⚙ How is this computed? Methods: Cross-Species Comparison

Gene Longevity Correlation

Query the Spearman rank correlation between a gene's expression level and maximum lifespan across all LACA species in which the queried gene has a confidently mapped ortholog and detectable expression; the exact species set is reported with each result.

Accepts any standard HGNC gene symbol

Popular: TP53 SIRT1 FOXO3 TERT MTOR KLOTHO IGF1R SOD2 LMNA BECN1 PARP1 WRN

Analysis Result

TERT
Spearman ฯ
-0.1742
rank correlation coefficient
P-value
0.0799
two-tailed significance
Species
102
data points
Significance
n.s.
not significant
PGLS ฮฒ
+0.072
phylogenetic generalized least squares
PGLS P-value
0.7857
TimeTree5 phylogeny + logโ‚โ‚€ body mass covariate
Pagel's ฮป
0.90
estimated phylogenetic signal
PGLS FDR
1.000
genome-wide corrected
The PGLS statistics above control for phylogenetic relatedness (TimeTree5 time-calibrated phylogeny, Pagel's ฮป estimated by maximum likelihood) and adult body mass. All correlations in LACA are descriptive, species-level associations intended for hypothesis generation; they are not evidence of convergent evolution, natural selection, or causation.
Interpretation: The expression of TERT shows a negligible negative correlation with maximum lifespan (ฯ = -0.1742). However, this association is not statistically significant (P = 0.0799). Based on cross-species comparison of 102 species.

Expression vs. Maximum Lifespan

Rankโ€“Rank Plot (Spearman Basis)

Detailed Data (102 species)

