⚙ How is this computed? Methods: Cross-Species Comparison

Gene Longevity Correlation

Query the Spearman rank correlation between a gene's expression level and maximum lifespan across all LACA species in which the queried gene has a confidently mapped ortholog and detectable expression; the exact species set is reported with each result.

Accepts any standard HGNC gene symbol

Popular: TP53 SIRT1 FOXO3 TERT MTOR KLOTHO IGF1R SOD2 LMNA BECN1 PARP1 WRN

Analysis Result

PARP1
Spearman ฯ
+0.2142
rank correlation coefficient
P-value
0.0315
two-tailed significance
Species
101
data points
Significance
P < 0.05
significant
PGLS ฮฒ
+0.195
phylogenetic generalized least squares
PGLS P-value
0.3985
TimeTree5 phylogeny + logโ‚โ‚€ body mass covariate
Pagel's ฮป
0.90
estimated phylogenetic signal
PGLS FDR
1.000
genome-wide corrected
The PGLS statistics above control for phylogenetic relatedness (TimeTree5 time-calibrated phylogeny, Pagel's ฮป estimated by maximum likelihood) and adult body mass. All correlations in LACA are descriptive, species-level associations intended for hypothesis generation; they are not evidence of convergent evolution, natural selection, or causation.
Interpretation: The expression of PARP1 shows a weak positive correlation with maximum lifespan (ฯ = +0.2142). This association is statistically significant (P = 0.0315). Species with higher expression of this gene tend to have longer lifespans. Based on cross-species comparison of 101 species.

Expression vs. Maximum Lifespan

Rankโ€“Rank Plot (Spearman Basis)

Detailed Data (101 species)

