⚙ How is this computed? Methods: Cross-Species Comparison

Gene Longevity Correlation

Query the Spearman rank correlation between a gene's expression level and maximum lifespan across all LACA species in which the queried gene has a confidently mapped ortholog and detectable expression; the exact species set is reported with each result.

Accepts any standard HGNC gene symbol

Popular: TP53 SIRT1 FOXO3 TERT MTOR KLOTHO IGF1R SOD2 LMNA BECN1 PARP1 WRN

Analysis Result

IGF1R
Spearman ฯ
+0.2700
rank correlation coefficient
P-value
0.0075
two-tailed significance
Species
97
data points
Significance
P < 0.01
significant
PGLS ฮฒ
+0.016
phylogenetic generalized least squares
PGLS P-value
0.7452
TimeTree5 phylogeny + logโ‚โ‚€ body mass covariate
Pagel's ฮป
0.85
estimated phylogenetic signal
PGLS FDR
1.000
genome-wide corrected
The PGLS statistics above control for phylogenetic relatedness (TimeTree5 time-calibrated phylogeny, Pagel's ฮป estimated by maximum likelihood) and adult body mass. All correlations in LACA are descriptive, species-level associations intended for hypothesis generation; they are not evidence of convergent evolution, natural selection, or causation.
Interpretation: The expression of IGF1R shows a weak positive correlation with maximum lifespan (ฯ = +0.2700). This association is statistically significant (P = 0.0075). Species with higher expression of this gene tend to have longer lifespans. Based on cross-species comparison of 97 species.

Expression vs. Maximum Lifespan

Rankโ€“Rank Plot (Spearman Basis)

Detailed Data (97 species)

