⚙ How is this computed? Methods: Cross-Species Comparison

Gene Longevity Correlation

Query the Spearman rank correlation between a gene's expression level and maximum lifespan across all LACA species in which the queried gene has a confidently mapped ortholog and detectable expression; the exact species set is reported with each result.

Accepts any standard HGNC gene symbol

Popular: TP53 SIRT1 FOXO3 TERT MTOR KLOTHO IGF1R SOD2 LMNA BECN1 PARP1 WRN

Analysis Result

SOD2
Spearman ฯ
+0.0641
rank correlation coefficient
P-value
0.5059
two-tailed significance
Species
110
data points
Significance
n.s.
not significant
PGLS ฮฒ
+0.076
phylogenetic generalized least squares
PGLS P-value
0.4191
TimeTree5 phylogeny + logโ‚โ‚€ body mass covariate
Pagel's ฮป
0.90
estimated phylogenetic signal
PGLS FDR
1.000
genome-wide corrected
The PGLS statistics above control for phylogenetic relatedness (TimeTree5 time-calibrated phylogeny, Pagel's ฮป estimated by maximum likelihood) and adult body mass. All correlations in LACA are descriptive, species-level associations intended for hypothesis generation; they are not evidence of convergent evolution, natural selection, or causation.
Interpretation: The expression of SOD2 shows a negligible positive correlation with maximum lifespan (ฯ = +0.0641). However, this association is not statistically significant (P = 0.5059). Based on cross-species comparison of 110 species.

Expression vs. Maximum Lifespan

Rankโ€“Rank Plot (Spearman Basis)

Detailed Data (110 species)

