⚙ How is this computed? Methods: Cross-Species Comparison

Gene Longevity Correlation

Query the Spearman rank correlation between a gene's expression level and maximum lifespan across all LACA species in which the queried gene has a confidently mapped ortholog and detectable expression; the exact species set is reported with each result.

Accepts any standard HGNC gene symbol

Popular: TP53 SIRT1 FOXO3 TERT MTOR KLOTHO IGF1R SOD2 LMNA BECN1 PARP1 WRN

Analysis Result

BECN1
Spearman ฯ
+0.2635
rank correlation coefficient
P-value
0.0154
two-tailed significance
Species
84
data points
Significance
P < 0.05
significant
PGLS ฮฒ
-0.065
phylogenetic generalized least squares
PGLS P-value
0.7618
TimeTree5 phylogeny + logโ‚โ‚€ body mass covariate
Pagel's ฮป
0.90
estimated phylogenetic signal
PGLS FDR
1.000
genome-wide corrected
The PGLS statistics above control for phylogenetic relatedness (TimeTree5 time-calibrated phylogeny, Pagel's ฮป estimated by maximum likelihood) and adult body mass. All correlations in LACA are descriptive, species-level associations intended for hypothesis generation; they are not evidence of convergent evolution, natural selection, or causation.
Interpretation: The expression of BECN1 shows a weak positive correlation with maximum lifespan (ฯ = +0.2635). This association is statistically significant (P = 0.0154). Species with higher expression of this gene tend to have longer lifespans. Based on cross-species comparison of 84 species.

Expression vs. Maximum Lifespan

Rankโ€“Rank Plot (Spearman Basis)

Detailed Data (84 species)