# Species Common Name Expression Expr. Rank Max Lifespan (yr) Lifespan Rank
1 Acanthopagrus latus Yellowfin seabream 0.3719 20 15.0 37.5
2 Amphiprion ocellaris Ocellaris clownfish 0.8497 53 12.0 29.5
3 Amphiprion percula Orange clownfish 0.5158 28 30.0 73.5
4 Atractosteus spatula Alligator gar 0.8717 56 50.0 91
5 Betta splendens Siamese fighting fish 0.4891 25 5.0 8.5
6 Chelmon rostratus Copperband butterflyfish 0.4826 24 10.0 23
7 Chiloscyllium plagiosum Whitespotted bamboo shark 0.4052 23 25.0 65.5
8 Ctenopharyngodon idella Grass carp 0.9250 61 21.0 57.5
9 Danio rerio Zebrafish 0.0068 1 5.5 12
10 Echeneis naucrates Live sharksucker 0.7265 43 5.0 8.5
11 Epinephelus fuscoguttatus Brown-marbled grouper 0.4932 27 40.0 89
12 Erpetoichthys calabaricus Reedfish 1.9231 96 18.0 43.5
13 Esox lucius Northern pike 0.8643 55 30.0 73.5
14 Gasterosteus aculeatus Three-spined stickleback 0.0183 3.5 8.0 16.5
15 Lates calcarifer Barramundi 0.8238 50 20.0 53.5
16 Melanotaenia boesemani Boeseman's rainbowfish 0.5667 32 8.0 16.5
17 Micropterus salmoides Largemouth bass 0.2986 17 16.0 40
18 Monopterus albus Asian swamp eel 0.8309 51 10.0 23
19 Plectropomus leopardus Leopard coral trout 0.6732 39 18.0 43.5
20 Poecilia reticulata Guppy 1.2496 75 5.0 8.5
21 Polypterus senegalus Senegal bichir 1.5145 93 34.0 79
22 Protopterus annectens West african lungfish 1.2555 76 25.0 65.5
23 Salarias fasciatus Jewelled blenny 0.3353 18 4.0 3.5
24 Scleropages formosus Asian arowana 0.8349 52 20.0 53.5
25 Scophthalmus maximus Turbot 0.7388 44 25.0 65.5
26 Siniperca chuatsi Chinese perch 0.7433 45 9.0 19.5
27 Synchiropus splendidus Mandarinfish 0.1882 9 5.0 8.5
28 Tachysurus fulvidraco Yellow catfish 0.6952 41 8.0 16.5
29 Tetraodon nigroviridis Green spotted puffer 0.7592 48 10.0 23
30 Xiphophorus maculatus Southern platyfish 0.4918 26 5.0 8.5
31 Ailuropoda melanoleuca Giant panda 0.5535 31 38.0 85.5
32 Canis latrans Coyote 1.3285 83 18.0 43.5
33 Canis lupus familiaris Domestic dog 0.8542 54 24.0 63
34 Felis catus Domestic cat 1.3689 87 38.0 85.5
35 Mustela putorius furo Domestic ferret 0.9182 60 14.0 34.5
36 Neovison vison American mink 0.7530 47 10.0 23
37 Panthera tigris altaica Siberian tiger 0.1787 8 26.0 68
38 Ambystoma mexicanum Axolotl 1.5166 94 20.0 53.5
39 Pleurodeles waltl Iberian ribbed newt 0.8908 58 20.0 53.5
40 Xenopus laevis African clawed frog 0.0083 2 30.0 73.5
41 Anas platyrhynchos Mallard 1.3441 86 29.0 70
42 Columba livia Domestic pigeon 1.2207 73 35.0 80
43 Coturnix japonica Japanese quail 0.6613 38 6.0 13
44 Gallus gallus Red junglefowl 0.8918 59 30.0 73.5
45 Lonchura striata domestica Society finch 0.2750 14 10.0 23
46 Meleagris gallopavo Wild turkey 1.0234 66 12.0 29.5
47 Melopsittacus undulatus Budgerigar 1.0048 65 21.0 57.5
48 Serinus canaria Atlantic canary 1.2560 77 22.0 60
49 Struthio camelus Common ostrich 1.2927 78 62.0 95
50 Taeniopygia guttata Zebra finch 0.8719 57 14.0 34.5
51 Anolis carolinensis Green anole 0.5834 33 7.2 14
52 Chrysemys picta Painted turtle 1.3826 89 61.0 94
53 Mauremys mutica Asian yellow pond turtle 1.2451 74 30.0 73.5
54 Mauremys reevesii Chinese pond turtle 1.4501 91 25.0 65.5
55 Pelodiscus sinensis Chinese softshell turtle 0.9912 64 30.0 73.5
56 Pogona vitticeps Central bearded dragon 0.3775 21 15.0 37.5
57 Aotus nancymaae Nancy ma's night monkey 1.3775 88 20.0 48.5
58 Callithrix jacchus Common marmoset 1.3419 85 16.5 41
59 Chlorocebus sabaeus Green monkey 0.6135 35 30.1 77
60 Gorilla gorilla Western gorilla 1.1040 67 60.3 93
61 Homo sapiens Human 0.6943 40 122.6 97
62 Macaca fascicularis Crab-eating macaque 0.5926 34 38.4 87
63 Macaca mulatta Rhesus macaque 0.6325 37 40.0 89
64 Macaca nemestrina Pig-tailed macaque 1.2938 79 37.0 82
65 Microcebus murinus Gray mouse lemur 0.1448 6 18.2 46
66 Otolemur garnettii Small-eared galago 1.1062 68 18.0 43.5
67 Pan paniscus Bonobo 0.2935 16 60.0 92
68 Pan troglodytes Common chimpanzee 1.2014 72 68.1 96
69 Papio anubis Olive baboon 1.1652 71 37.5 84
70 Papio hamadryas Hamadryas baboon 0.5458 30 35.6 81
71 Saimiri sciureus Common squirrel monkey 1.3134 81 31.0 78
72 Atelerix albiventris Four-toed hedgehog 1.1134 69 11.0 26
73 Dasypus novemcinctus Nine-banded armadillo 1.1361 70 20.0 53.5
74 Manis javanica Sunda pangolin 2.2380 97 13.0 33
75 Monodelphis domestica Gray short-tailed opossum 0.6196 36 4.0 3.5
76 Oryctolagus cuniculus European rabbit 0.7830 49 12.0 29.5
77 Tupaia belangeri Northern tree shrew 1.4024 90 12.0 29.5
78 Bos taurus Cattle 0.2610 13 22.0 60
79 Equus asinus Donkey 0.2592 12 40.0 89
80 Ovis aries Domestic sheep 1.4797 92 20.0 53.5
81 Sus scrofa Pig 0.1515 7 27.0 69
82 Vicugna pacos Alpaca 1.3025 80 23.0 62
83 Cavia porcellus Guinea pig 0.3460 19 12.0 29.5
84 Chinchilla lanigera Long-tailed chinchilla 0.7125 42 20.0 48.5
85 Heterocephalus glaber Naked mole rat 0.9284 62 37.0 83
86 Mesocricetus auratus Golden hamster 0.2861 15 4.0 3.5
87 Mus musculus House mouse 0.3822 22 4.0 3.5
88 Peromyscus maniculatus Baird's deer mouse 0.2459 11 8.0 16.5
89 Peromyscus polionotus Oldfield mouse 0.2244 10 5.0 8.5
90 Rattus norvegicus Norway rat 0.5423 29 3.8 1
91 Spalax galili Galilee blind mole rat 0.0183 3.5 20.0 48.5
92 Urocitellus parryii Arctic ground squirrel 1.5456 95 9.0 19.5
93 Cynopterus sphinx Greater short-nosed fruit bat 1.3160 82 12.0 29.5
94 Myotis ricketti Rickett's big-footed bat 0.7472 46 20.0 48.5
95 Rhinolophus affinis Intermediate horseshoe bat 0.0187 5 15.0 37.5
96 Rhinolophus sinicus Chinese rufous horseshoe bat 0.9325 63 15.0 37.5
97 Rousettus leschenaultii Leschenault's rousette 1.3343 84 22.0 60