# Species Common Name Expression Expr. Rank Max Lifespan (yr) Lifespan Rank
1 Acanthopagrus latus Yellowfin seabream 0.0810 18.5 15.0 42.5
2 Amphiprion ocellaris Ocellaris clownfish 0.1505 41 12.0 35
3 Amphiprion percula Orange clownfish 0.1690 47 30.0 76
4 Anabas testudineus Climbing perch 0.0960 24 8.0 19.5
5 Astyanax mexicanus Mexican tetra 0.0735 14 5.0 11
6 Atractosteus spatula Alligator gar 0.4369 95 50.0 96
7 Betta splendens Siamese fighting fish 0.1419 39 5.0 11
8 Carassius auratus Goldfish 0.1547 42 41.0 95
9 Channa argus Northern snakehead 0.1053 29 10.0 27.5
10 Chelmon rostratus Copperband butterflyfish 0.1283 35 10.0 27.5
11 Chiloscyllium plagiosum Whitespotted bamboo shark 0.1594 44 25.0 69.5
12 Ctenopharyngodon idella Grass carp 0.0449 5 21.0 63
13 Cyprinus carpio Common carp 0.0238 1 38.0 88
14 Danio rerio Zebrafish 0.0411 4 5.5 16
15 Echeneis naucrates Live sharksucker 0.1588 43 5.0 11
16 Epinephelus fuscoguttatus Brown-marbled grouper 0.0557 9 40.0 92.5
17 Epinephelus lanceolatus Giant grouper 0.0621 11 37.0 84.5
18 Erpetoichthys calabaricus Reedfish 0.3530 86 18.0 49.5
19 Esox lucius Northern pike 0.0724 13 30.0 76
20 Gambusia affinis Western mosquitofish 0.0887 22 3.0 2
21 Lates calcarifer Barramundi 0.0839 21 20.0 59.5
22 Mastacembelus armatus Zig-zag eel 0.0951 23 15.0 42.5
23 Mchenga conophoros Mchenga conophoros 0.1197 33 5.0 11
24 Megalobrama amblycephala Blunt snout bream 0.0359 2 15.0 42.5
25 Melanotaenia boesemani Boeseman's rainbowfish 0.1305 36 8.0 19.5
26 Micropterus salmoides Largemouth bass 0.0454 6 16.0 46
27 Misgurnus anguillicaudatus Pond loach 0.1757 49 10.0 27.5
28 Monopterus albus Asian swamp eel 0.0824 20 10.0 27.5
29 Oncorhynchus mykiss Rainbow trout 0.0513 8 11.0 31.5
30 Petromyzon marinus Sea lamprey 0.4576 96 9.0 23
31 Plectropomus leopardus Leopard coral trout 0.1339 38 18.0 49.5
32 Poecilia reticulata Guppy 0.0670 12 5.0 11
33 Polypterus senegalus Senegal bichir 0.6851 100 34.0 81
34 Protopterus annectens West african lungfish 0.4929 97 25.0 69.5
35 Salarias fasciatus Jewelled blenny 0.1045 28 4.0 5
36 Scleropages formosus Asian arowana 0.0988 25 20.0 59.5
37 Scophthalmus maximus Turbot 0.1038 27 25.0 69.5
38 Siniperca chuatsi Chinese perch 0.0770 17 9.0 23
39 Synchiropus splendidus Mandarinfish 0.1082 30 5.0 11
40 Tachysurus fulvidraco Yellow catfish 0.0739 15 8.0 19.5
41 Tetraodon nigroviridis Green spotted puffer 0.0810 18.5 10.0 27.5
42 Xiphophorus hellerii Green swordtail 0.0756 16 5.0 11
43 Xiphophorus maculatus Southern platyfish 0.1011 26 5.0 11
44 Ailuropoda melanoleuca Giant panda 0.0407 3 38.0 88
45 Canis latrans Coyote 0.3093 80 18.0 49.5
46 Canis lupus familiaris Domestic dog 0.2917 75 24.0 67
47 Felis catus Domestic cat 0.4358 94 38.0 88
48 Mustela putorius furo Domestic ferret 0.3044 79 14.0 38.5
49 Neovison vison American mink 0.1992 52 10.0 27.5
50 Panthera tigris altaica Siberian tiger 0.1600 45 26.0 72
51 Ambystoma mexicanum Axolotl 0.2725 68 20.0 59.5
52 Pleurodeles waltl Iberian ribbed newt 0.1328 37 20.0 59.5
53 Xenopus laevis African clawed frog 0.1638 46 30.0 76
54 Gallus gallus Red junglefowl 0.3926 92 30.0 76
55 Taeniopygia guttata Zebra finch 0.3443 85 14.0 38.5
56 Anolis carolinensis Green anole 0.3592 88 7.2 17
57 Chrysemys picta Painted turtle 0.3879 90 61.0 99
58 Mauremys mutica Asian yellow pond turtle 0.3273 81 30.0 76
59 Mauremys reevesii Chinese pond turtle 0.2711 67 25.0 69.5
60 Pogona vitticeps Central bearded dragon 0.5964 98 15.0 42.5
61 Trachemys scripta elegans Red-eared slider 0.3566 87 40.0 92.5
62 Aotus nancymaae Nancy ma's night monkey 0.2373 56 20.0 54.5
63 Callithrix jacchus Common marmoset 0.2826 73 16.5 47
64 Chlorocebus sabaeus Green monkey 0.2551 62 30.1 79
65 Gorilla gorilla Western gorilla 0.2609 65 60.3 98
66 Homo sapiens Human 0.2943 76 122.6 101
67 Macaca fascicularis Crab-eating macaque 0.3025 78 38.4 90
68 Macaca mulatta Rhesus macaque 0.2631 66 40.0 92.5
69 Macaca nemestrina Pig-tailed macaque 0.1918 51 37.0 83
70 Microcebus murinus Gray mouse lemur 0.1732 48 18.2 52
71 Otolemur garnettii Small-eared galago 0.4232 93 18.0 49.5
72 Pan paniscus Bonobo 0.2606 64 60.0 97
73 Pan troglodytes Common chimpanzee 0.2352 55 68.1 100
74 Papio anubis Olive baboon 0.2374 57 37.5 86
75 Papio hamadryas Hamadryas baboon 0.3385 83 35.6 82
76 Saimiri sciureus Common squirrel monkey 0.2781 70 31.0 80
77 Atelerix albiventris Four-toed hedgehog 0.1436 40 11.0 31.5
78 Dasypus novemcinctus Nine-banded armadillo 0.1147 32 20.0 59.5
79 Monodelphis domestica Gray short-tailed opossum 0.6466 99 4.0 5
80 Oryctolagus cuniculus European rabbit 0.2395 58 12.0 35
81 Tupaia belangeri Northern tree shrew 0.2513 60 12.0 35
82 Bos taurus Cattle 0.0476 7 22.0 64.5
83 Equus asinus Donkey 0.2771 69 40.0 92.5
84 Ovis aries Domestic sheep 0.1100 31 20.0 59.5
85 Sus scrofa Pig 0.2552 63 27.0 73
86 Vicugna pacos Alpaca 0.2225 54 23.0 66
87 Ciona savignyi Pacific transparent sea squirt 0.9668 101 1.0 1
88 Cavia porcellus Guinea pig 0.2110 53 12.0 35
89 Chinchilla lanigera Long-tailed chinchilla 0.2861 74 20.0 54.5
90 Heterocephalus glaber Naked mole rat 0.2427 59 37.0 84.5
91 Mus musculus House mouse 0.1259 34 4.0 5
92 Peromyscus maniculatus Baird's deer mouse 0.2524 61 8.0 19.5
93 Peromyscus polionotus Oldfield mouse 0.2802 71 5.0 11
94 Rattus norvegicus Norway rat 0.1868 50 3.8 3
95 Spalax galili Galilee blind mole rat 0.0581 10 20.0 54.5
96 Urocitellus parryii Arctic ground squirrel 0.2819 72 9.0 23
97 Cynopterus sphinx Greater short-nosed fruit bat 0.3308 82 12.0 35
98 Myotis ricketti Rickett's big-footed bat 0.2947 77 20.0 54.5
99 Rhinolophus affinis Intermediate horseshoe bat 0.3626 89 15.0 42.5
100 Rhinolophus sinicus Chinese rufous horseshoe bat 0.3441 84 15.0 42.5
101 Rousettus leschenaultii Leschenault's rousette 0.3917 91 22.0 64.5