# Species Common Name Expression Expr. Rank Max Lifespan (yr) Lifespan Rank
1 Acanthopagrus latus Yellowfin seabream 0.0271 10 15.0 49
2 Amphiprion ocellaris Ocellaris clownfish 0.1055 56 12.0 41.5
3 Amphiprion percula Orange clownfish 0.0482 29 30.0 84.5
4 Anabas testudineus Climbing perch 0.0301 13 8.0 24
5 Astyanax mexicanus Mexican tetra 0.4309 101 5.0 14
6 Atractosteus spatula Alligator gar 0.0269 9 50.0 104
7 Betta splendens Siamese fighting fish 0.0792 49 5.0 14
8 Channa argus Northern snakehead 0.0671 41 10.0 33
9 Chelmon rostratus Copperband butterflyfish 0.0640 39 10.0 33
10 Chiloscyllium plagiosum Whitespotted bamboo shark 0.0852 53 25.0 78.5
11 Ctenopharyngodon idella Grass carp 0.0748 45 21.0 70.5
12 Cyprinus carpio Common carp 0.0219 6 38.0 97
13 Danio rerio Zebrafish 0.2791 90 5.5 19
14 Echeneis naucrates Live sharksucker 0.2368 86 5.0 14
15 Epinephelus fuscoguttatus Brown-marbled grouper 0.0229 7 40.0 101.5
16 Epinephelus lanceolatus Giant grouper 0.0294 12 37.0 93.5
17 Erpetoichthys calabaricus Reedfish 0.0439 28 18.0 55.5
18 Esox lucius Northern pike 0.0303 15 30.0 84.5
19 Gambusia affinis Western mosquitofish 0.0232 8 3.0 2
20 Gasterosteus aculeatus Three-spined stickleback 0.1217 61.5 8.0 24
21 Lates calcarifer Barramundi 0.1163 60 20.0 66
22 Mastacembelus armatus Zig-zag eel 0.0372 23 15.0 49
23 Mchenga conophoros Mchenga conophoros 0.0174 4 5.0 14
24 Megalobrama amblycephala Blunt snout bream 0.1916 79 15.0 49
25 Melanotaenia boesemani Boeseman's rainbowfish 0.0279 11 8.0 24
26 Micropterus salmoides Largemouth bass 0.0302 14 16.0 52
27 Misgurnus anguillicaudatus Pond loach 0.0345 19 10.0 33
28 Monopterus albus Asian swamp eel 0.0421 26 10.0 33
29 Oncorhynchus mykiss Rainbow trout 0.0573 33 11.0 37.5
30 Oryzias latipes Japanese medaka 0.1296 66 4.0 6.5
31 Petromyzon marinus Sea lamprey 0.3974 97 9.0 28
32 Plectropomus leopardus Leopard coral trout 0.1617 75 18.0 55.5
33 Poecilia reticulata Guppy 0.0135 1 5.0 14
34 Polypterus senegalus Senegal bichir 0.0802 51 34.0 89
35 Protopterus annectens West african lungfish 0.1217 61.5 25.0 78.5
36 Salarias fasciatus Jewelled blenny 0.0593 34 4.0 6.5
37 Scleropages formosus Asian arowana 0.0502 31 20.0 66
38 Scophthalmus maximus Turbot 0.0750 46.5 25.0 78.5
39 Siniperca chuatsi Chinese perch 0.0334 18 9.0 28
40 Synchiropus splendidus Mandarinfish 0.0395 25 5.0 14
41 Tachysurus fulvidraco Yellow catfish 0.0367 22 8.0 24
42 Tetraodon nigroviridis Green spotted puffer 0.0200 5 10.0 33
43 Xiphophorus hellerii Green swordtail 0.0150 3 5.0 14
44 Xiphophorus maculatus Southern platyfish 0.0430 27 5.0 14
45 Ailuropoda melanoleuca Giant panda 0.4630 104 38.0 97
46 Canis latrans Coyote 0.3082 94 18.0 55.5
47 Canis lupus familiaris Domestic dog 0.2240 83 24.0 76
48 Felis catus Domestic cat 0.1983 82 38.0 97
49 Mustela putorius furo Domestic ferret 0.4414 102 14.0 45.5
50 Neovison vison American mink 0.5632 105 10.0 33
51 Ambystoma mexicanum Axolotl 0.0615 36 20.0 66
52 Pleurodeles waltl Iberian ribbed newt 0.1968 81 20.0 66
53 Xenopus tropicalis Western clawed frog 0.0359 20 20.0 66
54 Anas platyrhynchos Mallard 0.1324 68 29.0 82
55 Columba livia Domestic pigeon 0.0801 50 35.0 90
56 Coturnix japonica Japanese quail 0.0498 30 6.0 20
57 Lonchura striata domestica Society finch 0.4010 99 10.0 33
58 Meleagris gallopavo Wild turkey 0.1662 76 12.0 41.5
59 Melopsittacus undulatus Budgerigar 0.0629 37 21.0 70.5
60 Serinus canaria Atlantic canary 0.1785 78 22.0 73
61 Struthio camelus Common ostrich 0.1478 72 62.0 108
62 Taeniopygia guttata Zebra finch 0.3729 96 14.0 45.5
63 Anolis carolinensis Green anole 0.0718 43 7.2 21
64 Chrysemys picta Painted turtle 0.0658 40 61.0 107
65 Mauremys mutica Asian yellow pond turtle 0.0753 48 30.0 84.5
66 Mauremys reevesii Chinese pond turtle 0.0750 46.5 25.0 78.5
67 Pelodiscus sinensis Chinese softshell turtle 0.0360 21 30.0 84.5
68 Trachemys scripta elegans Red-eared slider 0.0631 38 40.0 101.5
69 Aotus nancymaae Nancy ma's night monkey 0.1390 71 20.0 60.5
70 Callithrix jacchus Common marmoset 0.0381 24 16.5 53
71 Chlorocebus sabaeus Green monkey 0.4183 100 30.1 87
72 Gorilla gorilla Western gorilla 0.2410 88 60.3 106
73 Homo sapiens Human 1.0550 108 122.6 110
74 Macaca fascicularis Crab-eating macaque 0.2852 93 38.4 99
75 Macaca mulatta Rhesus macaque 0.4428 103 40.0 101.5
76 Macaca nemestrina Pig-tailed macaque 0.1302 67 37.0 92
77 Microcebus murinus Gray mouse lemur 1.2571 109 18.2 58
78 Otolemur garnettii Small-eared galago 0.1570 73 18.0 55.5
79 Pan paniscus Bonobo 0.0959 55 60.0 105
80 Pan troglodytes Common chimpanzee 0.0319 16 68.1 109
81 Papio anubis Olive baboon 0.1243 63 37.5 95
82 Papio hamadryas Hamadryas baboon 0.1924 80 35.6 91
83 Saimiri sciureus Common squirrel monkey 0.1065 57 31.0 88
84 Atelerix albiventris Four-toed hedgehog 0.1294 65 11.0 37.5
85 Dasypus novemcinctus Nine-banded armadillo 0.0956 54 20.0 66
86 Monodelphis domestica Gray short-tailed opossum 0.2794 91 4.0 6.5
87 Oryctolagus cuniculus European rabbit 0.1375 70 12.0 41.5
88 Tupaia belangeri Northern tree shrew 0.1676 77 12.0 41.5
89 Bos taurus Cattle 0.0827 52 22.0 73
90 Equus asinus Donkey 0.3537 95 40.0 101.5
91 Ovis aries Domestic sheep 0.0597 35 20.0 66
92 Sus scrofa Pig 0.1571 74 27.0 81
93 Vicugna pacos Alpaca 0.0327 17 23.0 75
94 Branchiostoma floridae Florida lancelet 0.2340 84 4.0 6.5
95 Ciona savignyi Pacific transparent sea squirt 1.3378 110 1.0 1
96 Cavia porcellus Guinea pig 0.2812 92 12.0 41.5
97 Chinchilla lanigera Long-tailed chinchilla 0.2402 87 20.0 60.5
98 Heterocephalus glaber Naked mole rat 0.2518 89 37.0 93.5
99 Mesocricetus auratus Golden hamster 0.0137 2 4.0 6.5
100 Mus musculus House mouse 0.0516 32 4.0 6.5
101 Peromyscus maniculatus Baird's deer mouse 0.7297 106 8.0 24
102 Peromyscus polionotus Oldfield mouse 0.8065 107 5.0 14
103 Rattus norvegicus Norway rat 0.4006 98 3.8 3
104 Spalax galili Galilee blind mole rat 0.1369 69 20.0 60.5
105 Urocitellus parryii Arctic ground squirrel 0.0715 42 9.0 28
106 Cynopterus sphinx Greater short-nosed fruit bat 0.1159 59 12.0 41.5
107 Myotis ricketti Rickett's big-footed bat 0.1138 58 20.0 60.5
108 Rhinolophus affinis Intermediate horseshoe bat 0.1276 64 15.0 49
109 Rhinolophus sinicus Chinese rufous horseshoe bat 0.2365 85 15.0 49
110 Rousettus leschenaultii Leschenault's rousette 0.0730 44 22.0 73