auratus Goldfish 0.3081 58 41.0 106
9 Channa argus Northern snakehead 0.5140 89 10.0 30
10 Chelmon rostratus Copperband butterflyfish 0.2870 51 10.0 30
11 Chiloscyllium plagiosum Whitespotted bamboo shark 0.5123 88 25.0 78.5
12 Ctenopharyngodon idella Grass carp 1.3902 113 21.0 70.5
13 Cyprinus carpio Common carp 0.5672 97 38.0 99
14 Danio rerio Zebrafish 0.0210 1 5.5 17
15 Echeneis naucrates Live sharksucker 0.5603 94 5.0 12
16 Epinephelus fuscoguttatus Brown-marbled grouper 0.2234 32 40.0 103.5
17 Epinephelus lanceolatus Giant grouper 0.3176 60 37.0 95.5
18 Erpetoichthys calabaricus Reedfish 0.2418 38 18.0 54.5
19 Esox lucius Northern pike 0.2971 56 30.0 86
20 Gambusia affinis Western mosquitofish 0.9435 110 3.0 2
21 Lates calcarifer Barramundi 0.3301 65 20.0 66
22 Mastacembelus armatus Zig-zag eel 0.3215 61 15.0 47.5
23 Mchenga conophoros Mchenga conophoros 0.4506 79 5.0 12
24 Megalobrama amblycephala Blunt snout bream 0.6319 103 15.0 47.5
25 Melanotaenia boesemani Boeseman's rainbowfish 0.6131 102 8.0 21.5
26 Micropterus salmoides Largemouth bass 0.5746 98 16.0 51
27 Misgurnus anguillicaudatus Pond loach 0.4751 83 10.0 30
28 Monopterus albus Asian swamp eel 0.2317 35 10.0 30
29 Oncorhynchus mykiss Rainbow trout 0.2553 40.5 11.0 34.5
30 Oryzias latipes Japanese medaka 0.0339 5 4.0 5.5
31 Petromyzon marinus Sea lamprey 0.0249 3 9.0 25
32 Plectropomus leopardus Leopard coral trout 0.3566 68 18.0 54.5
33 Poecilia reticulata Guppy 0.8098 109 5.0 12
34 Polypterus senegalus Senegal bichir 0.2254 34 34.0 91
35 Protopterus annectens West african lungfish 0.7561 105 25.0 78.5
36 Salarias fasciatus Jewelled blenny 0.3290 64 4.0 5.5
37 Scleropages formosus Asian arowana 0.2797 50 20.0 66
38 Scophthalmus maximus Turbot 0.5523 93 25.0 78.5
39 Siniperca chuatsi Chinese perch 0.4815 85 9.0 25
40 Synchiropus splendidus Mandarinfish 0.3360 66 5.0 12
41 Tachysurus fulvidraco Yellow catfish 0.5459 92 8.0 21.5
42 Tetraodon nigroviridis Green spotted puffer 0.1443 16 10.0 30
43 Xiphophorus hellerii Green swordtail 1.2162 111 5.0 12
44 Xiphophorus maculatus Southern platyfish 1.3362 112 5.0 12
45 Ailuropoda melanoleuca Giant panda 0.2553 40.5 38.0 99
46 Canis latrans Coyote 0.2739 47 18.0 54.5
47 Canis lupus familiaris Domestic dog 0.3872 74 24.0 76
48 Felis catus Domestic cat 0.2966 55 38.0 99
49 Mustela putorius furo Domestic ferret 0.2147 29 14.0 43.5
50 Neovison vison American mink 0.2187 30 10.0 30
51 Paguma larvata Masked palm civet 0.1359 15 20.0 60
52 Panthera tigris altaica Siberian tiger 0.2652 43 26.0 81
53 Ambystoma mexicanum Axolotl 0.5412 90 20.0 66
54 Pleurodeles waltl Iberian ribbed newt 0.3657 69 20.0 66
55 Xenopus tropicalis Western clawed frog 0.0247 2 20.0 66
56 Anas platyrhynchos Mallard 0.3553 67 29.0 83
57 Columba livia Domestic pigeon 0.3845 71 35.0 92
58 Coturnix japonica Japanese quail 0.2918 53 6.0 18
59 Gallus gallus Red junglefowl 0.3254 63 30.0 86
60 Lonchura striata domestica Society finch 0.1164 12 10.0 30