# Species Common Name Expression Expr. Rank Max Lifespan (yr) Lifespan Rank
1 Acanthopagrus latus Yellowfin seabream 0.0475 14 15.0 38
2 Amphiprion ocellaris Ocellaris clownfish 0.0818 33 12.0 29.5
3 Amphiprion percula Orange clownfish 0.0518 20 30.0 64
4 Anabas testudineus Climbing perch 0.0295 5 8.0 16.5
5 Astyanax mexicanus Mexican tetra 0.0105 1 5.0 10.5
6 Betta splendens Siamese fighting fish 0.0556 21 5.0 10.5
7 Carassius auratus Goldfish 0.2810 76 41.0 80
8 Channa argus Northern snakehead 0.0868 35 10.0 22
9 Chelmon rostratus Copperband butterflyfish 0.0883 36 10.0 22
10 Chiloscyllium plagiosum Whitespotted bamboo shark 0.0684 26 25.0 59.5
11 Ctenopharyngodon idella Grass carp 0.9397 84 21.0 55
12 Cyprinus carpio Common carp 0.7977 83 38.0 74
13 Echeneis naucrates Live sharksucker 0.0369 8 5.0 10.5
14 Epinephelus fuscoguttatus Brown-marbled grouper 0.0188 2 40.0 78
15 Epinephelus lanceolatus Giant grouper 0.0252 4 37.0 71
16 Erpetoichthys calabaricus Reedfish 0.0504 19 18.0 44.5
17 Esox lucius Northern pike 0.0451 12 30.0 64
18 Gambusia affinis Western mosquitofish 0.0784 31 3.0 1
19 Lates calcarifer Barramundi 0.0558 22 20.0 53.5
20 Mastacembelus armatus Zig-zag eel 0.0394 9 15.0 38
21 Mchenga conophoros Mchenga conophoros 0.0782 30 5.0 10.5
22 Megalobrama amblycephala Blunt snout bream 0.5368 82 15.0 38
23 Melanotaenia boesemani Boeseman's rainbowfish 0.0301 6 8.0 16.5
24 Micropterus salmoides Largemouth bass 0.0458 13 16.0 41
25 Monopterus albus Asian swamp eel 0.0403 11 10.0 22
26 Oncorhynchus mykiss Rainbow trout 0.0396 10 11.0 25.5
27 Plectropomus leopardus Leopard coral trout 0.0740 29 18.0 44.5
28 Poecilia reticulata Guppy 0.0498 17.5 5.0 10.5
29 Polypterus senegalus Senegal bichir 0.0495 16 34.0 68
30 Salarias fasciatus Jewelled blenny 0.0498 17.5 4.0 4.5
31 Scophthalmus maximus Turbot 0.0484 15 25.0 59.5
32 Siniperca chuatsi Chinese perch 0.0221 3 9.0 18.5
33 Synchiropus splendidus Mandarinfish 0.0675 25 5.0 10.5
34 Tetraodon nigroviridis Green spotted puffer 0.0639 24 10.0 22
35 Xiphophorus hellerii Green swordtail 0.0595 23 5.0 10.5
36 Xiphophorus maculatus Southern platyfish 0.0889 37 5.0 10.5
37 Ailuropoda melanoleuca Giant panda 0.0320 7 38.0 74
38 Canis latrans Coyote 0.0956 41 18.0 44.5
39 Felis catus Domestic cat 0.3171 80 38.0 74
40 Mustela putorius furo Domestic ferret 0.1045 42 14.0 34.5
41 Neovison vison American mink 0.1213 46 10.0 22
42 Paguma larvata Masked palm civet 0.0953 40 20.0 50
43 Panthera tigris altaica Siberian tiger 0.1279 48 26.0 61
44 Gallus gallus Red junglefowl 0.1451 57 30.0 64
45 Meleagris gallopavo Wild turkey 0.2131 72 12.0 29.5
46 Taeniopygia guttata Zebra finch 0.1880 66 14.0 34.5
47 Anolis carolinensis Green anole 0.0738 28 7.2 15
48 Aotus nancymaae Nancy ma's night monkey 0.1927 69 20.0 50
49 Callithrix jacchus Common marmoset 0.1617 63 16.5 42
50 Chlorocebus sabaeus Green monkey 0.1076 44 30.1 66
51 Gorilla gorilla Western gorilla 0.1363 54 60.3 82
52 Homo sapiens Human 0.1885 67 122.6 84
53 Macaca fascicularis Crab-eating macaque 0.1500 60 38.4 76
54 Macaca mulatta Rhesus macaque 0.1227 47 40.0 78
55 Macaca nemestrina Pig-tailed macaque 0.1330 52 37.0 70
56 Microcebus murinus Gray mouse lemur 0.3124 79 18.2 47
57 Otolemur garnettii Small-eared galago 0.2064 71 18.0 44.5
58 Pan paniscus Bonobo 0.1458 58 60.0 81
59 Pan troglodytes Common chimpanzee 0.1281 49 68.1 83
60 Papio anubis Olive baboon 0.1329 51 37.5 72
61 Papio hamadryas Hamadryas baboon 0.1052 43 35.6 69
62 Saimiri sciureus Common squirrel monkey 0.1749 64 31.0 67
63 Atelerix albiventris Four-toed hedgehog 0.3046 78 11.0 25.5
64 Manis javanica Sunda pangolin 0.1394 56 13.0 33
65 Oryctolagus cuniculus European rabbit 0.0832 34 12.0 29.5
66 Tupaia belangeri Northern tree shrew 0.0937 39 12.0 29.5
67 Bos taurus Cattle 0.3244 81 22.0 56.5
68 Equus asinus Donkey 0.1175 45 40.0 78
69 Ovis aries Domestic sheep 0.0690 27 20.0 53.5
70 Sus scrofa Pig 0.2295 73 27.0 62
71 Vicugna pacos Alpaca 0.2716 74 23.0 58
72 Branchiostoma floridae Florida lancelet 0.0814 32 4.0 4.5
73 Cavia porcellus Guinea pig 0.2738 75 12.0 29.5
74 Chinchilla lanigera Long-tailed chinchilla 0.1339 53 20.0 50
75 Mesocricetus auratus Golden hamster 0.0903 38 4.0 4.5
76 Mus musculus House mouse 0.2055 70 4.0 4.5
77 Rattus norvegicus Norway rat 0.2865 77 3.8 2
78 Spalax galili Galilee blind mole rat 0.1806 65 20.0 50
79 Urocitellus parryii Arctic ground squirrel 0.1916 68 9.0 18.5
80 Cynopterus sphinx Greater short-nosed fruit bat 0.1381 55 12.0 29.5
81 Myotis ricketti Rickett's big-footed bat 0.1575 61 20.0 50
82 Rhinolophus affinis Intermediate horseshoe bat 0.1284 50 15.0 38
83 Rhinolophus sinicus Chinese rufous horseshoe bat 0.1475 59 15.0 38
84 Rousettus leschenaultii Leschenault's rousette 0.1598 62 22.0 56.5