# Species Common Name Expression Expr. Rank Max Lifespan (yr) Lifespan Rank
1 Acanthopagrus latus Yellowfin seabream 0.0460 70 15.0 42.5
2 Amphiprion ocellaris Ocellaris clownfish 0.1054 87 12.0 34.5
3 Amphiprion percula Orange clownfish 0.0989 85 30.0 75.5
4 Anabas testudineus Climbing perch 0.0168 49 8.0 18.5
5 Astyanax mexicanus Mexican tetra 0.0053 26 5.0 9
6 Betta splendens Siamese fighting fish 0.0514 74 5.0 9
7 Carassius auratus Goldfish 0.0005 2 41.0 96
8 Channa argus Northern snakehead 0.0107 40 10.0 27
9 Chelmon rostratus Copperband butterflyfish 0.0851 82 10.0 27
10 Chiloscyllium plagiosum Whitespotted bamboo shark 0.0313 65 25.0 67.5
11 Ctenopharyngodon idella Grass carp 0.0013 6.5 21.0 60.5
12 Cyprinus carpio Common carp 0.0057 28 38.0 89
13 Danio rerio Zebrafish 0.0185 53.5 5.5 14
14 Echeneis naucrates Live sharksucker 0.2291 97 5.0 9
15 Epinephelus fuscoguttatus Brown-marbled grouper 0.0242 58 40.0 93.5
16 Epinephelus lanceolatus Giant grouper 0.0304 61 37.0 85.5
17 Erpetoichthys calabaricus Reedfish 0.0524 75 18.0 48.5
18 Esox lucius Northern pike 0.0010 4.5 30.0 75.5
19 Gambusia affinis Western mosquitofish 0.0088 38 3.0 1
20 Lates calcarifer Barramundi 0.0173 50 20.0 57
21 Mastacembelus armatus Zig-zag eel 0.0292 60 15.0 42.5
22 Mchenga conophoros Mchenga conophoros 0.0082 34 5.0 9
23 Megalobrama amblycephala Blunt snout bream 0.0130 44 15.0 42.5
24 Melanotaenia boesemani Boeseman's rainbowfish 0.0507 73 8.0 18.5
25 Micropterus salmoides Largemouth bass 0.1411 92 16.0 46
26 Misgurnus anguillicaudatus Pond loach 0.0152 47 10.0 27
27 Monopterus albus Asian swamp eel 0.0185 53.5 10.0 27
28 Oncorhynchus mykiss Rainbow trout 0.0716 79 11.0 31.5
29 Petromyzon marinus Sea lamprey 0.0617 76 9.0 22
30 Plectropomus leopardus Leopard coral trout 0.1052 86 18.0 48.5
31 Poecilia reticulata Guppy 0.0145 46 5.0 9
32 Polypterus senegalus Senegal bichir 0.1057 88 34.0 81
33 Protopterus annectens West african lungfish 0.0316 66 25.0 67.5
34 Salarias fasciatus Jewelled blenny 0.0665 77 4.0 3.5
35 Scleropages formosus Asian arowana 0.0357 68 20.0 57
36 Scophthalmus maximus Turbot 0.0504 72 25.0 67.5
37 Siniperca chuatsi Chinese perch 0.0306 62.5 9.0 22
38 Synchiropus splendidus Mandarinfish 0.0166 48 5.0 9
39 Tachysurus fulvidraco Yellow catfish 0.0308 64 8.0 18.5
40 Tetraodon nigroviridis Green spotted puffer 0.1074 89 10.0 27
41 Xiphophorus hellerii Green swordtail 0.0016 11.5 5.0 9
42 Xiphophorus maculatus Southern platyfish 0.0322 67 5.0 9
43 Ailuropoda melanoleuca Giant panda 0.0023 14 38.0 89
44 Canis latrans Coyote 0.0762 81 18.0 48.5
45 Canis lupus familiaris Domestic dog 0.0682 78 24.0 65
46 Felis catus Domestic cat 0.0123 41 38.0 89
47 Mustela putorius furo Domestic ferret 0.0085 35 14.0 38.5
48 Neovison vison American mink 0.0126 43 10.0 27
49 Panthera tigris altaica Siberian tiger 0.0023 14 26.0 70
50 Ambystoma mexicanum Axolotl 0.0401 69 20.0 57
51 Xenopus laevis African clawed frog 0.0046 24 30.0 75.5
52 Anas platyrhynchos Mallard 0.1214 91 29.0 72
53 Columba livia Domestic pigeon 0.0179 52 35.0 82
54 Coturnix japonica Japanese quail 0.0196 56 6.0 15
55 Gallus gallus Red junglefowl 0.0306 62.5 30.0 75.5
56 Lonchura striata domestica Society finch 0.0254 59 10.0 27
57 Meleagris gallopavo Wild turkey 0.0188 55 12.0 34.5
58 Melopsittacus undulatus Budgerigar 0.3060 99 21.0 60.5
59 Serinus canaria Atlantic canary 0.2093 96 22.0 62.5
60 Struthio camelus Common ostrich 0.3014 98 62.0 100
61 Taeniopygia guttata Zebra finch 0.0752 80 14.0 38.5
62 Anolis carolinensis Green anole 0.0970 84 7.2 16
63 Chrysemys picta Painted turtle 0.4808 100 61.0 99
64 Mauremys mutica Asian yellow pond turtle 0.6009 101 30.0 75.5
65 Mauremys reevesii Chinese pond turtle 0.8802 102 25.0 67.5
66 Pelodiscus sinensis Chinese softshell turtle 0.1719 93 30.0 75.5
67 Pogona vitticeps Central bearded dragon 0.1182 90 15.0 42.5
68 Trachemys scripta elegans Red-eared slider 0.1780 95 40.0 93.5
69 Aotus nancymaae Nancy ma's night monkey 0.0014 8.5 20.0 53
70 Chlorocebus sabaeus Green monkey 0.0068 31 30.1 79
71 Gorilla gorilla Western gorilla 0.0013 6.5 60.3 98
72 Homo sapiens Human 0.0015 10 122.6 102
73 Macaca fascicularis Crab-eating macaque 0.0032 18.5 38.4 91
74 Macaca mulatta Rhesus macaque 0.0025 16 40.0 93.5
75 Macaca nemestrina Pig-tailed macaque 0.0058 29 37.0 84
76 Microcebus murinus Gray mouse lemur 0.0076 33 18.2 51
77 Otolemur garnettii Small-eared galago 0.0900 83 18.0 48.5
78 Pan paniscus Bonobo 0.0003 1 60.0 97
79 Pan troglodytes Common chimpanzee 0.0023 14 68.1 101
80 Papio anubis Olive baboon 0.0037 20 37.5 87
81 Papio hamadryas Hamadryas baboon 0.0014 8.5 35.6 83
82 Saimiri sciureus Common squirrel monkey 0.0087 36 31.0 80
83 Atelerix albiventris Four-toed hedgehog 0.0006 3 11.0 31.5
84 Dasypus novemcinctus Nine-banded armadillo 0.0029 17 20.0 57
85 Manis javanica Sunda pangolin 0.0176 51 13.0 37
86 Oryctolagus cuniculus European rabbit 0.1778 94 12.0 34.5
87 Bos taurus Cattle 0.0016 11.5 22.0 62.5
88 Equus asinus Donkey 0.0010 4.5 40.0 93.5
89 Ovis aries Domestic sheep 0.0047 25 20.0 57
90 Sus scrofa Pig 0.0042 21.5 27.0 71
91 Vicugna pacos Alpaca 0.0214 57 23.0 64
92 Chinchilla lanigera Long-tailed chinchilla 0.0056 27 20.0 53
93 Heterocephalus glaber Naked mole rat 0.0088 38 37.0 85.5
94 Mus musculus House mouse 0.0065 30 4.0 3.5
95 Peromyscus maniculatus Baird's deer mouse 0.0143 45 8.0 18.5
96 Peromyscus polionotus Oldfield mouse 0.0124 42 5.0 9
97 Rattus norvegicus Norway rat 0.0069 32 3.8 2
98 Urocitellus parryii Arctic ground squirrel 0.0042 21.5 9.0 22
99 Cynopterus sphinx Greater short-nosed fruit bat 0.0481 71 12.0 34.5
100 Myotis ricketti Rickett's big-footed bat 0.0044 23 20.0 53
101 Rhinolophus affinis Intermediate horseshoe bat 0.0088 38 15.0 42.5
102 Rhinolophus sinicus Chinese rufous horseshoe bat 0.0032 18.5 15.0 42.5