61 Meleagris gallopavo Wild turkey 0.4575 81 12.0 38.5
62 Melopsittacus undulatus Budgerigar 0.2704 46 21.0 70.5
63 Serinus canaria Atlantic canary 0.2779 49 22.0 73
64 Struthio camelus Common ostrich 0.3250 62 62.0 111
65 Taeniopygia guttata Zebra finch 0.2063 27 14.0 43.5
66 Anolis carolinensis Green anole 0.3148 59 7.2 19
67 Chrysemys picta Painted turtle 0.2424 39 61.0 110
68 Mauremys mutica Asian yellow pond turtle 0.1739 22 30.0 86
69 Mauremys reevesii Chinese pond turtle 0.1982 24 25.0 78.5
70 Pelodiscus sinensis Chinese softshell turtle 0.2699 45 30.0 86
71 Pogona vitticeps Central bearded dragon 0.1225 13 15.0 47.5
72 Trachemys scripta elegans Red-eared slider 0.2778 48 40.0 103.5
73 Aotus nancymaae Nancy ma's night monkey 0.7638 106 20.0 60
74 Callithrix jacchus Common marmoset 0.5616 95 16.5 52
75 Chlorocebus sabaeus Green monkey 0.2388 37 30.1 89
76 Gorilla gorilla Western gorilla 0.4947 87 60.3 109
77 Homo sapiens Human 0.2019 26 122.6 113
78 Macaca fascicularis Crab-eating macaque 0.3055 57 38.4 101
79 Macaca mulatta Rhesus macaque 0.2114 28 40.0 103.5
80 Macaca nemestrina Pig-tailed macaque 0.4793 84 37.0 94
81 Microcebus murinus Gray mouse lemur 0.0528 7 18.2 57
82 Otolemur garnettii Small-eared galago 0.5916 99 18.0 54.5
83 Pan paniscus Bonobo 0.1093 11 60.0 108
84 Pan troglodytes Common chimpanzee 0.4612 82 68.1 112
85 Papio anubis Olive baboon 0.4241 76 37.5 97
86 Papio hamadryas Hamadryas baboon 0.2188 31 35.6 93
87 Saimiri sciureus Common squirrel monkey 0.5434 91 31.0 90
88 Atelerix albiventris Four-toed hedgehog 0.4897 86 11.0 34.5
89 Dasypus novemcinctus Nine-banded armadillo 0.7146 104 20.0 66
90 Manis javanica Sunda pangolin 0.2358 36 13.0 42
91 Oryctolagus cuniculus European rabbit 0.4337 77 12.0 38.5
92 Tupaia belangeri Northern tree shrew 0.7982 108 12.0 38.5
93 Bos taurus Cattle 0.0847 8 22.0 73
94 Equus asinus Donkey 0.1587 20 40.0 103.5
95 Ovis aries Domestic sheep 0.2236 33 20.0 66
96 Sus scrofa Pig 0.0961 9 27.0 82
97 Vicugna pacos Alpaca 0.2693 44 23.0 75
98 Ciona savignyi Pacific transparent sea squirt 0.7666 107 1.0 1
99 Cavia porcellus Guinea pig 0.1704 21 12.0 38.5
100 Chinchilla lanigera Long-tailed chinchilla 0.4456 78 20.0 60
101 Heterocephalus glaber Naked mole rat 0.2012 25 37.0 95.5
102 Mesocricetus auratus Golden hamster 0.0271 4 4.0 5.5
103 Mus musculus House mouse 0.1458 17 4.0 5.5
104 Peromyscus maniculatus Baird's deer mouse 0.1497 18 8.0 21.5
105 Peromyscus polionotus Oldfield mouse 0.1579 19 5.0 12
106 Rattus norvegicus Norway rat 0.1740 23 3.8 3
107 Spalax galili Galilee blind mole rat 0.0509 6 20.0 60
108 Urocitellus parryii Arctic ground squirrel 0.6031 101 9.0 25
109 Cynopterus sphinx Greater short-nosed fruit bat 0.2605 42 12.0 38.5
110 Myotis ricketti Rickett's big-footed bat 0.5968 100 20.0 60
111 Rhinolophus affinis Intermediate horseshoe bat 0.1287 14 15.0 47.5
112 Rhinolophus sinicus Chinese rufous horseshoe bat 0.3855 73 15.0 47.5
113 Rousettus leschenaultii Leschenault's rousette 0.2929 54 22.0 73