⚙ How is this computed? Methods: Cross-Species Comparison

Gene Longevity Correlation

Query the Spearman rank correlation between a gene's expression level and maximum lifespan across all LACA species in which the queried gene has a confidently mapped ortholog and detectable expression; the exact species set is reported with each result.

Accepts any standard HGNC gene symbol

Popular: TP53 SIRT1 FOXO3 TERT MTOR KLOTHO IGF1R SOD2 LMNA BECN1 PARP1 WRN

Analysis Result

LMNA
Spearman ฯ
+0.1245
rank correlation coefficient
P-value
0.2013
two-tailed significance
Species
107
data points
Significance
n.s.
not significant
PGLS ฮฒ
+0.080
phylogenetic generalized least squares
PGLS P-value
0.4953
TimeTree5 phylogeny + logโ‚โ‚€ body mass covariate
Pagel's ฮป
0.90
estimated phylogenetic signal
PGLS FDR
1.000
genome-wide corrected
The PGLS statistics above control for phylogenetic relatedness (TimeTree5 time-calibrated phylogeny, Pagel's ฮป estimated by maximum likelihood) and adult body mass. All correlations in LACA are descriptive, species-level associations intended for hypothesis generation; they are not evidence of convergent evolution, natural selection, or causation.
Interpretation: The expression of LMNA shows a negligible positive correlation with maximum lifespan (ฯ = +0.1245). However, this association is not statistically significant (P = 0.2013). Based on cross-species comparison of 107 species.

Expression vs. Maximum Lifespan

Rankโ€“Rank Plot (Spearman Basis)

Detailed Data (107 species)

