⚙ How is this computed? Methods: Cross-Species Comparison

Gene Longevity Correlation

Query the Spearman rank correlation between a gene's expression level and maximum lifespan across all LACA species in which the queried gene has a confidently mapped ortholog and detectable expression; the exact species set is reported with each result.

Accepts any standard HGNC gene symbol

Popular: TP53 SIRT1 FOXO3 TERT MTOR KLOTHO IGF1R SOD2 LMNA BECN1 PARP1 WRN

Analysis Result

KLOTHO
Spearman ฯ
+0.0968
rank correlation coefficient
P-value
0.3192
two-tailed significance
Species
108
data points
Significance
n.s.
not significant
PGLS ฮฒ
+0.709
phylogenetic generalized least squares
PGLS P-value
0.4186
TimeTree5 phylogeny + logโ‚โ‚€ body mass covariate
Pagel's ฮป
0.90
estimated phylogenetic signal
PGLS FDR
1.000
genome-wide corrected
The PGLS statistics above control for phylogenetic relatedness (TimeTree5 time-calibrated phylogeny, Pagel's ฮป estimated by maximum likelihood) and adult body mass. All correlations in LACA are descriptive, species-level associations intended for hypothesis generation; they are not evidence of convergent evolution, natural selection, or causation.
Interpretation: The expression of KLOTHO shows a negligible positive correlation with maximum lifespan (ฯ = +0.0968). However, this association is not statistically significant (P = 0.3192). Based on cross-species comparison of 108 species.

Expression vs. Maximum Lifespan

Rankโ€“Rank Plot (Spearman Basis)

Detailed Data (108 species)

# Species Common Name Expression Expr. Rank Max Lifespan (yr) Lifespan Rank
1 Acanthopagrus latus Yellowfin seabream 0.0086 51 15.0 44.5
2 Amphiprion ocellaris Ocellaris clownfish 0.0118 63 12.0 35.5
3 Amphiprion percula Orange clownfish 0.0277 79 30.0 80.5
4 Anabas testudineus Climbing perch 0.0025 19 8.0 19
5 Astyanax mexicanus Mexican tetra 0.0006 5 5.0 10
6 Atractosteus spatula Alligator gar 0.0022 17.5 50.0 102
7 Betta splendens Siamese fighting fish 0.0543 97 5.0 10
8 Carassius auratus Goldfish 0.0017 12.5 41.0 101
9 Channa argus Northern snakehead 0.0130 65 10.0 27
10 Chelmon rostratus Copperband butterflyfish 0.0019 14.5 10.0 27
11 Chiloscyllium plagiosum Whitespotted bamboo shark 0.0070 40.5 25.0 72.5
12 Ctenopharyngodon idella Grass carp 0.0010 7 21.0 64.5
13 Cyprinus carpio Common carp 0.0039 27 38.0 94
14 Danio rerio Zebrafish 0.0128 64 5.5 15
15 Echeneis naucrates Live sharksucker 0.0327 81 5.0 10
16 Epinephelus fuscoguttatus Brown-marbled grouper 0.0047 30 40.0 98.5
17 Epinephelus lanceolatus Giant grouper 0.0081 47 37.0 90.5
18 Erpetoichthys calabaricus Reedfish 0.0040 28.5 18.0 51.5
19 Esox lucius Northern pike 0.0194 70.5 30.0 80.5
20 Gambusia affinis Western mosquitofish 0.0029 23 3.0 1
21 Gasterosteus aculeatus Three-spined stickleback 0.0020 16 8.0 19
22 Lates calcarifer Barramundi 0.0057 35 20.0 60.5
23 Mastacembelus armatus Zig-zag eel 0.0048 31 15.0 44.5
24 Mchenga conophoros Mchenga conophoros 0.0094 55 5.0 10
25 Megalobrama amblycephala Blunt snout bream 0.0005 4 15.0 44.5
26 Melanotaenia boesemani Boeseman's rainbowfish 0.0069 38.5 8.0 19
27 Micropterus salmoides Largemouth bass 0.0082 48.5 16.0 48
28 Misgurnus anguillicaudatus Pond loach 0.0100 58 10.0 27
29 Monopterus albus Asian swamp eel 0.0395 85.5 10.0 27
30 Oncorhynchus mykiss Rainbow trout 0.0065 36 11.0 31.5
31 Plectropomus leopardus Leopard coral trout 0.0180 68 18.0 51.5
32 Poecilia reticulata Guppy 0.0101 59.5 5.0 10
33 Polypterus senegalus Senegal bichir 0.0102 61 34.0 86
34 Protopterus annectens West african lungfish 0.0435 90 25.0 72.5
35 Salarias fasciatus Jewelled blenny 0.0019 14.5 4.0 4
36 Scleropages formosus Asian arowana 0.0031 24 20.0 60.5
37 Scophthalmus maximus Turbot 0.0156 66.5 25.0 72.5
38 Siniperca chuatsi Chinese perch 0.0089 52 9.0 22.5
39 Synchiropus splendidus Mandarinfish 0.0250 74 5.0 10
40 Tachysurus fulvidraco Yellow catfish 0.0007 6 8.0 19
41 Tetraodon nigroviridis Green spotted puffer 0.1276 106 10.0 27
42 Xiphophorus hellerii Green swordtail 0.0017 12.5 5.0 10
43 Xiphophorus maculatus Southern platyfish 0.0012 9 5.0 10
44 Ailuropoda melanoleuca Giant panda 0.0002 2.5 38.0 94
45 Canis latrans Coyote 0.0224 73 18.0 51.5
46 Canis lupus familiaris Domestic dog 0.0191 69 24.0 70
47 Felis catus Domestic cat 0.0676 102 38.0 94
48 Mustela putorius furo Domestic ferret 0.0285 80 14.0 40.5
49 Neovison vison American mink 0.0110 62 10.0 27
50 Panthera tigris altaica Siberian tiger 0.0510 93.5 26.0 75
51 Ambystoma mexicanum Axolotl 0.0571 99 20.0 60.5
52 Pleurodeles waltl Iberian ribbed newt 0.1372 107 20.0 60.5
53 Xenopus laevis African clawed frog 0.0072 42.5 30.0 80.5
54 Anas platyrhynchos Mallard 0.0671 100 29.0 77
55 Columba livia Domestic pigeon 0.0699 103 35.0 87
56 Gallus gallus Red junglefowl 0.0775 104 30.0 80.5
57 Meleagris gallopavo Wild turkey 0.0673 101 12.0 35.5
58 Melopsittacus undulatus Budgerigar 0.0925 105 21.0 64.5
59 Serinus canaria Atlantic canary 0.0418 88 22.0 67
60 Struthio camelus Common ostrich 0.0467 91 62.0 106
61 Taeniopygia guttata Zebra finch 0.0261 75 14.0 40.5
62 Anolis carolinensis Green anole 0.0035 25 7.2 16
63 Chrysemys picta Painted turtle 0.0560 98 61.0 105
64 Mauremys mutica Asian yellow pond turtle 0.0509 92 30.0 80.5
65 Mauremys reevesii Chinese pond turtle 0.0510 93.5 25.0 72.5
66 Pelodiscus sinensis Chinese softshell turtle 0.0531 96 30.0 80.5
67 Pogona vitticeps Central bearded dragon 0.0091 53.5 15.0 44.5
68 Trachemys scripta elegans Red-eared slider 0.0382 84 40.0 98.5
69 Aotus nancymaae Nancy ma's night monkey 0.0069 38.5 20.0 56
70 Callithrix jacchus Common marmoset 0.0070 40.5 16.5 49
71 Chlorocebus sabaeus Green monkey 0.0101 59.5 30.1 84
72 Gorilla gorilla Western gorilla 0.0026 20.5 60.3 104
73 Homo sapiens Human 0.0194 70.5 122.6 108
74 Macaca fascicularis Crab-eating macaque 0.0223 72 38.4 96
75 Macaca mulatta Rhesus macaque 0.0082 48.5 40.0 98.5
76 Macaca nemestrina Pig-tailed macaque 0.0056 34 37.0 89
77 Microcebus murinus Gray mouse lemur 0.0013 10 18.2 54
78 Otolemur garnettii Small-eared galago 0.0072 42.5 18.0 51.5
79 Pan paniscus Bonobo 0.0011 8 60.0 103
80 Pan troglodytes Common chimpanzee 0.0027 22 68.1 107
81 Papio anubis Olive baboon 0.0040 28.5 37.5 92
82 Papio hamadryas Hamadryas baboon 0.0273 77 35.6 88
83 Saimiri sciureus Common squirrel monkey 0.0099 57 31.0 85
84 Atelerix albiventris Four-toed hedgehog 0.0395 85.5 11.0 31.5
85 Dasypus novemcinctus Nine-banded armadillo 0.0049 32 20.0 60.5
86 Manis javanica Sunda pangolin 0.0347 82 13.0 39
87 Monodelphis domestica Gray short-tailed opossum 0.0268 76 4.0 4
88 Oryctolagus cuniculus European rabbit 0.0523 95 12.0 35.5
89 Tupaia belangeri Northern tree shrew 0.0426 89 12.0 35.5
90 Bos taurus Cattle 0.0091 53.5 22.0 67
91 Equus asinus Donkey 0.1399 108 40.0 98.5
92 Ovis aries Domestic sheep 0.0036 26 20.0 60.5
93 Sus scrofa Pig 0.0075 44 27.0 76
94 Vicugna pacos Alpaca 0.0055 33 23.0 69
95 Cavia porcellus Guinea pig 0.0001 1 12.0 35.5
96 Chinchilla lanigera Long-tailed chinchilla 0.0068 37 20.0 56
97 Heterocephalus glaber Naked mole rat 0.0002 2.5 37.0 90.5
98 Ictidomys tridecemlineatus Thirteen-lined ground squirrel 0.0156 66.5 10.0 27
99 Mus musculus House mouse 0.0274 78 4.0 4
100 Peromyscus maniculatus Baird's deer mouse 0.0076 45 8.0 19
101 Peromyscus polionotus Oldfield mouse 0.0095 56 5.0 10
102 Rattus norvegicus Norway rat 0.0084 50 3.8 2
103 Urocitellus parryii Arctic ground squirrel 0.0014 11 9.0 22.5
104 Cynopterus sphinx Greater short-nosed fruit bat 0.0026 20.5 12.0 35.5
105 Myotis ricketti Rickett's big-footed bat 0.0078 46 20.0 56
106 Rhinolophus affinis Intermediate horseshoe bat 0.0354 83 15.0 44.5
107 Rhinolophus sinicus Chinese rufous horseshoe bat 0.0403 87 15.0 44.5
108 Rousettus leschenaultii Leschenault's rousette 0.0022 17.5 22.0 67