# Species Common Name Expression Expr. Rank Max Lifespan (yr) Lifespan Rank
1 Acanthopagrus latus Yellowfin seabream 0.1934 71 15.0 44.5
2 Amphiprion ocellaris Ocellaris clownfish 0.1272 54 12.0 36
3 Amphiprion percula Orange clownfish 0.1784 67 30.0 80.5
4 Anabas testudineus Climbing perch 0.1040 43 8.0 20.5
5 Astyanax mexicanus Mexican tetra 0.0721 27 5.0 11
6 Atractosteus spatula Alligator gar 0.1178 51 50.0 101
7 Betta splendens Siamese fighting fish 0.0825 29 5.0 11
8 Carassius auratus Goldfish 0.0588 21 41.0 100
9 Channa argus Northern snakehead 0.2013 74 10.0 28
10 Chelmon rostratus Copperband butterflyfish 0.1338 56 10.0 28
11 Chiloscyllium plagiosum Whitespotted bamboo shark 0.0245 11 25.0 73.5
12 Ctenopharyngodon idella Grass carp 0.0220 9 21.0 65.5
13 Cyprinus carpio Common carp 0.0288 13 38.0 93
14 Danio rerio Zebrafish 0.0190 7 5.5 16
15 Echeneis naucrates Live sharksucker 0.2648 87 5.0 11
16 Epinephelus fuscoguttatus Brown-marbled grouper 0.0966 36 40.0 97.5
17 Epinephelus lanceolatus Giant grouper 0.1505 63 37.0 89.5
18 Erpetoichthys calabaricus Reedfish 0.0937 34 18.0 51.5
19 Esox lucius Northern pike 0.2237 78 30.0 80.5
20 Gambusia affinis Western mosquitofish 0.1237 52 3.0 1
21 Lates calcarifer Barramundi 0.1479 62 20.0 61.5
22 Mastacembelus armatus Zig-zag eel 0.2925 89 15.0 44.5
23 Mchenga conophoros Mchenga conophoros 0.3562 98 5.0 11
24 Megalobrama amblycephala Blunt snout bream 0.0262 12 15.0 44.5
25 Melanotaenia boesemani Boeseman's rainbowfish 0.2151 77 8.0 20.5
26 Micropterus salmoides Largemouth bass 0.1016 39.5 16.0 48
27 Misgurnus anguillicaudatus Pond loach 0.1269 53 10.0 28
28 Monopterus albus Asian swamp eel 0.2292 80 10.0 28
29 Oncorhynchus mykiss Rainbow trout 0.0204 8 11.0 32.5
30 Plectropomus leopardus Leopard coral trout 0.1402 59 18.0 51.5
31 Poecilia reticulata Guppy 0.0748 28 5.0 11
32 Polypterus senegalus Senegal bichir 0.2319 81 34.0 85
33 Protopterus annectens West african lungfish 0.0554 20 25.0 73.5
34 Salarias fasciatus Jewelled blenny 0.0130 4 4.0 4.5
35 Scleropages formosus Asian arowana 0.0473 19 20.0 61.5
36 Scophthalmus maximus Turbot 0.2446 84 25.0 73.5
37 Siniperca chuatsi Chinese perch 0.1901 69 9.0 23.5
38 Synchiropus splendidus Mandarinfish 0.0023 3 5.0 11
39 Tachysurus fulvidraco Yellow catfish 0.0717 26 8.0 20.5
40 Tetraodon nigroviridis Green spotted puffer 0.1111 49 10.0 28
41 Xiphophorus hellerii Green swordtail 0.1128 50 5.0 11
42 Xiphophorus maculatus Southern platyfish 0.1406 60 5.0 11
43 Ailuropoda melanoleuca Giant panda 0.8755 106 38.0 93
44 Canis latrans Coyote 0.0864 32 18.0 51.5
45 Canis lupus familiaris Domestic dog 0.0356 15 24.0 71
46 Felis catus Domestic cat 0.1356 57 38.0 93
47 Mustela putorius furo Domestic ferret 0.2241 79 14.0 40.5
48 Neovison vison American mink 0.0591 22 10.0 28
49 Panthera tigris altaica Siberian tiger 0.2148 76 26.0 76
50 Ambystoma mexicanum Axolotl 0.0948 35 20.0 61.5
51 Pleurodeles waltl Iberian ribbed newt 0.2596 86 20.0 61.5
52 Anas platyrhynchos Mallard 0.1059 46 29.0 78
53 Columba livia Domestic pigeon 0.2426 83 35.0 86
54 Coturnix japonica Japanese quail 0.0159 6 6.0 17
55 Lonchura striata domestica Society finch 0.1074 47 10.0 28
56 Melopsittacus undulatus Budgerigar 0.2050 75 21.0 65.5
57 Serinus canaria Atlantic canary 0.0659 23 22.0 68
58 Struthio camelus Common ostrich 0.1731 66 62.0 105
59 Taeniopygia guttata Zebra finch 0.1019 41 14.0 40.5
60 Anolis carolinensis Green anole 0.0000 1.5 7.2 18
61 Chrysemys picta Painted turtle 0.0367 17 61.0 104
62 Mauremys mutica Asian yellow pond turtle 0.1562 64 30.0 80.5
63 Mauremys reevesii Chinese pond turtle 0.0858 31 25.0 73.5
64 Pelodiscus sinensis Chinese softshell turtle 0.1829 68 30.0 80.5
65 Pogona vitticeps Central bearded dragon 0.1717 65 15.0 44.5
66 Trachemys scripta elegans Red-eared slider 0.0973 37 40.0 97.5
67 Aotus nancymaae Nancy ma's night monkey 0.0907 33 20.0 56.5
68 Callithrix jacchus Common marmoset 0.1016 39.5 16.5 49
69 Chlorocebus sabaeus Green monkey 0.3108 91 30.1 83
70 Gorilla gorilla Western gorilla 0.1965 73 60.3 103
71 Homo sapiens Human 0.7284 105 122.6 107
72 Macaca fascicularis Crab-eating macaque 0.3404 96 38.4 95
73 Macaca mulatta Rhesus macaque 0.3359 95 40.0 97.5
74 Macaca nemestrina Pig-tailed macaque 0.0855 30 37.0 88
75 Microcebus murinus Gray mouse lemur 0.6704 104 18.2 54
76 Otolemur garnettii Small-eared galago 0.1050 44.5 18.0 51.5
77 Pan paniscus Bonobo 0.1931 70 60.0 102
78 Pan troglodytes Common chimpanzee 0.1956 72 68.1 106
79 Papio anubis Olive baboon 0.1050 44.5 37.5 91
80 Papio hamadryas Hamadryas baboon 0.3015 90 35.6 87
81 Saimiri sciureus Common squirrel monkey 0.1036 42 31.0 84
82 Atelerix albiventris Four-toed hedgehog 0.2585 85 11.0 32.5
83 Dasypus novemcinctus Nine-banded armadillo 0.0695 25 20.0 61.5
84 Manis javanica Sunda pangolin 0.3261 93 13.0 39
85 Monodelphis domestica Gray short-tailed opossum 0.1418 61 4.0 4.5
86 Oryctolagus cuniculus European rabbit 0.0359 16 12.0 36
87 Tupaia belangeri Northern tree shrew 0.0394 18 12.0 36
88 Bos taurus Cattle 0.9236 107 22.0 68
89 Equus asinus Donkey 0.3440 97 40.0 97.5
90 Ovis aries Domestic sheep 0.0157 5 20.0 61.5
91 Sus scrofa Pig 0.2674 88 27.0 77
92 Vicugna pacos Alpaca 0.0315 14 23.0 70
93 Cavia porcellus Guinea pig 0.3964 101 12.0 36
94 Chinchilla lanigera Long-tailed chinchilla 0.1110 48 20.0 56.5
95 Heterocephalus glaber Naked mole rat 0.3333 94 37.0 89.5
96 Mesocricetus auratus Golden hamster 0.0226 10 4.0 4.5
97 Mus musculus House mouse 0.3656 99 4.0 4.5
98 Peromyscus maniculatus Baird's deer mouse 0.3923 100 8.0 20.5
99 Peromyscus polionotus Oldfield mouse 0.4547 102 5.0 11
100 Rattus norvegicus Norway rat 0.4949 103 3.8 2
101 Spalax galili Galilee blind mole rat 0.0000 1.5 20.0 56.5
102 Urocitellus parryii Arctic ground squirrel 0.2384 82 9.0 23.5
103 Cynopterus sphinx Greater short-nosed fruit bat 0.3121 92 12.0 36
104 Myotis ricketti Rickett's big-footed bat 0.0996 38 20.0 56.5
105 Rhinolophus affinis Intermediate horseshoe bat 0.0677 24 15.0 44.5
106 Rhinolophus sinicus Chinese rufous horseshoe bat 0.1395 58 15.0 44.5
107 Rousettus leschenaultii Leschenault's rousette 0.1299 55 22.0 68